Results 61 to 70 of about 1,369,680 (320)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Integrating Organizational Culture in Strategic Human Resource Management of the Educational Institutions [PDF]

Ovidius University Annals: Economic Sciences Series, 2019
Human resources are readily recognized as the most important resource of the resources needed for an organization in order to produce goods and services. Human resources are key to rapid socio-economic development and efficient service delivery.
Monica Logofătu
doaj  

Human Resources: Strategic Management Aspects Žmogiškieji ištekliai: strateginio valdymo aspektai

Business, Management and Education, 2011
<p class="MsoNormal" style="margin: 0cm 0cm 10pt;"><span style="line-height: 115%; font-family: &quot;Verdana&quot;,&quot;sans-serif&quot;; font-size: 9pt;">The following processes pose challenges for the organization: self ...
Eugenijus Chlivickas, Palmira Papšienė, Arnas Papšys   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Global versus local managing human resources in the multinational company [PDF]

, 1996
This paper considers the extent to which multinational enterprises adopt a global or local approach in their management of human resources. Nine organisations, drawn from a range of nationalities and sectors operating in Ireland, were examined.
Monks, Kathy
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Modeling Strategic-Knowledge-Resource Management Based on Individual Competencies in SMEs

Contemporary Economics, 2011
A number of publications have dealt with the correlation between knowledge-management capability and competitiveness. In the article describing human resources as strategic-knowledge resources, which is motivated by: the concept of effective management ...
Justyna Patalas-Maliszewska, Martin Hochmeister   +1 more
doaj   +1 more source

An examination of e-HRM as a means to increase the value of the HR function [PDF]

, 2011
This article examines the potential use of e-human resource management (e-HRM) as ameans to increase the value of the human resources (HR) function, within theframework of the resource-based view.
Parry, Emma
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Multiple Relationship Strategic Human Resources Management and Intellectual Capital in Public University of Isfahan [PDF]

مطالعات مدیریت راهبردی, 2011
In the present study the multiple relationship between strategic human resource management practices and intellectual capital be reviewed. Strategic human resource management practices, tools for improving and enhancing their knowledge and experiences of
Susan Bahrami, Saeed Rajaeepour, Mohammad Hossein Yarmohammadian, Iraj Kazemi   +3 more
doaj