Results 31 to 40 of about 7,622 (205)

Succinylation and redox status in cancer cells

Frontiers in Oncology, 2022
Succinylation is a post-translational modification (PTM) event that associates metabolic reprogramming with various pathological disorders including cancers via transferring a succinyl group to a residue of the target protein in an enzymic or non-enzymic
Xiaofeng Dai, Yanyan Zhou, Fei Han, Jitian Li   +3 more
doaj   +1 more source

Peptide inhibitors of Streptomyces DD-carboxypeptidases [PDF]

, 1973
1. Peptides that inhibit the dd-carboxypeptidases from Streptomyces strains albus G and R61 were synthesized. They are close analogues of the substrates of these enzymes.
Frère, Jean-Marie, Ghuysen, Jean-Marie, Leyh-Bouille, Mélina, Nieto, Manuel, Perkins, Harnold R.   +4 more
core   +1 more source

MDCAN-Lys: A Model for Predicting Succinylation Sites Based on Multilane Dense Convolutional Attention Network

Biomolecules, 2021
Lysine succinylation is an important post-translational modification, whose abnormalities are closely related to the occurrence and development of many diseases.
Huiqing Wang, Hong Zhao, Zhiliang Yan, Jian Zhao, Jiale Han   +4 more
doaj   +1 more source

SIRT5-RAC2 Axis Drives Monocyte-to-Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency. [PDF]

Adv Sci (Weinh)
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
TanTai W, Li Y, Liu S, Wu M, Liu Z, Jiang J, Chen J, Xu X, Li L, Li C, Zhao F, Liu Y, Ni H, Zhang T, Xu M, Han C.   +15 more
europepmc   +2 more sources

The Plant PTM Viewer, a central resource for exploring plant protein modifications [PDF]

, 2019
Posttranslational modifications (PTMs) of proteins are central in any kind of cellular signaling. Modern mass spectrometry technologies enable comprehensive identification and quantification of various PTMs.
Botzki, Alexander, De Smet, Ive, Gevaert, Kris, Goormachtig, Sofie, Horne, Alison, Van Breusegem, Frank, Van Parys, Thomas, Willems, Patrick   +7 more
core   +1 more source

Tandem mass tag-based quantitative proteomic analysis identification of succinylation related proteins in pathogenesis of thoracic aortic aneurysm and aortic dissection [PDF]

PeerJ, 2023
Background Thoracic aortic aneurysm and dissection (TAAD) are devastating cardiovascular diseases with a high rate of disability and mortality. Lysine succinylation, a newly found post-translational modification, has been reported to play an important ...
Yu Zhang, Hongwei Zhang, Haiyue Wang, Chenhao Wang, Peng Yang, Chen Lu, Yu Liu, Zhenyuan Xu, Yi Xie, Jia Hu   +9 more
doaj   +2 more sources

Mycobacterium tuberculosis H37Ra: a surrogate for the expression of conserved, multimeric proteins of M.tb H37Rv [PDF]

, 2016
Additional file 3. Details of primers used, experimental and theoretical molecular weights, pI values and details of post-translational modifications in ...
Ajay Kumar, Ankit Sahu, Anushri Agnihotri, Chaaya Iyengar Raje, Himanshu Malhotra, Kalpesh Kumar Rajwadi, Manoj Kumar, Manoj Raje, Navdeep Sheokand, Naveen Bhagath, Navi Hasan, Pravinkumar Patil, Rachita Patkar, Vishant Mahendra Boradia   +13 more
core   +5 more sources

Systematic identification and comparative analysis of lysine succinylation between the green and white parts of chimeric leaves of Ananas comosus var. bracteatus

BMC Genomics, 2020
Background Lysine succinylation, an important protein posttranslational modification (PTM), is widespread and conservative. The regulatory functions of succinylation in leaf color has been reported. The chimeric leaves of Ananas comosus var.
Meiqin Mao, Yanbin Xue, Yehua He, Xuzixing Zhou, Fatima Rafique, Hao Hu, Jiawen Liu, Lijun Feng, Wei Yang, Xi Li, Lingxia Sun, Zhuo Huang, Jun Ma   +12 more
doaj   +1 more source

Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease

Nature Communications, 2022
Succinylation is a metabolism-associated post-translational protein modification. Here the authors describe changes to the succinylation of proteins in the brain of individuals with Alzheimer’s disease.
Yun Yang, Victor Tapias, Diana Acosta, Hui Xu, Huanlian Chen, Ruchika Bhawal, Elizabeth T. Anderson, Elena Ivanova, Hening Lin, Botir T. Sagdullaev, Jianer Chen, William L. Klein, Kirsten L. Viola, Sam Gandy, Vahram Haroutunian, M. Flint Beal, David Eliezer, Sheng Zhang, Gary E. Gibson   +18 more
doaj   +1 more source

Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies [PDF]

, 2015
published_or_final_versio
Aramsangtienchai, P, Hao, Q, He, B, Hu, J, Jing, H, Khan, S, Lin, H, Teng, YB   +7 more
core   +1 more source