Results 121 to 130 of about 1,568 (147)

Protective effects of the succinate/SUCNR1 axis on damaged hepatocytes in NAFLD

Metabolism: Clinical and Experimental, 2023
Succinate and succinate receptor 1 (SUCNR1) are linked to fibrotic remodeling in models of non-alcoholic fatty liver disease (NAFLD), but whether they have roles beyond the activation of hepatic stellate cells remains unexplored. We investigated the succinate/SUCNR1 axis in the context of NAFLD specifically in hepatocytes.We studied the phenotype of ...
Maria Dolores Frutos, Catalina Nunez-Roa   +1 more
exaly   +4 more sources

Some of the next articles are maybe not open access.

Related searches:

Succinate-SUCNR1 induces renal tubular cell apoptosis

American Journal of Physiology - Cell Physiology, 2023
Succinate has long been known to be only an intermediate product of the tricarboxylic acid cycle until identified as a natural ligand for SUCNR1 in 2004. SUCNR1 is widely expressed throughout the body, especially in the kidney. Abnormally elevated succinate is associated with many diseases, including obesity, type 2 diabetes, nonalcoholic fatty liver ...
Zhijian Huang, Ti Zhou, Weiwei Qi
exaly   +3 more sources

Insight into SUCNR1 (GPR91) structure and function [PDF]

Pharmacology & Therapeutics, 2016
SUCNR1 (or GPR91) belongs to the family of G protein-coupled receptors (GPCR), which represents the largest group of membrane proteins in human genome. The majority of marketed drugs targets GPCRs, directly or indirectly. SUCNR1 has been classified as an orphan receptor until a landmark study paired it with succinate, a citric acid cycle intermediate ...
Julien Hanson, Bernard Pirotte, François Jouret   +2 more
exaly   +3 more sources

Protective succinate-SUCNR1 metabolic stress signaling gone bad

Cell Metabolism, 2021
The TCA cycle metabolite succinate functions as an intra- and extracellular signal of metabolic stress. Based on the phenotype of UCP-1-deficient mice, Mills et al. (2021) now report in Nature Metabolism that accumulation of extracellular succinate due to impaired elimination in thermogenic fat drives liver inflammation and fibrosis through the ...
Winther, Sally, Trauelsen, Mette, Schwartz, Thue W.   +2 more
openaire   +3 more sources

234-OR: Succinate Potentiates Insulin Secretion through SUCNR1

Diabetes, 2023
Here, we examined the role of succinate, a metabolite that acts by engaging the succinate receptor 1 (SUCNR1), in regulating insulin secretion by β-cells. We found that glucose increases SUCNR1 expression in β-cells and that activating SUCNR1 with either extracellular succinate or a synthetic agonist boosts glucose-stimulated insulin secretion through ...
JOAN SABADELL-BASALLOTE, BRENNO D. ASTIARRAGA, MIRIAM EJARQUE, MARIA REPOLLÉS-DE-DALMAU, FRANCESC X. SUREDA, DARIO F. DE JESUS, CATALINA NÚÑEZ ROA, ANDREA MARI, ROHIT KULKARNI, JOAN J. VENDRELL, SONIA FERNANDEZ-VELEDO   +10 more
openaire   +1 more source

Succinate Receptors (SUCNR1) as a Potential Target for Pharmacotherapy

Pharmaceutical Chemistry Journal, 2015
A considerable number of reports have been published in recent years on G protein-coupled receptors, their distribution in the body, mechanism of activation, and potential pathways for pharmacological actions. Intermediates in carbohydrate, fat, and protein metabolism and the tricarboxylic acid cycle, operating as endogenous ligands for a large group ...
S. V. Okovityi, S. V. Rad’ko, E. B. Shustov   +2 more
openaire   +1 more source

Succinate Activation of SUCNR1 Predisposes Severely Injured Patients to Neutrophil-mediated ARDS

Annals of Surgery, 2020
Objectives: Identify the metabolites that are increased in the plasma of severely injured patients that developed ARDS versus severely injured patients that did not, and assay if these increased metabolites prime pulmonary sequestration of neutrophils (PMNs) and induce pulmonary sequestration in an animal model of ARDS.
Geoffrey R, Nunns, Navin, Vigneshwar, Marguerite R, Kelher, Gregory R, Stettler, Lajos, Gera, Julie A, Reisz, Angelo, D'Alessandro, Joshua, Ryon, Kirk C, Hansen, Fabia, Gamboni, Ernest E, Moore, Erik D, Peltz, Mitchell J, Cohen, Kenneth L, Jones, Angela, Sauaia, Xiayuan, Liang, Anirban, Banerjee, Arsen, Ghasabyan, James G, Chandler, Sophia, Rodawig, Carter, Jones, Andrew, Eitel, Patrick, Hom, Christopher C, Silliman   +23 more
openaire   +2 more sources

Discovery of a SUCNR1 antagonist for potential treatment of diabetic nephropathy: In silico and in vitro studies

International Journal of Biological Macromolecules
Diabetic nephropathy (DN) is one of the most severe complications of diabetes mellitus. Succinate Receptor 1 (SUCNR1), a member of the G-protein-coupled receptor (GPCR) family, represents a potential target for treatment of DN. Here, utilizing multi-strategy in silico virtual screening methods containing AlphaFold2 modelling, molecular dynamics (MD ...
Xuting, Zhang, Dongxin, Lyu, Shanshan, Li, Haiming, Xiao, Yufan, Qiu, Kangwei, Xu, Nianhang, Chen, Li, Deng, Heqing, Huang, Ruibo, Wu   +9 more
openaire   +2 more sources

The Mechanism of Stimulation of Myogenesis under the Action of Succinic Acid Through the Succinate Receptor SUCNR1

Biohimiâ
In a study on cells of the C2C12 line, the effect of succinic acid on the processes of myogenesis was studied. In the concentration range of 10-1000 microns, succinic acid stimulated the process of myogenic differentiation, increasing the number of myogenesis factors MyoD (at all stages of myogenesis) and myogenin (at the stage of terminal ...
Yuliya V, Abalenikhina, Mariya O, Isayeva, Pavel Yu, Mylnikov, Alexey V, Shchulkin, Elena N, Yakusheva   +4 more
openaire   +2 more sources

Succinate aggravates pulmonary fibrosis through the succinate/SUCNR1 axis.

Mechanisms of lung injury and repair, 2023
Rishi Rajesh, Reham Atallah, Ilse Lanz, Wolfgang Platzer, Stefano Angiari, Leigh Marsh, Thomas Bärnthaler, Akos Heinemann   +7 more
openaire   +1 more source