Results 111 to 120 of about 46,670 (310)

Mechanism investigation of ethosomes transdermal permeation

International Journal of Pharmaceutics: X, 2019
Ethosomes are widely used to promote transdermal permeation of both lipophilic and hydrophilic drugs, but the mechanism of interaction between the ethosomes and the skin remains unclear.
Xiao-Qian Niu, Dan-Ping Zhang, Qiong Bian, Xing-Fu Feng, Hao Li, Yue-Feng Rao, Yong-Mei Shen, Fu-Neng Geng, An-Ran Yuan, Xiao-Ying Ying, Jian-Qing Gao   +10 more
doaj   +1 more source

Cellular Architecture of the Stratum Corneum

Journal of Investigative Dermatology, 1971
The formation of columns of cells in the horny layer has been confirmed using a new fluorescent staining technique. The inception of this orderly pattern was evident within 2-3 subcorneal cell layers. Germinative cells can be identified on the basis of their comparatively low dye uptake. The conspicuous staining of the cell membranes in the horny layer
openaire   +2 more sources

Design Considerations for Polymer–Deep Eutectic Solvent Hybrid Systems for Transdermal Drug Delivery

Journal of Applied Polymer Science, EarlyView.
Deep eutectic solvents (DESs) act as tunable, green excipients that modulate polymer structure–property relationships to enhance drug solubility, skin permeation, stability, and controlled release. Through hydrogen‐bond interactions, DES–polymer hybrid systems enable improved transdermal performance, offering a rational, design‐driven platform for ...
Madhavi Kailas Kapale, Madhur Kulkarni, Pranav J. Shah, Furqan A. Maulvi   +3 more
wiley   +1 more source

Imaging the electric field associated with mouse and human skin wounds [PDF]

, 2008
We have developed a noninvasive instrument called the bioelectric field imager (BFI) for mapping the electric field between the epidermis and the stratum corneum near wounds in both mouse and human skin.
Sanger, Richard, Samdeo Ramlatchan, Richard Sanger, Nuccitelli, Richard, Peter J.S. Smith, Ramlatchan, Samdeo, Richard Nuccitelli, Nuccitelli, Pamela, Smith, Peter J.S., Pamela Nuccitelli   +9 more
core   +1 more source

Ceramides metabolism and impaired epidermal barrier in cutaneous diseases and skin aging: focus on the role of the enzyme PNPLA1 in the synthesis of ω-O-acylceramides and its pathophysiological involvement in some forms of congenital ichthyoses☆

Oilseeds and fats, crops and lipids, 2019
The outermost layer of the skin, the stratum corneum, is essential for the protective barrier functions of the skin. It results from the stacking of corneocytes, the dead flattened cells resulting from epidermal terminal differentiation of underlying ...
Jonca Nathalie
doaj   +1 more source

Sheep Horn Development Revealed by Multi‐Tissue and Cross‐Species Transcriptomic Analysis

Animal Research and One Health, EarlyView.
Multi‐tissue and cross‐species transcriptomics with allele‐specific expression show sheep horns are a composite organ integrating epidermal and osteogenic programs. Conserved horn gene modules and cis‐regulatory variation fine‐tune expression networks underlying horn development and size (small scurs vs. large spiral horns).
Hao Li, Yuchen He, Yangshuo Hu, Naominggaowa, Huaiqiang Yang, Zhu Meng, Fei Liu, Shiwen Zhang, Yi Jin, Mingxing Chu, Zhangyuan Pan   +10 more
wiley   +1 more source

Ethnicity and stratum corneum ceramides [PDF]

, 2010
BACKGROUND: The barrier function of the skin is dependent on an optimal composition of the stratum corneum lipids, exemplified by the altered lipid profile in patients with atopic eczema (AE).
J.M. Jungersted, Jungersted, J M, Høgh, J K, G.B.E. Jemec, L.I. Hellgren, Jemec, Gregor, Jemec, G., Agner, T, Jungersted, J.M., T. Agner, Agner, T., Høgh, Julie Kaae, J.K. Høgh, Hellgren, Lars   +13 more
core   +1 more source

Poly(lactic‐co‐glycolic acid) microsphere loaded dissolving microneedles for sustained and coordinated transdermal delivery of desogestrel and ethinyl estradiol

Bulletin of the Korean Chemical Society, EarlyView.
PLGA‐based sustained‐release microneedles were developed for the delivery of desogestrel and ethinyl estradiol. The system enabled coordinated release of both drugs, suggesting its potential to improve dosing convenience as a long‐acting contraceptive platform.
Young‐Jin Kim, Byeongsu Kim, Sokyoung Joo, So‐Jeong Jeong, Chang‐Soo Han, Chun‐Woong Park   +5 more
wiley   +1 more source

Preparation of Liposomes from Stratum Corneum Lipids [PDF]

, 1986
Mammalian stratum corneum contains multiple intercellular lipid bilayers that contitute the epidermal water barrier. Unlike all other biologic membranes, the epidermal lamellae do not contain phospholipids, as a result of which the ability of the stratum
Downing, Donald T, Abraham, William, Wertz, Philip W, Landmann, Lukas   +3 more
core   +1 more source

6-Hydroxy-4-sphingenine in human epidermal ceramides.

Journal of Lipid Research, 1994
The solvent-extractable lipids of human epidermal stratum corneum consist predominantly of ceramides. In addition two non-extractable ceramides are chemically bound to the stratum corneum protein. One of the bound ceramides, constituting 50% of the bound
K J Robson, M E Stewart, S Michelsen, N D Lazo, D T Downing   +4 more
doaj   +1 more source