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Methods for studying store-operated calcium entry [PDF]
Methods, 2008 Activation of surface membrane receptors coupled to phospholipase C results in the generation of cytoplasmic Ca2+ signals comprised of both intracellular Ca2+ release, and enhanced entry of Ca2+ across the plasma membrane. A primary mechanism for this Ca2+ entry process is attributed to store-operated Ca2+ entry, a process that is activated by ...
Jeremy Smyth, James Putney, Gary Bird
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Molecular modulators of store-operated calcium entry
Biochimica Et Biophysica Acta - Molecular Cell Research, 2016 Three decades ago, store-operated Ca(2+) entry (SOCE) was identified as a unique mechanism for Ca(2+) entry through plasma membrane (PM) Ca(2+)-permeable channels modulated by the intracellular Ca(2+) stores, mainly the endoplasmic reticulum (ER). Extensive analysis of the communication between the ER and the PM leads to the identification of the ...
Tarik Smani, Lopez Jj, Gines M Salido
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Store-Operated Calcium Entry in the Cardiovascular System
2021Calcium (Ca2+) is a critical regulator of cardiovascular function. The Ca2+ channels, pumps, and exchangers contributing to cytosolic Ca2+ signals governing cardiac contraction and vascular tone are well known. In addition to these Ca2+ components, store-operated calcium entry (SOCE) is a ubiquitous mechanism recently recognized underlying ...
Xian, Liu, Zui, Pan
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Seminars in Neuroscience, 1996
Many hormones, growth factors and neurotransmitters stimulate the production of inositol 1,4,5-trisphosphate evoking the release of calcium from intracellular stores. The depletion of these intracellular calcium stores subsequently activates a voltage-independent plasma membrane calcium influx in many cell types.
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Many hormones, growth factors and neurotransmitters stimulate the production of inositol 1,4,5-trisphosphate evoking the release of calcium from intracellular stores. The depletion of these intracellular calcium stores subsequently activates a voltage-independent plasma membrane calcium influx in many cell types.
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Store-Operated Calcium Entry in Mouse Cardiomyocytes
Bulletin of Experimental Biology and Medicine, 2019The fluorescent dye fura-2 AM was employed to record activation of Ca2+ entry in response to a decrease in Ca2+ concentration in the endoplasmic reticulum. Using whole-cell voltage clamp technique, we revealed Ca2+ currents with an amplitude of 0.46±0.13 pA/pF that passed through selective channels with current-voltage characteristics similar to those ...
K O, Gusev +5 more
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The cellular and molecular basis of store-operated calcium entry
Nature Cell Biology, 2002The impact of calcium signalling on so many areas of cell biology reflects the crucial role of calcium signals in the control of diverse cellular functions. Despite the precision with which spatial and temporal details of calcium signals have been resolved, a fundamental aspect of the generation of calcium signals -- the activation of 'store-operated ...
Kartik, Venkatachalam +4 more
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Store-operated calcium entry in thrombosis and thrombo-inflammation
Cell Calcium, 2019Cytosolic free calcium (Ca2+) is a second messenger regulating a wide variety of functions in blood cells, including adhesion, activation, proliferation and migration. Store-operated Ca2+ entry (SOCE), triggered by depletion of Ca2+ from the endoplasmic reticulum, provides a main mechanism of regulated Ca2+ influx in blood cells.
Elmina, Mammadova-Bach +4 more
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Small‐Molecule Inhibitors of Store‐Operated Calcium Entry
ChemMedChem, 2009AbstractMolecules that inhibit store‐operated calcium entry (SOCE) are potentially useful immunomodulating agents. The identification of proteins involved in this pathway may further enable the identification of selective inhibitors. Herein we document some examples of the small‐molecule inhibitors of SOCE that have been reported to date.
Zachary K, Sweeney +3 more
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Spatiotemporal regulation of store-operated calcium entry in cancer metastasis
Biochemical Society Transactions, 2021The store-operated calcium (Ca2+) entry (SOCE) is the Ca2+ entry mechanism used by cells to replenish depleted Ca2+ store. The dysregulation of SOCE has been reported in metastatic cancer. It is believed that SOCE promotes migration and invasion by remodeling the actin cytoskeleton and cell adhesion dynamics.
Fujian Lu +4 more
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Store-Operated Calcium Entry: A Tough Nut to CRAC
Science's STKE, 2004Store-operated or capacitative Ca 2+ entry is a prominent feature of many electrically nonexcitable cell types. It is due to Ca 2+ ion permeation pathways in the plasma membrane that are activated after receptor-mediated Ca 2+ release from intracellular stores. Despite
Reinhold, Penner, Andrea, Fleig
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