Results 61 to 70 of about 66,927 (286)

Structure Enhancement Relationship of Chemical Penetration Enhancers in Drug Transport across the Stratum Corneum

Pharmaceutics, 2012
The stratum corneum is a major barrier of drug penetration across the skin in transdermal delivery. For effective transdermal drug delivery, skin penetration enhancers are used to overcome this barrier.
Doungdaw Chantasart, S. Kevin Li
doaj   +1 more source

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1‐Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation

Advanced Science, EarlyView.
Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li, Chenli Si, Xue Wang, Xiaojin Wu, Ying Shang, Shengfang Ge, Yong Wang, Yong Zuo, Zhen Zhang   +8 more
wiley   +1 more source

Effect of different thickness of keratin layer of ductus papillaris on state of parenchyma in cow udder [PDF]

Veterinarski Glasnik, 2011
Ductus papillaris presents the frontline of defense of the mammary gland against the penetration of microorganisms into the milk cystern and the mammary gland parenchyma.
Davidov Ivana, Radinović Miodrag, Boboš Stanko, Mašić Zoran, Lalošević Dušan   +4 more
doaj   +1 more source

Deformation Driven Suction Cups: A Mechanics‐Based Approach to Wearable Electronics

Advanced Science, EarlyView.
Deformation‐driven suction cups enable robust, reversible adhesion of wearable electronics to human skin spanning wide mechanical compliance, without adhesives or tight straps. By integrating mechanics modeling, experiments, and contact mechanics theory, this work reveals how cup geometry, substrate compliance, and interfacial adhesion govern suction ...
Seola Lee, Andrew Akerson, Roham Pardakhtim, Ehsan Hajiesmaili, Kevin Rhodes, Zidong Li, Andrew Stanley, Amirhossein Amini, Daniele Piazza, Chiara Daraio, Tianshu Liu   +10 more
wiley   +1 more source

Utilizing Untargeted Lipidomics Technology to Elucidate Differences in Lipid Compositions Among Sensitive Dry, Sensitive Oily and Healthy Skin Types

Metabolites
Background: Sensitive skin exhibits impaired skin barrier function. The lipid composition of the skin, a pivotal element within the stratum corneum’s “brick-and-mortar” structure, plays a dual role: it is integral to cell differentiation processes and ...
Agui Xie, Xingjiang Zhang, Qing Huang, Jianxin Wu   +3 more
doaj   +1 more source

Degree of Skin Barrier Disruption Affects Lipid Organization in Regenerated Stratum Corneum

Acta Dermato-Venereologica, 2018
Previously, a skin barrier repair model was developed to examine the effect of formulations on the lipid properties of compromised skin. In this model, the lipid organization mimics that of several skin diseases with impaired skin barrier and less dense ...
Tineke Berkers, Dani Visscher, Gert S. Gooris, Joke A. Bouwstra   +3 more
doaj   +1 more source

Impact of Alkanediols on Stratum Corneum Lipids and Triamcinolone Acetonide Skin Penetration

Pharmaceutics, 2021
Alkanediols are widely used as multifunctional ingredients in dermal formulations. In addition to their preservative effect, considering their possible impact on drug penetration is also essential for their use.
Melanie Sigg, Rolf Daniels
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

TrichomeLess Regulator 3 is required for trichome initial and cuticle biosynthesis in Artemisia annua

Molecular Horticulture
Artemisinin is primarily synthesized and stored in the subepidermal space of the glandular trichomes of Artemisia annua. The augmentation of trichome density has been demonstrated to enhance artemisinin yield.
Boran Dong, Zihan Xu, Xingxing Wang, JinXing Li, Ying Xiao, Doudou Huang, Zongyou Lv, Wansheng Chen   +7 more
doaj   +1 more source

In vivo human skin penetration of (–)-epigallocatechin-3-gallate from topical formulations

Acta Pharmaceutica, 2014
The aim of the study was to examine the effect of topical vehicles on the in vivo human stratum corneum penetration of the antioxidant and skin photoprotective agent (-)-epigallocatechin-3-gallate (EGCG).
Scalia Santo, Trotta Valentina, Bianchi Anna   +2 more
doaj   +1 more source