Results 1 to 10 of about 604,769 (337)

Mesenchymal Stromal Cells Support Endometriotic Stromal Cells In Vitro [PDF]

Stem Cells International, 2018
Endometriosis is an inflammatory disease marked by ectopic growth of endometrial cells. Mesenchymal stromal cells (MSC) have immunosuppressive properties that have been suggested as a treatment for inflammatory diseases.
Fawaz Abomaray, Sebastian Gidlöf, Bartosz Bezubik, Mikael Engman, Cecilia Götherström   +4 more
doaj   +3 more sources

Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis

Journal for ImmunoTherapy of Cancer
Background The immunosuppressive tumor microenvironment reduces immune response effectiveness in stromal-rich tumors, including consensus molecular subtype 4 colorectal cancer (CRC).
Seán O Hynes, Laurence J Egan, Philip D Dunne, Oliver Treacy, Hannah Egan, Thomas Ritter, Margaret Sheehan, Aideen E Ryan, Linda Howard, Li Peng, Michael O’Dwyer, Lizhi Cao, Jenny Che, Shania M Corry, Niamh A Leonard, Aoife Canney, Eileen Reidy, Aoise O’Neill, Kevin Culligan, Norashikin Zakaria, Courtney Bull, Clodagh O’Meara, Anastasija Walsh, Aisling M Hogan   +23 more
doaj   +2 more sources

Differentiation of Human Embryonic Stem Cells into Cells with Corneal Keratocyte Phenotype [PDF]

, 2013
Corneal transparency depends on a unique extracellular matrix secreted by stromal keratocytes, mesenchymal cells of neural crest lineage. Derivation of keratocytes from human embryonic stem (hES) cells could elucidate the keratocyte developmental pathway
Chan, AA, Davoli, KA, Du, Y, Funderburgh, JL, Funderburgh, ML, Hertsenberg, AJ, Mann, MM, Mich-Basso, JD, Yang, L   +8 more
core   +15 more sources

Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells

eLife, 2022
Acute myeloid leukaemia (AML) cells interact and modulate components of their surrounding microenvironment into their own benefit. Stromal cells have been shown to support AML survival and progression through various mechanisms.
Nuria Vilaplana-Lopera, Vincent Cuminetti, Ruba Almaghrabi, Grigorios Papatzikas, Ashok Kumar Rout, Mark Jeeves, Elena González, Yara Alyahyawi, Alan Cunningham, Ayşegül Erdem, Frank Schnütgen, Manoj Raghavan, Sandeep Potluri, Jean-Baptiste Cazier, Jan Jacob Schuringa, Michelle AC Reed, Lorena Arranz, Ulrich L Günther, Paloma Garcia   +18 more
doaj   +1 more source

The Effect of Mesenchymal Stromal Cells Derived From Endometriotic Lesions on Natural Killer Cell Function

Frontiers in Cell and Developmental Biology, 2021
Endometriosis is an inflammatory disease that presents with ectopic endometriotic lesions. Reduced immunosurveillance of these lesions has been proposed to be playing a role in the pathology of endometriosis.
Fawaz Abomaray, Arnika Kathleen Wagner, Michael Chrobok, Åsa Ekblad-Nordberg, Sebastian Gidlöf, Sebastian Gidlöf, Evren Alici, Cecilia Götherström   +7 more
doaj   +1 more source

Stromal cells in the tumor microenvironment: accomplices of tumor progression?

Cell Death and Disease, 2023
The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular component), and cellular components include cancer cells and non-malignant cells such as immune cells and stromal cells.
Yan Zhao, Meili Shen, Liangqiang Wu, Haiqin Yang, Yixuan Yao, Qingbiao Yang, Jianshi Du, Linlin Liu, Yapeng Li, Yuansong Bai   +9 more
doaj   +1 more source

Spontaneous cancer-stromal cell fusion as a mechanism of prostate cancer androgen-independent progression. [PDF]

PLoS ONE, 2012
We have previously shown that human prostate cancer cells are capable of acquiring malignant attributes through interaction with stromal cells in the tumor microenvironment, while the interacting stromal cells can also become affected with both ...
Ruoxiang Wang, Xiaojuan Sun, Christopher Y Wang, Peizhen Hu, Chia-Yi Chu, Shurong Liu, Haiyen E Zhau, Leland W K Chung   +7 more
doaj   +1 more source

Umbilical cord mesenchymal stromal cells—from bench to bedside

Frontiers in Cell and Developmental Biology, 2022
In recent years, mesenchymal stromal cells (MSCs) have generated a lot of attention due to their paracrine and immuno-modulatory properties. mesenchymal stromal cells derived from the umbilical cord (UC) are becoming increasingly recognized as having ...
Shashank Chetty, Reza Yarani, Reza Yarani, Ganesh Swaminathan, Rosita Primavera, Shobha Regmi, Sravanthi Rai, Jim Zhong, Abantika Ganguly, Avnesh S Thakor   +9 more
doaj   +1 more source

Bone marrow mesenchymal stromal cell-derived small extracellular vesicles: A novel therapeutic agent in ischemic heart diseases

Frontiers in Pharmacology, 2023
Myocardial injury is a major pathological factor that causes death in patients with heart diseases. In recent years, mesenchymal stromal cells (MSCs) have been generally used in treating many diseases in animal models and clinical trials.
Wenguang Chang, Peifeng Li
doaj   +1 more source

Lymph Node Stromal Cells From Different Draining Areas Distinctly Regulate the Development of Chronic Intestinal Inflammation

Frontiers in Immunology, 2021
The balance between the responsiveness of the intestinal immune system and the gut environment is fundamental for the maintenance of intestinal homeostasis, which is required for an adequate recognition of entering antigens.
Marijana Basic, Pia Pascale Peppermüller, Silvia Bolsega, André Bleich, Melanie Bornemann, Ulrike Bode, Manuela Buettner, Manuela Buettner   +7 more
doaj   +1 more source