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234-OR: Succinate Potentiates Insulin Secretion through SUCNR1
Diabetes, 2023Here, we examined the role of succinate, a metabolite that acts by engaging the succinate receptor 1 (SUCNR1), in regulating insulin secretion by β-cells. We found that glucose increases SUCNR1 expression in β-cells and that activating SUCNR1 with either extracellular succinate or a synthetic agonist boosts glucose-stimulated insulin secretion through ...
JOAN SABADELL-BASALLOTE +10 more
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Single nucleotide polymorphism rs13079080 is associated with differential regulation of the succinate receptor 1 (SUCNR1) gene by miRNA-4470 [PDF]
RNA Biology, 2019 Contains fulltext : 208567.pdf (Publisher’s version ) (Open Access)Oxidative stress is a feature of many common diseases. It leads to excessive formation and subsequent release of the mitochondrial metabolite succinate, which acts as a ...
Laura Lorés-Motta +2 more
exaly +3 more sources
Succinate Receptors (SUCNR1) as a Potential Target for Pharmacotherapy
Pharmaceutical Chemistry Journal, 2015A considerable number of reports have been published in recent years on G protein-coupled receptors, their distribution in the body, mechanism of activation, and potential pathways for pharmacological actions. Intermediates in carbohydrate, fat, and protein metabolism and the tricarboxylic acid cycle, operating as endogenous ligands for a large group ...
S. V. Okovityi +2 more
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Succinate Activation of SUCNR1 Predisposes Severely Injured Patients to Neutrophil-mediated ARDS
Annals of Surgery, 2020Objectives: Identify the metabolites that are increased in the plasma of severely injured patients that developed ARDS versus severely injured patients that did not, and assay if these increased metabolites prime pulmonary sequestration of neutrophils (PMNs) and induce pulmonary sequestration in an animal model of ARDS.
Geoffrey R, Nunns +23 more
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Biohimiâ
In a study on cells of the C2C12 line, the effect of succinic acid on the processes of myogenesis was studied. In the concentration range of 10-1000 microns, succinic acid stimulated the process of myogenic differentiation, increasing the number of myogenesis factors MyoD (at all stages of myogenesis) and myogenin (at the stage of terminal ...
Yuliya V, Abalenikhina +4 more
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In a study on cells of the C2C12 line, the effect of succinic acid on the processes of myogenesis was studied. In the concentration range of 10-1000 microns, succinic acid stimulated the process of myogenic differentiation, increasing the number of myogenesis factors MyoD (at all stages of myogenesis) and myogenin (at the stage of terminal ...
Yuliya V, Abalenikhina +4 more
openaire +2 more sources
International Journal of Biological Macromolecules
Diabetic nephropathy (DN) is one of the most severe complications of diabetes mellitus. Succinate Receptor 1 (SUCNR1), a member of the G-protein-coupled receptor (GPCR) family, represents a potential target for treatment of DN. Here, utilizing multi-strategy in silico virtual screening methods containing AlphaFold2 modelling, molecular dynamics (MD ...
Xuting, Zhang +9 more
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Diabetic nephropathy (DN) is one of the most severe complications of diabetes mellitus. Succinate Receptor 1 (SUCNR1), a member of the G-protein-coupled receptor (GPCR) family, represents a potential target for treatment of DN. Here, utilizing multi-strategy in silico virtual screening methods containing AlphaFold2 modelling, molecular dynamics (MD ...
Xuting, Zhang +9 more
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Succinate aggravates pulmonary fibrosis through the succinate/SUCNR1 axis.
Mechanisms of lung injury and repair, 2023Rishi Rajesh +7 more
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Succinate-SUCNR1 signaling drives Treg-mediated suppression in the solid tumor 4795
The Journal of ImmunologyAbstract Description The success of T cell therapies in solid tumors is limited by the immunosuppressive tumor microenvironment (TME). The secretion of metabolites in the TME directs the immune landscape, acting as signaling molecules regulating immune responses and reducing the efficacy of ...
Sinéad Kinsella +7 more
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P-98 SUCNR1/SDHA Profiles as Predictors of HNSCC Prognosis
Oral Oncology, 2021L. Pujol-Vilà +6 more
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Role of succinate/sucnr1 axis in the development of masld-related HCC
Trabajo presentado en el 50º Congreso anual Asociación Española para el Estudio del Hígado, celebrado en Madrid, del 26 al 28 de febrero de ...Salmerón Pelado, Laura +8 more
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