Results 241 to 250 of about 284,887 (285)

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Homologous Recombination in Thyroid Tumor Samples. [PDF]

Int J Mol Sci
Spirina LV, Tsyganov MM, Chizhevskaya SY, Tarasenko NV, Bogdanova VA.   +4 more
europepmc   +1 more source

Advancing Efficient Error Reduction in DNA Data Storage Systems with Deep Learning‐Based Denoising Models

Advanced Intelligent Discovery, EarlyView.
Deep learning‐based denoising models are applied to DNA data storage systems to enhance error reduction and data fidelity. By integrating DnCNN with DNA sequence encoding methods, the study demonstrates significant improvements in image quality and correction of substitution errors, revealing a promising path toward robust and efficient DNA‐based ...
Seongjun Seo, Anshula Tandon, Nguyen Kim Uyen, Quoc Nam Le, Jee‐Hyong Lee, Sung Ha Park   +5 more
wiley   +1 more source

Network toxicology and multiomics reveal bisphenol A-mediated immune evasion in breast cancer. [PDF]

J Int Med Res
Fang Y, Yan JL, Zhang W.
europepmc   +1 more source

Automated Discovery of Multicellular Behavior for Optimized Plant Growth and Climate Resilience

Advanced Intelligent Systems, EarlyView.
An automated robotic system is described for rapid scientific experimentation with multicellular organisms. By enhancing a robotic liquid handler with a custom developed deep learning algorithm and camera module, samples and data are prepared with minimal human intervention.
Mark A. DeAngelis, Philip R. LeDuc, Warren C. Ruder   +2 more
wiley   +1 more source

Antibacterial efficacy of Solanum muricatum aiton metabolites against methicillin-resistant staphylococcus aureus: Insights into bioactive compounds and molecular mechanisms. [PDF]

PLoS One
Samir S, Behery FA, Zarka MA, Bedaiwi RI, Abou-Zied HA, Abdelmohsen UR, Abd El-Baky RM, Mawhoup MA, Mahrous M, Abdelnaem RES, Bringmann G, Elmaidomy AH.   +11 more
europepmc   +1 more source

SmartDetectAI: An AI‐Powered Web App for Real‐Time Colorimetric Detection of Heavy Metals in Water

Advanced Intelligent Systems, EarlyView.
SmartDetectAI integrates silver nanoparticle‐based colorimetric sensing with an AI‐powered web app for rapid, on‐site detection of toxic heavy metals in water. By combining aggregation‐driven optical changes with machine learning analysis of red ‐ green ‐ blue values, the platform achieves portable, low‐cost, and accurate monitoring of Hg‐ and Cd‐based
Nishat Tasnim, Mirza M. A. Tunur, Fahad Arefin, Shahad Saroar, Md. Wahadoszamen, Taslim Ur Rashid, Aminul I. Talukder, Md. Nurul Amin, Mahmudur Rahman, Ahsan Habib   +9 more
wiley   +1 more source

Drug Repurposing for Kala-Azar. [PDF]

Pharmaceutics
Arsić B, Ilić BS, Maier A, Hartung M, Janjić J, Milićević J, Baumbach J.   +6 more
europepmc   +1 more source

Large‐Scale and Highly Reliable Hopfield Neural Networks Using Vertical NAND Flash Memory for the In‐Memory Associative Computing

Advanced Intelligent Systems, EarlyView.
Large‐scale Hopfield neural networks (HNNs) for associative computing are implemented using vertical NAND (VNAND) flash memory. The proposed VNAND HNN with the asynchronous update scenario achieve robust image restoration performance despite fabrication variations, while significantly reducing chip area (≈117× smaller than resistive random‐access ...
Jin Ho Chang, Jae Seung Woo, Suk‐Kang Sung, Ki‐Whan Song, Woo Young Choi   +4 more
wiley   +1 more source

Research on a Self-Powered Vibration Sensor for Coal Mine In Situ Stress Fracturing Drilling. [PDF]

Micromachines (Basel)
Liu J, Li M, Wu C, Shen X, Feng Y.
europepmc   +1 more source