Results 51 to 60 of about 941,649 (339)

Effects of hunger state on flavour pleasantness conditioning at home: flavour-nutrient learning vs. flavour-flavour learning [PDF]

, 2007
This study examined acquired liking of flavour preferences through flavour-flavour and flavour-nutrient learning under hungry or sated conditions in a naturalistic setting.
Ackroff, Ackroff, Ackroff, Alexy, Appleton, Baeyens, Berkey, Birch, Booth, Booth, Booth, Booth, Booth, Booth, Brunstrom, Capaldi, Capaldi, De Houwer, Elizalde, Fedorchak, Gibson, Gibson, Johnson, Kern, Looy, Looy, Lucas, Lucy C. Chambers, Martin R. Yeomans, Meiselman, Mobini, Myers, Myers, Myers, Myers, Richardson, Rogers, Sclafani, Sclafani, Sclafani, Sclafani, Sirous Mobini, Steiner, Stevenson, Stevenson, Stevenson, Tinley, Warwick, Yeomans, Yeomans, Yeomans, Yeomans, Yiin, Zellner, Zellner   +54 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Effect of Oocyte Vitrification Before and After in Vitro Maturation Towards Bcl-2, Bax and Bcl-2/Bax Ratio Expression [PDF]

, 2016
Objectives: to compare the expression of Bcl-2, Bax and Bcl-2/Bax ratio in cumulus cell and oocyte between vitrified oocyte pre and post in vitro maturation.Materials and Methods: Maturation was operated in medium TC 100 µl for 24 hours.
Aswin, H. (Haryanto), Faizah, Z. (Zakiyatul), Lunardhi, H. (Hamdani)   +2 more
core  

Multilocus sequence types of invasive Corynebacterium diphtheriae isolated in the Rio de Janeiro urban area, Brazil [PDF]

, 2012
Invasive infections caused by Corynebacterium diphtheriae in vaccinated and non-vaccinated individuals have been reported increasingly. In this study we used multilocus sequence typing (MLST) to study genetic relationships between six invasive strains of
Azevedo, V., Baldwin, Adam, Bolt, F., Dowson, Christopher G., Guiso, N., Hirata, R., Mattos-Guaraldi, A. L., Miyoshi, A., Pacheco, L. G. C., Rosso, M. L., Santos, L. S., Soares, S. C., Viguetti, S. Z.   +12 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Optimization of osmotic dehydration of tomatoes slices in salt and sucrose solutions using response surface methodology

Revue des Énergies Renouvelables, 2015
Response Surface Methodology (RSM) was used to investigate the effect of temperature solution, immersion time, salt concentration and sucrose concentration on the water loss and solid gain during osmotic dehydration of tomatoes slices.
A. Ferradji, F.S. Aït Chaouche, D. Belhachat, A. Malek   +3 more
doaj  

Biogenesis of Glyoxysomes [PDF]

, 1980
Biosynthesis of isocitrate lyase, a tetrameric enzyme of the glyoxysomal matrix, was studied in Neurospora crassa, in which the formation of glyoxysomes was induced by a substitution of sucrose medium by acetate medium. * 1.
Neupert, Walter, Zimmermann, Richard
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

MaB-flocs for a more sustainable wastewater treatment [PDF]

, 2010
Conventional wastewater treatment with activated sludge has a large carbon footprint, high aeration rates are combined with CO2 emission from bacteria. By using micro-algal bacterial flocs (MaB-flocs), CO2 could be captured within the biomass and oxygen
Boon, Nico, Maes, Guy, Van Den Hende, Sofie, Vervaeren, Han   +3 more
core   +1 more source