ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Effect of Strategic Planning of Human Resources in Management Performance [PDF]
, 2022 Ahmad Abujraiban, Gabriel J. Assaf
openalex +1 more source
The Challenges of Strategic Human Resources Management in Southeast Asian Universities [PDF]
, 2018 Nowadays the Higher Education Institutions face major challenges in its development. Demanding from different actors and the orientation of the research, more oriented to innovation and value creation, request news capacities to answer to that. Southeast
Jorge, F., Saraiva, M., Silva, P.
core
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Design the Strategies of Human Resources by Means of SWOT Method [PDF]
مطالعات مدیریت بهبود و تحول, 2014 Human resources are the basic column in organization and human resources management is considered as the strategic activity for maintaining and reinforcement the competitive advantage.
Mohsen Moradi, Mohammad Rasoul Heshmati
doaj
Quality Improvement Model of Nursing Education in Muhammadiyah Universities Toward Competitive Advantage [PDF]
, 2017 Introduction: Most of (90,6%) nursing education quality in East Java was still low (BAN-PT, 2012). It was because the quality improvement process in nursing education generally was conducted partially (random performance improvement).
Hidayat, A. A. (Abdul) +2 more
core +2 more sources
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Strategic Management of Human Resources
EIRP Proceedings, 2014 In the context of Romania’s integration into European structures, the modernization process of educational system constitutes a natural necessity. This scientific approach has proposed a comprehensive approach of the issue of the Community programs ...
Madlena Nen
doaj
Sustainable bioplastics manufacturing from renewable sources
FEBS Open Bio, EarlyView.Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto +6 more
wiley +1 more source
Human Resources: Strategic Management Aspects Žmogiškieji ištekliai: strateginio valdymo aspektai
Business, Management and Education, 2011 <p class="MsoNormal" style="margin: 0cm 0cm 10pt;"><span style="line-height: 115%; font-family: "Verdana","sans-serif"; font-size: 9pt;">The following processes pose challenges for the organization: self ...
Eugenijus Chlivickas +2 more
doaj +1 more source