Results 211 to 220 of about 10,284 (252)
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Proteins Interacting with STIM1 and Store-Operated Ca2+ Entry
2021The endoplasmic reticulum (ER) Ca2+ sensor stromal interaction molecule 1 (STIM1) interacts with ORAI Ca2+ channels at the plasma membrane to regulate immune and muscle cell function. The conformational changes underlying STIM1 activation, translocation, and ORAI1 trapping and gating, are stringently regulated by post-translational modifications and ...
Wang, Wen-An, Demaurex, Nicolas
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Toxicology and Applied Pharmacology, 2005
Rat neutrophils express the mRNA encoding for transient receptor potential (TRP) V1. However, capsaicin-stimulated [Ca2+]i elevation occurred only at high concentrations (> or = 100 microM). This response was substantially decreased in a Ca2+-free medium.
Jih-Pyang, Wang +5 more
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Rat neutrophils express the mRNA encoding for transient receptor potential (TRP) V1. However, capsaicin-stimulated [Ca2+]i elevation occurred only at high concentrations (> or = 100 microM). This response was substantially decreased in a Ca2+-free medium.
Jih-Pyang, Wang +5 more
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Lifting the fog in store-operated Ca2+ entry
Trends in Immunology, 2005Immunoreceptor signalling leads to Ca2+ release from intracellular stores, which is followed by the entry of external Ca2+ into the cell through mysterious store-operated Ca2+ (SOC) channels. Recent studies have identified stromal interaction molecules (STIMs) as having an essential role in SOC influx.
Petr, Dráber, Lubica, Dráberová
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Modeling the impact of store-operated Ca2+ entry on intracellular Ca2+ oscillations
Mathematical Biosciences, 2006Calcium (Ca2+) oscillations play fundamental roles in various cell signaling processes and have been the subject of numerous modeling studies. Here we have implemented a general mathematical model to simulate the impact of store-operated Ca2+ entry on intracellular Ca2+ oscillations.
Jacob M, Kowalewski +3 more
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2012
Store-operated Ca(2+) entry (SOCE) is an ubiquitous and major mechanism for Ca(2+) influx in mammalian cells with important physiological relevance. Since the discovery of SOCE in 1986 both, the mechanism that communicates the amount of Ca(2+) accumulated in the intracellular Ca(2+) stores to the plasma membrane channels and the nature of the ...
Alejandro, Berna-Erro +2 more
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Store-operated Ca(2+) entry (SOCE) is an ubiquitous and major mechanism for Ca(2+) influx in mammalian cells with important physiological relevance. Since the discovery of SOCE in 1986 both, the mechanism that communicates the amount of Ca(2+) accumulated in the intracellular Ca(2+) stores to the plasma membrane channels and the nature of the ...
Alejandro, Berna-Erro +2 more
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Store-Operated Ca2+ Entry in Muscle Physiology
Current Chemical Biology, 2007Store-operated Ca 2+ entry (SOCE) represents a unique Ca 2+ entry mechanism, where Ca 2+ channels located on the plasma membrane sense the Ca 2+ filling status of intracellular Ca 2+ stores and gate the entry of Ca 2+ from the extracel- lular reservoir to replenish intracellular Ca 2+ storage.
Marco Brotto, Noah Weisleder, Jianjie Ma
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Store-operated Ca2+ entry: a STIMulating stOrai
Trends in Biochemical Sciences, 2006Store-operated Ca2+ entry (SOCE) mediates much of the Ca2+ entry evoked by receptors that stimulate phospholipase C. However, for 20 years, the plasma membrane Ca2+ channel and the signal linking its activation to loss of Ca2+ from the endoplasmic reticulum (ER) have eluded detection. But the search might now be over.
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IP3R, store-operated Ca2+ entry and neuronal Ca2+ homoeostasis in Drosophila
Biochemical Society Transactions, 2012The IP3R (inositol 1,4,5-trisphosphate receptor) releases Ca2+ from the ER (endoplasmic reticulum) store upon binding to its ligand InsP3, which is thought to be generated by activation of certain membrane-bound G-protein-coupled receptors in Drosophila.
Sumita, Chakraborty, Gaiti, Hasan
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Store-operated Ca2+ entry-dependent Ca2+ refilling in the endoplasmic reticulum in astrocytes
Biochemical and Biophysical Research Communications, 2020Astrocytes regulate various brain functions, for which Ca2+ release from the endoplasmic reticulum (ER) often play crucial roles. Because astrocytic ER Ca2+ release is robust and frequent, the ER Ca2+ refilling mechanism should be critical for ongoing Ca2+ signaling in astrocytes.
Yohei Okubo +2 more
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CIF and other mysteries of the store-operated Ca2+-entry pathway
Trends in Biochemical Sciences, 2005The molecular mechanism of the store-operated Ca2+-entry (SOCE) pathway remains one of the most intriguing and long lasting mysteries of Ca2+ signaling. The elusive calcium influx factor (CIF) that is produced upon depletion of Ca2+ stores has attracted growing attention, triggered by new discoveries that filled the gap in the chain of reactions ...
Victoria M, Bolotina, Peter, Csutora
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