Results 61 to 70 of about 17,611 (220)
Tissue Responses to Shiga Toxin in Human Intestinal OrganoidsSummary
Cellular and Molecular Gastroenterology and Hepatology, 2020 Background & Aims: Shiga toxin (Stx)-producing Escherichia coli (eg, O157:H7) infection produces bloody diarrhea, while Stx inhibits protein synthesis and causes the life-threatening systemic complication of hemolytic uremic syndrome.
Suman Pradhan +7 more
doaj +1 more source
Survey on Visualization of Information Diffusion over Networks
Computer Graphics Forum, EarlyView.Abstract Information Diffusion (ID) describes how a value (e.g., a pathogen, a rumor, a packet) spreads through an underlying “medium” network of elements (e.g., a social or computer network). Understanding the information diffusion process is essential to predicting trends, controlling misinformation, and enhancing decision‐making as well as ...
T. Baumgartl +8 more
wiley +1 more source
A Rapid and Sensitive Method to Measure the Functional Activity of Shiga Toxins in Human Serum
Toxins, 2015 Shiga toxins (Stx) have a definite role in the development of hemolytic uremic syndrome in children with hemorrhagic colitis caused by pathogenic Stx-producing Escherichia coli (STEC) strains. The dramatic effects of these toxins on the microvasculature
Valentina Arfilli +5 more
doaj +1 more source
The FEBS Journal, EarlyView.Chromosomal DNA double‐strand breaks (DSBs) are repaired by homologous recombination and nonhomologous end joining (NHEJ). Recent work has additionally established theta‐mediated end‐joining (TMEJ) as a mechanism for DSB joining. Cells lacking NHEJ and TMEJ can repair DSBs in a homology‐dependent manner.
Shinta Saito +6 more
wiley +1 more source
Marine Drugs, 2023 Harmful algal blooms (HABs) can produce a variety of noxious effects and, in some cases, the massive mortality of wild and farmed marine organisms. Some HAB species produce toxins that are released into seawater or transferred via food webs (particulate ...
Colleen Guinle +4 more
doaj +1 more source
Effects ofSaxitoxin (STX) and Veratridine on BacterialNa + -K + Fluxes: a Prokaryote-BasedSTXBioassay [PDF]
Applied and Environmental Microbiology, 2003 ABSTRACT Saxitoxin (STX) is a potent natural sodium channel blocker and represents a significant health concern worldwide. We describe here the antagonistic effects of STX and veratridine (VTD), an Na + channel activator, on three gram-negative bacteria and their application to an STX bioassay. STX reduced
F. Pomati +3 more
openaire +3 more sources
Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy
Immunology &Cell Biology, EarlyView.IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley +1 more source
Proteasome inhibitors prevent cell death and prolong survival of mice challenged by Shiga toxin
FEBS Open Bio, 2015 Shiga toxin (Stx) causes fatal systemic complications. Stx induces apoptosis, but the mechanism of which is unclear. We report that Stx induced rapid reduction of short‐lived anti‐apoptotic proteins followed by activation of caspase 9 and the progression
Takayuki Hattori +6 more
doaj +1 more source
Rapid and Simple Method for the Detection of Shigatoxins (STxs)
Journal of the Japanese Association for Infectious Diseases, 1999 Enterohemorrhagic Escherichia coli (EHEC) is an emerged bacterial agent as the cause of bloody diarrhea and a leading cause of hemolytic uremic syndrome in children. In our country, serotype O 157:H7 is the predominant pathogen in the EHEC and the most frequently seen in human infections.
KOBAYASHI, Kazuhiro +2 more
openaire +3 more sources
Robust Estimation and Inference for Time‐Varying Unconditional Volatility
Journal of Time Series Analysis, EarlyView.ABSTRACT We derive a general and robust estimator of a large class of parametric specifications of time‐varying unconditional volatility of financial returns, both univariate and multivariate, and establish the Consistency and Asymptotic Normality (CAN) of the estimator.
Adam Lee +2 more
wiley +1 more source