Results 81 to 90 of about 87,981 (309)

Lipid Metabolic Dysregulation Driven by OSMR Mutations Underlies Amyloidogenesis in Primary Localized Cutaneous Amyloidosis

Advanced Science, EarlyView.
OSMR mutations disrupt STAT5 signaling and AKR1B10‐mediated lipid metabolism, leading to lipid accumulation and protein aggregation in keratinocytes. This metabolic reprogramming drives amyloid deposition in primary localized cutaneous amyloidosis, revealing a mechanistic link between lipid dysregulation and amyloidogenesis.
Huiting Liu, Wen Zheng, Chao Yang, Tao Yang, Qiuyu Chen, Ping Lu, Huan Yang, Jun Liu, Bin Yang   +8 more
wiley   +1 more source

Stratum corneum tryptic enzyme in normal epidermis : a missing link in the desquamation process?

, 2000
Stratum corneum chymotryptic enzyme may be important in desquamation. It has also been suggested that other proteases, especially stratum corneum tryptic enzyme, may be involved.
Brattsand, Maria,, Egelrud, Torbjörn,, Ekholm, I Elisabeth,   +2 more
core   +1 more source

Selective substrates and inhibitors for kallikrein-related peptidase 7 (KLK7) shed light on KLK proteolytic activity in the stratum corneum [PDF]

, 2017
Proteases have pivotal roles in the skin's outermost layer, the epidermis. In the stratum corneum, serine proteases from the kallikrein-related peptidase (KLK) family have been implicated in several key homeostatic processes, including desquamation ...
Brattsand, Maria, Brattsand, Maria,, Swedberg, Joakim E., Clements, Judith A., Hovnanian, Alain, Harris, Jonathan M., Furio, Laetitia, de Veer, Simon J., Munro, Christopher A.   +8 more
core   +2 more sources

Fatty acidome and aminoacidome in sebum and stratum corneum in adult healthy subjects and patients with atopic dermatitis

, 2022
Semiquantitative data of metabolites analyzed in human sebum and stratum corneum lipid ...
Emanuela Camera
core   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Efficacy of a Moisturizer for Pruritus Accompanied With Asteatosis in Dialysis Patients: An Open-Label, Randomized, Exploratory Study

Kidney Medicine, 2019
Background: In dialysis patients, skin disorders (dryness and itching) are frequently observed and treated with a moisturizer, in the absence of clear evidence of efficacy.
Yukie Yoshida, Kazumasa Hashimoto, Hidehisa Saeki, Fumiaki Itagaki, Akio Hirama, Atsuko Suzuki, Kayo Iiyama, Yumi Fukunaga, Hiroyuki Enomoto, Eiji Kushima, Momoyo Kishida, Seiki Fujimoto, Shuichi Tsuruoka   +12 more
doaj   +1 more source

Mechanical Properties of the Human Stratum Corneum: Hydration Effects on Graded Delamination of Human Stratum Corneum

, 2006
The stratum corneum ...
James Li
core  

Sustainable Hydrogel‐Forming Microneedle‐Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation

Advanced Science, EarlyView.
Hydrogel‐forming microneedle (HFMN)‐reservoir patches provide a modular route for controlled transdermal delivery of hydrophilic biomacromolecules. The platform integrates skin‐barrier penetration, sustainable biopolymers, scalable green manufacturing, hydration‐driven transport, model‐cargo validation, and translational quality requirements.
Siddharth Mohanty, Mehmet Onur Aydogdu, Sijia Kang, Xinbo Li, Mohan Edirisinghe   +4 more
wiley   +1 more source

The Tape-Stripping Technique as a Method for Drug Quantification in Skin

Journal of Pharmacy & Pharmaceutical Sciences, 2008
Quantification of drugs within the skin is essential for topical and transdermal delivery research. Over the last two decades, horizontal sectioning, consisting of tape stripping throughout the stratum corneum, has become one of the traditional ...
Jose Juan Escobar-Chavez, V. Merino-Sanjuán, M. López-Cervantes, Z. Urban-Morlan, E. Piñón-Segundo, D. Quintanar-Guerrero, A. Ganem-Quintanar   +6 more
doaj   +1 more source

Identification of compounds in red wine that effectively upregulate aquaporin-3 as a potential mechanism of enhancement of skin moisturizing

Biochemistry and Biophysics Reports, 2020
In a previous clinical study, the moisture content in the stratum corneum of healthy Japanese women who consumed a beverage rich in oligomeric proanthocyanidins (OPCs) made from red wine extract was found to be higher than that in the control group. This
Yumi Nakamura, Takatsugu Tsuchiya, Mariko Hara-Chikuma, Masato Yasui, Yuko Fukui   +4 more
doaj   +1 more source