The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli +3 more
wiley +1 more source
HorticulturaeImpatiens balsamina is a widely distributed ornamental plant known for its attractive floral colors and significant pharmaceutical value. Anthocyanins are responsible for the floral coloration of I. balsamina.
Jiayao Bian +8 more
doaj +1 more source
Transcriptome sequencing and analysis reveals the molecular response to selenium stimuli in Pueraria lobata (willd.) Ohwi [PDF]
PeerJ, 2020 Pueraria lobata (willd.) Ohwi is a consumable selenium-enriched plant used for medicinal purposes. The molecular response to selenium (Se) stimuli in P. lobata is currently unknown.
Kunyuan Guo +5 more
doaj +2 more sources
Global Gene Expression Analysis Identifies Age-Related Differences in Knee Joint Transcriptome during the Development of Post-Traumatic Osteoarthritis in Mice. [PDF]
, 2020 Aging and injury are two major risk factors for osteoarthritis (OA). Yet, very little is known about how aging and injury interact and contribute to OA pathogenesis.
Christiansen, Blaine A +7 more
core +2 more sources
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Genetic and developmental changes at early stages of chiropteran evolution: a brief review
Біологічні студії, 2010 Recent studies have revealed genetic and developmental changes responsible for the emergence of powered flight and echolocation at early stages of evolution in the bats (Chiroptera).
I. I. Dzeverin
doaj +1 more source
BMC Genomics, 2023 Comprehensive analysis of multiple data sets can identify potential driver genes for various cancers. In recent years, driver gene discovery based on massive mutation data and gene interaction networks has attracted increasing attention, but there is ...
Xin Chu +5 more
doaj +1 more source
Chromosomal control of wheat endosperm proteins. A critical review. [PDF]
, 1977 Progress made in the chromosomal location of structural genes for wheat endosperm proteins, and in the study of the regulation and quantitative expression of these genes, by using aneuploids and by related techniques, is critically evaluated ...
Aragoncillo Ballesteros, Cipriano +3 more
core +2 more sources
Comparing large covariance matrices under weak conditions on the dependence structure and its application to gene clustering [PDF]
, 2016 Comparing large covariance matrices has important applications in modern genomics, where scientists are often interested in understanding whether relationships (e.g., dependencies or co-regulations) among a large number of genes vary between different ...
Chang, Jinyuan +3 more
core +2 more sources
An integrated map of structural variation in 2,504 human genomes
Nature, 2015 Structural variants are implicated in numerous diseases and make up the majority of varying nucleotides among human genomes. Here we describe an integrated set of eight structural variant classes comprising both balanced and unbalanced variants, which we
Peter Sudmant +81 more
semanticscholar +1 more source