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Store-operated Ca2+ entry in rhabdomyosarcoma cells
Biochemical and Biophysical Research Communications, 2016Rhabdomyosarcoma (RMS), the most common pediatric soft tissue sarcoma, has an intrinsic or early-acquisition of resistance to chemo- and radiation therapy. Molecular determinants pivotal for RMS migration, metastatic invasion, cell proliferation, and survival are incompletely identified.
Evi, Schmid +6 more
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Tissue Specificity: Store-Operated Ca2+ Entry in Cardiac Myocytes
2017Calcium (Ca2+) is a key regulator of cardiomyocyte contraction. The Ca2+ channels, pumps, and exchangers responsible for the cyclical cytosolic Ca2+ signals that underlie contraction are well known. In addition to those Ca2+ signaling components responsible for contraction, it has been proposed that cardiomyocytes express channels that promote the ...
Martin D, Bootman, Katja, Rietdorf
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Store-Operated Ca2+ Entry in Drosophila Primary Neuronal Cultures
2018Intracellular calcium signals in neurons frequently derive from the stimulation of G protein-coupled receptors (GPCR) by neurotransmitters, neuropeptides, and neurohormones. GPCR stimulation in neurons leads to generation of inositol 1,4,5-trisphosphate (IP3), which in turn activates endoplasmic reticulum (ER)-localized IP3 receptors. The IP3 receptor (
Sumita, Chakraborty, Gaiti, Hasan
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Ca2+ ionophores trigger membrane remodeling without a need for store-operated Ca2+ entry
Biochemical and Biophysical Research Communications, 2005Calcium (Ca2+) ionophores are the most effective agents able to elicit rapid membrane remodeling in vitro. This process exposes aminophospholipids at the surface of platelets and blood cells, thus providing a catalytic surface for coagulation. To explore the underlying mechanism, we examined if cytosolic Ca2+ ([Ca2+]i) increase through store-operated ...
Marie, Galitzine +5 more
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Toward the roles of store-operated Ca2+ entry in skeletal muscle
Pflügers Archiv - European Journal of Physiology, 2010Store-operated Ca(2+) entry (SOCE) has been found to be a rapidly activated robust mechanism in skeletal muscle fibres. It is conducted across the junctional membranes by stromal interacting molecule 1 (STIM1) and Orai1, which are housed in the sarcoplasmic reticulum (SR) and tubular (t-) system, respectively.
Launikonis, Bradley S. +2 more
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Historical Overview of Store-Operated Ca2+ Entry
2016Calcium influx is an essential mechanism for the activation of cellular functions both in excitable and non-excitable cells. In non-excitable cells, activation of phospholipase C by occupation of G protein-coupled receptors leads to the generation of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), which, in turn, initiate two Ca(2+) entry ...
Letizia, Albarran +3 more
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Tunicamycin desensitizes store-operated Ca2+ entry to ATP and mitochondrial potential
Biochemical and Biophysical Research Communications, 2009Tunicamycin effect on thapsigargin-induced store-operated calcium entry was investigated. Ca2+ influx was stimulated by 50% upon exposure of Jurkat cells to tunicamycin. Moreover, tunicamycin efficiently prevented the inhibition of store-operated calcium entry caused by dissipation of mitochondrial membrane potential.
Aneta, Czyź +4 more
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Analysis of Store-Operated Ca2+ Entry in Primary T Cells
Calcium ions (Ca2+) are key second messengers for signal transduction in virtually all cells. In T cells, Ca2+ signals are generated upon T cell receptor (TCR) stimulation in a two-step integrated process known as Store-Operated Ca2+ Entry (SOCE), which involves the depletion of endoplasmic reticulum (ER) Ca2+ stores, followed by the influx of ...Sara T, Granados +3 more
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