Results 31 to 40 of about 587 (147)

Paulownia Witches' Broom Disease: A Comprehensive Review. [PDF]

Microorganisms
Phytoplasmas are insect-transmitted bacterial pathogens associated with diseases in a wide range of host plants, resulting in significant economic and ecological losses.
Zhang Y, Qiao Z, Li J, Bertaccini A.
europepmc   +3 more sources

Comprehensive analysis of the lysine succinylome in fish oil-treated prostate cancer cells. [PDF]

Life Sci Alliance, 2023
Prostate cancer (PCa) poses a significant health threat to males, and research has shown that fish oil (FO) can impede PCa progression by activating multiple mitochondria-related pathways. Our research is focused on investigating the impact of FO on succinylation, a posttranslational modification that is closely associated with mitochondria in PCa ...
Jiang Y, He C, Ye H, Xu Q, Chen X, Chen Y, Sun J, Rocha S, Wang M.   +8 more
europepmc   +3 more sources

The yeast mitochondrial succinylome: Implications for regulation of mitochondrial nucleoids. [PDF]

J Biol Chem, 2021
Acylation modifications, such as the succinylation of lysine, are post-translational modifications and a powerful means of regulating protein activity. Some acylations occur nonenzymatically, driven by an increase in the concentration of acyl group donors.
Frankovsky J, Keresztesová B, Bellová J, Kunová N, Čanigová N, Hanakova K, Bauer JA, Ondrovičová G, Lukáčová V, Siváková B, Zdrahal Z, Pevala V, Procházková K, Nosek J, Baráth P, Kutejova E, Tomaska L.   +16 more
europepmc   +4 more sources

SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks [PDF]

Cell Metabolism, 2013
Reversible posttranslational modifications are emerging as critical regulators of mitochondrial proteins and metabolism. Here, we use a label-free quantitative proteomic approach to characterize the lysine succinylome in liver mitochondria and its regulation by the desuccinylase SIRT5.
Rardin, Matthew J, He, Wenjuan, Nishida, Yuya, Newman, John C, Carrico, Chris, Danielson, Steven R, Guo, Ailan, Gut, Philipp, Sahu, Alexandria K, Li, Biao, Uppala, Radha, Fitch, Mark, Riiff, Timothy, Zhu, Lei, Zhou, Jing, Mulhern, Daniel, Stevens, Robert D, Ilkayeva, Olga R, Newgard, Christopher B, Jacobson, Matthew P, Hellerstein, Marc, Goetzman, Eric S, Gibson, Bradford W, Verdin, Eric   +23 more
openaire   +7 more sources

Conjoint analysis of succinylome and phosphorylome reveals imbalanced HDAC phosphorylation-driven succinylayion dynamic contibutes to lung cancer. [PDF]

Brief Bioinform
Abstract Cancerous genetic mutations result in a complex and comprehensive post-translational modification (PTM) dynamics, in which protein succinylation is well known for its ability to reprogram cell metabolism and is involved in the malignant evolution.
Guo Y, Wen H, Chen Z, Jiao M, Zhang Y, Ge D, Liu R, Gu J.   +7 more
europepmc   +3 more sources

Heat Shock Strengthens the Protective Potential of MSCs in Liver Injury by Promoting EV Release Through Upregulated Autophagosome Formation. [PDF]

J Extracell Vesicles
ABSTRACT Mesenchymal stem cell‐derived extracellular vesicles (MSC‐EVs) show powerful potential in the treatment of multiple diseases. However, the low yield of MSC‐EVs severely restricts their clinical application. Here, heat shock (HS), a moderate external stimulus, can enhance EVs release of MSCs by upregulating autophagosome formation ...
Wang T, Gong Y, Lin H, Li X, Liang J, Yuan X, Li C, Hu Z, Chen H, Xiao J, Zhang J, Liu Y, Yan X, Jiang C, Yao J, Zhang Q, Li R, Zheng J.   +17 more
europepmc   +2 more sources

Proteome, Lysine Acetylome, and Succinylome Identify Posttranslational Modification of STAT1 as a Novel Drug Target in Silicosis. [PDF]

Mol Cell Proteomics
يؤدي استنشاق غبار السيليكا البلوري إلى تلف الرئة غير القابل للشفاء والسحار السيليسي والتليف الرئوي. ومع ذلك، لا تزال آليات إصابة الرئة غير مفهومة بشكل جيد، مع خيارات علاجية محدودة بصرف النظر عن زراعة الرئة. يمكن أن تنظم تعديلات ما بعد الترجمة وظيفة البروتينات وتلعب دورًا مهمًا في دراسة آليات المرض.
Zhang T, Wang Y, Sun Y, Song M, Pang J, Wang M, Zhang Z, Yang P, Chen Y, Qi X, Zhou H, Han Z, Xing Y, Liu Y, Li B, Liu J, Yang J, Wang J.   +17 more
europepmc   +3 more sources

Proteome-Wide Identification of Lysine Succinylation in the Proteins of Tomato (Solanum lycopersicum). [PDF]

PLoS ONE, 2016
Post-translational modification of proteins through lysine succinylation plays important regulatory roles in living cells. Lysine succinylation was recently identified as a novel post-translational modification in Escherichia coli, yeast, Toxoplasma ...
Weibo Jin, Fangli Wu
doaj   +1 more source

Multi‐omic analyses and network biology in cardiovascular disease

PROTEOMICS, Volume 23, Issue 21-22, November 2023., 2023
Abstract Heart disease remains a leading cause of death in North America and worldwide. Despite advances in therapies, the chronic nature of cardiovascular diseases ultimately results in frequent hospitalizations and steady rates of mortality. Systems biology approaches have provided a new frontier toward unraveling the underlying mechanisms of cell ...
Cristine J. Reitz, Uros Kuzmanov, Anthony O. Gramolini   +2 more
wiley   +1 more source

Global profiling of lysine succinylation in human lungs

PROTEOMICS, Volume 22, Issue 17, September 2022., 2022
Abstract The lysine succinylation (Ksucc) is involved in many core energy metabolism pathways and affects the metabolic process in mitochondria, making this modification highly valuable for studying diseases related to mitochondrial disorders. In this paper, we used liquid chromatography with tandem mass spectrometry (LC‐MS/MS) to perform the first ...
Ye‐Hong Yang, Song‐Feng Wu, Yun‐Ping Zhu, Jun‐Tao Yang, Jiang‐Feng Liu   +4 more
wiley   +1 more source