Results 101 to 110 of about 87,981 (309)

Transfersomes with core and surface‐loaded NF‐κB p65 siRNA for enhanced transdermal transfection and effective treatment of psoriasis

BMEMat, EarlyView.
TCPL, a transfersome with Tween 80 and PEI, enables efficient transdermal siNF‐κB delivery, resolving PEI's toxicity issue. It promotes lysosomal escape and effective transfection, silences NF‐κB, modulates immunity, and inhibits angiogenesis, alleviating psoriasis. With good biocompatibility, TCPL holds strong clinical translation potential. Schematic
Hui Xing, Yuhui Yang, Ziyi Zhao, Kai Lv, Yiran Shao, Zhi Zhang, Dong Ma   +6 more
wiley   +1 more source

Cellular Architecture of the Stratum Corneum

Journal of Investigative Dermatology, 1971
The formation of columns of cells in the horny layer has been confirmed using a new fluorescent staining technique. The inception of this orderly pattern was evident within 2-3 subcorneal cell layers. Germinative cells can be identified on the basis of their comparatively low dye uptake. The conspicuous staining of the cell membranes in the horny layer
openaire   +2 more sources

Characterization of the influence of some cyclodextrins on the stratum corneum from the hairless mouse

, 1997
Differential scanning calorimetry (DSC), Fourier-transform infrared FTIR) spectroscopy and transmission electron microscopy (TEM) have been used to determine the influence of β-cyclodextrin (β-CyD), hydroxypropyl-β-CyD (HP-β-CyD) and γ-CyD on the ...
M Vitória L B Bentley, Wilson, Susan, John H Collett, Bentley, M. Vitória L B, Susan Wilson, Vianna, Renata F., Collett, John H., Renata F Vianna   +7 more
core   +1 more source

A narrow bandgap Schottky heterojunction Fe2N/CeO2 microneedle triggering sonodynamic reactive oxygen species storm for drug‐resistance‐free skin fungal infection

BMEMat, EarlyView.
Inorganic sonosensitizers suffer from inefficient electron‐hole separation, rapid recombination, and wide bandgaps in anti‐fungal applications. We propose MN@Fe2N/CeO2 to directly eliminate fungi without drug resistance. Combining semiconductor CeO2's advantages with Fe2N's high work function and activity enables efficient Schottky heterojunctions ...
Li Wang, Jiayi Yang, Ning Tang, Youbin Zheng, Yichao Hou, Chutong Liu, Lihao Guo, Yingying Liao, Gandong Zhou, Weiwei Wu, Xin Du, Shuxiang Xu, Jie Yin, Miaomiao Yuan   +13 more
wiley   +1 more source

Collection of stratum corneum samples and sweat samples from healthy controls and atopic dermatitis cases.

, 2015
HC: healthy control.AD: atopic dermatitis.Collection of stratum corneum samples and sweat samples from healthy controls and atopic dermatitis cases.
Jun-Ichi Sakabe (731110), Taisuke Ito (731113), Yoshiki Tokura (439327), Koji Kamiya (731109), Masahiro Aoshima (714535), Tsuyoshi Yatagai (731112), Hayato Yamaguchi (731111), Takahiro Suzuki (88656)   +7 more
core   +1 more source

Topical bioavailability of glucocorticosteroids : dermatopharmacokinetic and dermatopharmacodynamic of topically applied triamcinolone acetonide in humans [PDF]

, 2006
The aim of the present thesis was the in vivo investigation of the topical bioavailability of a model glucocorticosteroid, triamcinolone acetonide (TACA), using tape stripping. The layer by layer removal of the stratum corneum by tape stripping enables
Pellanda, Carolina
core   +1 more source

Exosome‐mimetic vesicle‐encapsulated multi‐responsive antibacterial hydrogel core‐shell microneedle patch promotes scarless healing of infected wounds

BMEMat, EarlyView.
The core‐shell microneedle patch VP@FNV‐CuO2‐MN was fabricated by encapsulating n‐CuO2 in a moderately crosslinked PVA/CMCS/Borax4 hydrogel shell and VP‐loaded fibroblast membrane nanovesicles (VP@FNV) in a highly crosslinked PVA/CMCS/Borax6 hydrogel core. Upon application to an infected wound, the acidic microenvironment triggers Fenton‐like reactions
Ziwei Jiang, Huihui Zhang, Lianglong Chen, Zhangfeifan Yang, Sai Cao, Yufang He, Xiaoyang Liu, Siew Yee Wong, Xu Li, Hai Zhou, Ziyan Li, Zijun Zheng, Lei Yang   +12 more
wiley   +1 more source

6-Hydroxy-4-sphingenine in human epidermal ceramides.

Journal of Lipid Research, 1994
The solvent-extractable lipids of human epidermal stratum corneum consist predominantly of ceramides. In addition two non-extractable ceramides are chemically bound to the stratum corneum protein. One of the bound ceramides, constituting 50% of the bound
K J Robson, M E Stewart, S Michelsen, N D Lazo, D T Downing   +4 more
doaj   +1 more source

Quantification of Palmar and Digital Epidermal Thickness and Sweat Duct Density

Clinical Anatomy, EarlyView.
ABSTRACT Palmar digital skin, with its high density of epidermal sweat glands and unique stratum corneum, derives its autonomic innervation from peripheral nerves. Understanding the changes to these structures could serve as objective proxy markers following peripheral nerve injury and interventions to promote regeneration.
Elizabeth Jones, Hanaa N. Mughal, Roxana Moscalu, Malachy Columb, Christopher Duff, Mark Dickinson, Adam J. Reid, Ralph N. A. Murphy   +7 more
wiley   +1 more source

The Needle‐Free Frontier: Redefining the Limits of Transdermal Insulin Delivery

Exploration, EarlyView.
Wei and colleagues reported a pH‐responsive, charge‐switchable polyzwitterionic polymer carrier that achieves non‐invasive transdermal insulin delivery without external energy input. The approach leverages adaptive compatibility with the cutaneous microenvironment to shuttle functional macromolecules across intact skin and achieve definitive systemic ...
Junge Chen, Yuxuan Liu, Bozhang Xia, Julien Milon Essola, Xing‐Jie Liang   +4 more
wiley   +1 more source