Results 61 to 70 of about 7,622 (205)

Proteomics and succinylation modification characterization in clear cell renal cell carcinoma

Discover Oncology
Clear cell renal cell carcinoma (ccRCC) represents the most lethal form of kidney cancer, with a significant number of patients experiencing tumor progression.
Dong Yue, Miao Zheng
doaj   +1 more source

Succinylation-related molecular activities in cancer: metabolic adaptations, immune landscape, and prognostic significance in colorectal cancer

Frontiers in Immunology
BackgroundSuccinylation, a key post-translational modification, plays a crucial role in metabolic regulation and tumor progression. However, its influence on the tumor immune microenvironment and its prognostic implications remain unclear.
Zhihang Jiang, Zhihang Jiang, Xiaoqing Li, Xiaoqing Li, Long Hu, Zheng Jiang   +5 more
doaj   +1 more source

epigenetic proteins and RNAs find a new focus [PDF]

, 2013
We welcome you to a special issue of Neurotherapeutics that highlights much of the exciting new thinking behind a burgeoning and therapeutically relevant topic—epigenetic proteins in psychiatric and neurological disease.
Basso, Manuela, Ratan, Rajiv R., Sleiman, Sama   +2 more
core   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, EarlyView.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

C-C Bond formation catalyzed by natural gelatin and collagen proteins [PDF]

, 2013
The activity of gelatin and collagen proteins towards C–C bond formation via Henry (nitroaldol) reaction between aldehydes and nitroalkanes is demonstrated for the first time.
Cativiela, Carlos Alberto, Dhar, Basab Bijayi, Díaz Díaz, David, Gotor Fernández, Vicente, Kuehbeck, Dennis, Schoen, Eva María   +5 more
core   +2 more sources

Application Strategies of Bone Marrow Mesenchymal Stromal Cells in Bone‐Related Diseases

Cell Proliferation, EarlyView.
Engineered BMSCs and vesicles enhance therapy effects for bone diseases via multi‐strategic approaches. ABSTRACT Bone‐related diseases (e.g., osteoporosis, osteoarthritis and fractures) exhibit a rising global incidence, imposing significant burdens on both quality of life and healthcare systems.
Xuemei Long, Dan Tan, Qianke Tao, Qiaonan Ye, Luwen Ye, Qing Li, Jingang Xiao   +6 more
wiley   +1 more source

Dysregulation of protein succinylation and disease development

Frontiers in Molecular Biosciences
As a novel post-translational modification of proteins, succinylation is widely present in both prokaryotes and eukaryotes. By regulating protein translocation and activity, particularly involved in regulation of gene expression, succinylation actively ...
Xiaoli Hou, Lijuan Zhu, Haiying Xu, Jie Shi, Shaoping Ji, Shaoping Ji   +5 more
doaj   +1 more source

Vegetable proteins in microencapsulation: a review of recent interventions and their effectiveness [PDF]

, 2013
Proteins from vegetable seeds are interesting for research at present because they are an abundant alternative to animal-based sources of proteins and petroleum-derived polymers.
Alric, Isabelle, Durrieu, Vanessa, Nesterenko, Alla, Silvestre, Françoise   +3 more
core   +1 more source

Lactylation Reprogramming in the Bone Infection Microenvironment Identifies PGK1 K361 as a Potential Therapeutic Target for Osteogenic Dysfunction

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Staphylococcus aureus (S. aureus) infection creates a high‐lactate microenvironment, promoting p300‐mediated lactylation of PGK1 at lysine 361 (K361). Lactylated PGK1 translocates to the mitochondrial outer membrane and interacts with VDAC3. This interaction triggers FtMt downregulation, iron accumulation, and excessive PINK1/Parkin‐mediated mitophagy,
Han‐jun Qin, Si‐ying He, Ting‐hui Xiao, Da‐mao Dai, Xin‐jia Hu, Nan Jiang   +5 more
wiley   +1 more source

Human Citrate Synthase Post‐Translational Modification Mimics and Molecular Dynamic Simulations Demonstrate Attenuation of Acetyl‐CoA/CoA Binding

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 4, Page 883-892, April 2026.
ABSTRACT Human citrate synthase (hCS) is a mitochondrial enzyme that catalyzes the aldol condensation of acetyl coenzyme A (AcCoA) to oxaloacetate to form citrate in the TCA cycle. CS activity is important for aerobic exercise performance and basic metabolic function as a housekeeping enzyme.
Noah Shackelford, Zach Zavodny, Nathan Fancher, Michael A. Moxley   +3 more
wiley   +1 more source