Post‐translational modifications drive secondary metabolite biosynthesis in Aspergillus: a review
Environmental Microbiology, Volume 24, Issue 7, Page 2857-2881, July 2022., 2022 Summary Post‐translational modifications (PTMs) are important for protein function and regulate multiple cellular processes and secondary metabolites (SMs) in fungi. Aspergillus species belong to a genus renown for an abundance of bioactive secondary metabolites, many important as toxins, pharmaceuticals and in industrial production. The genes required
Kunlong Yang, Jun Tian, Nancy P. Keller
wiley +1 more source
Quantitative succinylome analysis in the liver of non-alcoholic fatty liver disease rat model [PDF]
Proteome Science, 2016 Non-alcoholic fatty liver disease (NAFLD) is a clinical frequent disease. However, its pathogenesis still needs further study, especially the mechanism at the molecular level. The recent identified novel protein post-translational modification, lysine succinylation was reported involved in diverse metabolism and cellular processes.
Cheng, Yang +4 more
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Systematic Proteome and Lysine Succinylome Analysis Reveals Enhanced Cell Migration by Hyposuccinylation in Esophageal Squamous Cell Carcinoma [PDF]
Molecular & Cellular Proteomics, 2021 Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with poor therapeutic outcomes. However, the alterations in proteins and posttranslational modifications (PTMs) leading to the pathogenesis of ESCC remain unclear. Here, we provide the comprehensive characterization of the proteome, phosphorylome, lysine acetylome, and succinylome ...
Zhenchang Guo +17 more
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Segmental aging underlies the development of a Parkinson phenotype in the AS/AGU rat [PDF]
, 2016 There is a paucity of information on the molecular biology of aging processes in the brain. We have used biomarkers of aging (SA β-Gal, p16Ink4a, Sirt5, Sirt6, and Sirt7) to demonstrate the presence of an accelerated aging phenotype across different ...
Khojah, Sohair M. +3 more
core +2 more sources
Overexpression of mitochondrial sirtuins alters glycolysis and mitochondrial function in HEK293 cells [PDF]
, 2014 SIRT3, SIRT4, and SIRT5 are mitochondrial deacylases that impact multiple facets of energy metabolism and mitochondrial function. SIRT3 activates several mitochondrial enzymes, SIRT4 represses its targets, and SIRT5 has been shown to both activate and ...
De Moura, MB +4 more
core +2 more sources
Sirtuin 5 depletion impairs mitochondrial function in human proximal tubular epithelial cells [PDF]
, 2021 Ischemia is a major cause of kidney damage. Proximal tubular epithelial cells (PTECs) are highly susceptible to ischemic insults that frequently cause acute kidney injury (AKI), a potentially life-threatening condition with high mortality.
Anderson, G +6 more
core +1 more source
Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies [PDF]
, 2015 published_or_final_versio
Aramsangtienchai, P +7 more
core +1 more source
Crosstalk among proteome, acetylome and succinylome in colon cancer HCT116 cell treated with sodium dichloroacetate [PDF]
Scientific Reports, 2016 AbstractProtein lysine acetylation and succinylation play important regulatory roles in cells, both of which or each other has a close relationship. Dichloroacetate (DCA), a well-known pyruvate dehydrogenase kinase (PDK) inhibitor, has the potential to be used as anti-cancer drugs for several tumors including colorectal cancer. However, little is known
Danxi Zhu +6 more
openaire +2 more sources
SIRTain regulators of premature senescence and accelerated aging. [PDF]
, 2015 The sirtuin proteins constitute class III histone deacetylases (HDACs). These evolutionarily conserved NAD(+)-dependent enzymes form an important component in a variety of cellular and biological processes with highly divergent as well as convergent ...
Ghosh, S, Zhou, Z
core +1 more source
Sirtuins: to be or not to be in diabetic cardiomyopathy [PDF]
, 2021 Diabetic cardiomyopathy is the leading cause of death among people with diabetes. Despite its severity and poor prognosis, there are currently no approved specific drugs to prevent or even treat diabetic cardiomyopathy. There is a need to understand the
Aguilar-Recarte, David +4 more
core +1 more source