Results 61 to 70 of about 587 (147)

Deficiency in Protein Tyrosine Phosphatase PTP1B shortens lifespan and leads to development of acute leukemia [PDF]

, 2018
This work was performed with the funds from the Wellcome Trust ISSF grant to M. Delibegovic and BHF project grant to M. Delibegovic (PG/11/8/28703). S. Le Sommer is a recipient of the University of Aberdeen Institute of Medical Sciences PhD studentship ...
Bence, Kendra K., Delibegović, Mirela, Le Sommer, Samantha, Mody, Nimesh, Morrice, Nicola, Murray, Graeme I., Neel, Benjamin G., Pesaresi, Martina, Thompson, Dawn, Vickers, Mark A., Wilson, Heather M.   +10 more
core   +3 more sources

Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia [PDF]

, 2014
Nonalcoholic fatty liver disease (NAFLD) spectrum disorders affect approximately 1 billion individuals worldwide. However, the drivers of progressive steatohepatitis remain incompletely defined.
Baris Ercal, Befroy, Chen, D. André d’Avignon, David G. Cotter, Dennis J. Dietzen, Elizabeth M. Brunt, Gary J. Patti, Hegardt, Jamison M. Leid, Jitrapakdee, Kanehisa, Mark J. Graham, Peter A. Crawford, Robinson, Sengupta, Serviddio, Soeters, Tautenhahn, Thumelin, Thurston, Williamson, Williamson, Williamson, Williamson, Wolf, Xiaojing Huang   +26 more
core   +2 more sources

SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense [PDF]

, 2016
Excess in mitochondrial reactive oxygen species (ROS) is considered as a major cause of cellular oxidative stress. NADPH, the main intracellular reductant, has a key role in keeping glutathione in its reduced form GSH, which scavenges ROS and thus ...
Chen, Xiufei, Guan, Kun-Liang, Sun, Renqiang, Wang, Fang, Wang, Shiwen, Wang, Yi, Xiong, Yue, Xu, Qi, Yang, Pengyuan, Ye, Dan, Yu, Hongxiu, Zhang, Mengli, Zhou, Lisha   +12 more
core   +2 more sources

Comprehensive Analysis of the Lysine Succinylome and Protein Co-modifications in Developing Rice Seeds

Molecular & Cellular Proteomics, 2019
Lysine succinylation has been recognized as a post-translational modification (PTM) in recent years. It is plausible that succinylation may have a vaster functional impact than acetylation because of bulkier structural changes and more significant charge differences on the modified lysine residue.
Xiaoxi, Meng, Hana, Mujahid, Yadong, Zhang, Xiaojun, Peng, Edilberto D, Redoña, Cailin, Wang, Zhaohua, Peng   +6 more
openaire   +2 more sources

Proteome and Acetyl-Proteome Profiling of Camellia sinensis cv. ‘Anji Baicha’ during Periodic Albinism Reveals Alterations in Photosynthetic and Secondary Metabolite Biosynthetic Pathways

Frontiers in Plant Science, 2017
Tea leaf color is not only important from an aesthetics standpoint but is also related to tea quality. To investigate the molecular mechanisms that determine tea leaf color, we examined Camellia sinensis cv.
Yan-Xia Xu, Wei Chen, Chun-Lei Ma, Si-Yan Shen, Yan-Yan Zhou, Lian-Qi Zhou, Liang Chen   +6 more
doaj   +1 more source

Oxidative stress‐triggered interactions between the succinyl‐ and acetyl‐proteomes of rice leaves [PDF]

, 2018
Protein lysine acylations, such as succinylation and acetylation, are important post‐translational modification (PTM) mechanisms, with key roles in cellular regulation.
Aebi, Allfrey, Arnold, Biasini, Chen, Chen, Choudhary, Colak, Couturier, Dimmer, Du, Fang, Finkemeier, Glozak, Go, Hancock, Hartl, He, Horton, Hosp, Huang, Huang, Jin, Jones, Kosono, König, König, Lebedev, Li, Liao, Melo-Braga, Mhamdi, Miller, Mitchell, Moriya, Nallamilli, Pan, Pan, Park, Paulsen, Rao, Rosen, Shannon, Shen, Smith-Hammond, Szklarczyk, Tyanova, Venkat, Wagner, Wu, Xie, Xie, Xing, Xiong, Zhang, Zhang, Zhang, Zhao, Zhen   +58 more
core   +2 more sources

Improving protein succinylation sites prediction using embeddings from protein language model [PDF]

, 2022
Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including cellular respiration, regulation, and repair.
Heinzinger, Michael, KC, Dukka, Newman, Robert H., Pokharel, Suresh, Pratyush, Pawel   +4 more
core   +3 more sources

Quantitative Succinyl-Proteome Profiling of Camellia sinensis cv. ‘Anji Baicha’ During Periodic Albinism

Scientific Reports, 2017
Lysine succinylation is a novel dynamic and evolutionarily conserved post-translational modification (PTM) that regulates various biological processes. ‘Anji Baicha’ is an albino tea variety that exhibits temperature-based variability of leaf colour and ...
Yan-Xia Xu, Chen-Jia Shen, Jian-Qiang Ma, Wei Chen, Juan Mao, Yan-Yan Zhou, Liang Chen   +6 more
doaj   +1 more source

Succinylome Analysis Reveals the Involvement of Lysine Succinylation in Metabolism in Pathogenic Mycobacterium tuberculosis*

Molecular & Cellular Proteomics, 2015
Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis, remains one of the most prevalent human pathogens and a major cause of mortality worldwide. Metabolic network is a central mediator and defining feature of the pathogenicity of Mtb.
Mingkun, Yang, Yan, Wang, Ying, Chen, Zhongyi, Cheng, Jing, Gu, Jiaoyu, Deng, Lijun, Bi, Chuangbin, Chen, Ran, Mo, Xude, Wang, Feng, Ge   +10 more
openaire   +2 more sources

The decrotonylase FoSir5 facilitates mitochondrial metabolic state switching in conidial germination of Fusarium oxysporum. [PDF]

, 2021
Fusarium oxysporum is one of the most important pathogenic fungi with a broad range of plant and animal hosts. The first key step of its infection cycle is conidial germination, but there is limited information available on the molecular events ...
Liang, Wenxing, Luisi, Ben F, Pei, Xueyuan, Song, Limin, Xu, Yang, Zhang, Ning   +5 more
core   +2 more sources