Results 231 to 240 of about 155,734 (309)

Synaptotagmin 1 and Synaptotagmin 7 promote MR1-mediated presentation of <i>Mycobacterium tuberculosis</i> antigens. [PDF]

Elife
Kim SJ, Peterson JC, Olive AJ, Tafesse FG, Kulicke CA, Karamooz E, Lewinsohn D.   +6 more
europepmc   +1 more source

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Localization of Organelle Proteins Using Data-Independent Acquisition (DIA-LOP). [PDF]

Mol Cell Proteomics
McCaskie K, Hutchings C, Feret R, Kim YI, Breckels L, Deery M, Lilley K.   +6 more
europepmc   +1 more source

Semiconducting Polymer Nanoparticles Enable Light‐Controlled Bidirectional Modulation of Nitric Oxide in Endothelial Cells

Advanced Science, EarlyView.
Bimodal modulation of nitric oxide in endothelial cells is achieved by light‐sensitive polymer nanoparticles. In dark, P3HT/PEDOT:PSS NPs boost intracellular ·NO, upregulate both endothelial and induced nitric oxide synthase, and drive a metabolic shift toward glycolysis.
Camilla Marzuoli, Andrea Pianetti, Elena Mancinelli, Anthea Villano, Matteo Vailati, Paola Lagonegro, Miryam Criado‐Gonzalez, Montserrat Climent, Hansel Comas‐Rojas, Leonardo Elia, Francesco Moccia, Gabriele Tullii, Maria Rosa Antognazza   +12 more
wiley   +1 more source

Regulation of YAP activity by nuclear G-actin binding. [PDF]

Nucleic Acids Res
Wang H, Jayawardana IM, Fleisch JM, Frank D, Zhao B, Kamaras C, Gebhardt P, Knerr J, Ulferts S, Sivabalasarma S, Albers SV, Grosse R.   +11 more
europepmc   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source

BIP orchestrates bidirectional ER protein trafficking via co-chaperone complexes. [PDF]

Cell Mol Biol Lett
Biadsy S, Gilad A, Madegam LA, Igbaria A.   +3 more
europepmc   +1 more source

KCC2 phosphorylation dynamics relate to oligomerization during development and after spinal cord injury. [PDF]

Front Mol Neurosci
Liabeuf S, Brocard C, Coq JO, Vinay L, Brocard F.   +4 more
europepmc   +1 more source

Subcellular proteomics reveals a blueprint for endosymbiont integration in trypanosomatid Angomonas deanei. [PDF]

Nat Commun
Hammond M, Chmelová Ľ, van Geelen-Kuenzel NA, Maurya AK, Ferreira ER, Puente V, Cadena LR, Záhonová K, Dowle A, Mottram JC, Nowack ECM, Lukeš J, Yurchenko V.   +12 more
europepmc   +1 more source

Subcellular Mechanisms of Se(IV) Reduction in Stenotrophomonas bentonitica: Linking Environmental Detoxification and Antimicrobial Activity of Se Nanostructures Within a Circular Economy Framework. [PDF]

Microb Biotechnol
Lazúen-López G, Pérez-Muelas E, Ruiz-Fresneda MA, Van Lithaut A, Lazúen-Alcon J, Merroun ML.   +5 more
europepmc   +1 more source