Genetic, cellular, and environmental factors influencing tumourigenesis in carriers of succinate dehydrogenase germline mutations. [PDF]
Endocr Relat CancerLim ES +4 more
europepmc +1 more source
Metabolic Reprogramming of Macrophages Plays a Dual Role in Periodontitis: From Pathogenesis to Therapy. [PDF]
FASEB JChen T +8 more
europepmc +1 more source
Impact of myeloid-specific Sucnr1 deficiency in mice with diet-induced NASH
, 2023 openaire +1 more source
SUCNR1 Is Expressed in Human Placenta and Mediates Angiogenesis: Significance in Gestational Diabetes [PDF]
International Journal of Molecular Sciences, 2021 Placental hypervascularization has been reported in pregnancy-related pathologies such as gestational diabetes mellitus (GDM). Nevertheless, the underlying causes behind this abnormality are not well understood. In this study, we addressed the expression
Reham Atallah +2 more
exaly +6 more sources
Protective effects of the succinate/SUCNR1 axis on damaged hepatocytes in NAFLD [PDF]
Metabolism: Clinical and Experimental, 2023 [Objective]: Succinate and succinate receptor 1 (SUCNR1) are linked to fibrotic remodeling in models of non-alcoholic fatty liver disease (NAFLD), but whether they have roles beyond the activation of hepatic stellate cells remains unexplored.
Patricia Aspichueta +2 more
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Insight into SUCNR1 (GPR91) structure and function [PDF]
Pharmacology & Therapeutics, 2016 peer reviewedSUCNR1 (or GPR91) belongs to the family of G protein-coupled receptors (GPCR), which represents the largest group of membrane proteins in human genome. The majority of marketed drugs targets GPCRs, directly or indirectly.
Julien Hanson +2 more
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Cell selectivity in succinate receptor SUCNR1/GPR91 signaling in skeletal muscle
American Journal of Physiology - Endocrinology and Metabolism, 2023 Succinate is released by skeletal muscle during exercise and activates SUCNR1/GPR91. Signaling of SUCNR1 is involved in cell-cell communication in skeletal muscle.
Anna Krook +2 more
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Succinate-SUCNR1 induces renal tubular cell apoptosis
American Journal of Physiology - Cell Physiology, 2023Succinate has long been known to be only an intermediate product of the tricarboxylic acid cycle until identified as a natural ligand for SUCNR1 in 2004. SUCNR1 is widely expressed throughout the body, especially in the kidney. Abnormally elevated succinate is associated with many diseases, including obesity, type 2 diabetes, nonalcoholic fatty liver ...
Ti Zhou, Weiwei Qi, Fuyan Hong
exaly +3 more sources
SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression [PDF]
Cell Metabolism, 2023 Adipose tissue modulates energy homeostasis by secreting leptin, but little is known about the factors governing leptin production. We show that succinate, long perceived as a mediator of immune response and lipolysis, controls leptin expression via its ...
Carolina Pimenta-Lopes +2 more
exaly +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2018 Until recently, little is known about whether succinate, a key metabolite in the Krebs cycle and microbial propionate synthesis, has any physiological role in the gut. De Vadder et al.
Peihua Jiang +2 more
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