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Principles and Properties of Stress Granules. [PDF]
Trends in Cell Biology, 2016 Stress granules are assemblies of untranslating messenger ribonucleoproteins (mRNPs) that form from mRNAs stalled in translation initiation. Stress granules form through interactions between mRNA-binding proteins that link together populations of mRNPs. Interactions promoting stress granule formation include conventional protein-protein interactions as
David S. W. Protter, R. Parker
semanticscholar +3 more sources
The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules. [PDF]
Molecular Cell, 2017 Stress granules are mRNA-protein assemblies formed from nontranslating mRNAs. Stress granules are important in the stress response and may contribute to some degenerative diseases. Here, we describe the stress granule transcriptome of yeast and mammalian cells through RNA-sequencing (RNA-seq) analysis of purified stress granule cores and single ...
A. Khong +5 more
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Genes and Diseases, 2022 Stress granules are non-membranous cytoplasmic foci induced by various stress conditions. It is a protective strategy used by cells to suppress overall translation during stress. In cancer cells, it was thought that the formation of stress granules could
Taobo Hu +3 more
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Localization to, and effects of Pbp1, Pbp4, Lsm12, Dhh1, and Pab1 on stress granules in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2010 The regulation of translation and mRNA degradation in eukaryotic cells involves the formation of cytoplasmic mRNP granules referred to as P-bodies and stress granules.
Kylie D Swisher, Roy Parker
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Chronic stress antagonizes formation of stress granules. [PDF]
iScienceAbstractChronic stress mediates cellular changes that can contribute to human disease. However, fluctuations in RNA metabolism caused by chronic stress have been largely neglected in the field. Stress granules (SGs) are cytoplasmic ribonucleoprotein condensates formed in response to stress-induced inhibition of mRNA translation and polysome disassembly.
Adachi Y +5 more
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Aspergillus oryzae AoSO is a novel component of stress granules upon heat stress in filamentous fungi. [PDF]
PLoS ONE, 2013 Stress granules are a type of cytoplasmic messenger ribonucleoprotein (mRNP) granule formed in response to the inhibition of translation initiation, which typically occurs when cells are exposed to stress.
Hsiang-Ting Huang +2 more
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Darinaparsin is a multivalent chemotherapeutic which induces incomplete stress response with disruption of microtubules and Shh signaling. [PDF]
PLoS ONE, 2011 Chemotherapeutics and other pharmaceuticals are common sources of cellular stress. Darinaparsin (ZIO-101) is a novel organic arsenical under evaluation as a cancer chemotherapeutic, but the drug's precise mechanism of action is unclear.
Twila A Mason +5 more
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Cell Reports, 2023 Summary: Membraneless condensates, such as stress granules (SGs) and processing bodies (P-bodies), have attracted wide attention due to their unique feature of rapid response to stress without first requiring nuclear feedback.
Ke Zhang +14 more
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Stress granules plug and stabilize damaged endolysosomal membranes
Nature, 2023 Endomembrane damage represents a form of stress that is detrimental for eukaryotic cells^ 1 , 2 . To cope with this threat, cells possess mechanisms that repair the damage and restore cellular homeostasis^ 3 – 7 .
Claudio Bussi +11 more
semanticscholar +1 more source
mRNPs meet stress granules [PDF]
FEBS Letters, 2017 Stress granules are cytoplasmic structures that form in response to a variety of cellular stresses. They contain mRNAs and many proteins including numerous types of RNA‐binding proteins, and have been studied in connection to major cellular events such as protein synthesis as well as disease. Despite the well‐known fact that stress granules encapsulate
Jonathan Sheinberger, Yaron Shav‐Tal
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