Advanced Science, EarlyView.This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu +17 more
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STIM/Orai-Mediated Store-Operated Ca<sup>2+</sup> Entry in the Pathogenesis of Fibrosis: Mechanisms and Therapeutic Opportunities. [PDF]
CellsYi Y +4 more
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Comprehensive analysis to develop a stromal senescence-associated gene signature for predicting hepatocellular carcinoma. [PDF]
Transl Cancer ResLu J, Zhang Z, Yuan W, Zhang Y.
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Single-Cell Transcriptomic Profiling and Machine Learning Integration Unveil Stromal Cell Heterogeneity in Endometriosis. [PDF]
Hum MutatZhang H, Luo Y.
europepmc +1 more source
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Cell Calcium, 2019A single calcium (Ca2+) binding site within the canonical EF-hand loop was thought to govern the stromal interaction molecule-1 (STIM1) structural changes that lead to activation of Orai1 Ca2+ channels. Recent work by Gudlur et al., published in Nat Commun [9(1):4536], suggests that the STIM1 endoplasmic reticulum (ER) luminal domain has ∼5 additional ...
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Relevance of stromal interaction molecule 1 (STIM1) in experimental and human stroke
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Role of Stromal Interaction Molecule 1 in Arteriogenesis
The FASEB Journal, 2020Introduction Arteriogenesis is a vital process for maintaining blood supply in the event of abrupt obstruction of perfusion such as cardiac ischemia. Here, we sought to determine whether stromal‐interaction molecule 1 (STIM1) is a key molecular mechanism involved in arteriogenesis.
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Interactions between the G Protein‐coupled Estrogen Receptor and the Stromal Interaction Molecule 1
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