Results 71 to 80 of about 86,294 (392)

Versatile C(sp2)−C(sp3) ligand couplings of sulfoxides for the enantioselective synthesis of diarylalkanes [PDF]

, 2016
The reaction of chiral (hetero)aryl benzyl sulfoxides with Grignard reagents affords enantiomerically pure diarylalkanes in up to 98% yield and greater than 99.5% enantiomeric excess.
Aggarwal, Andries, Bagutski, Burns, Burns, Capozzi, Carreño, Chausset-Boissarie, Costantino, Crudden, Delouvrié, Eberhart, Eberhart, Eberhart, Evans, Farid, Gianino, Glasspoole, Glasspoole, Han, Hartwig, Hoffmann, Kawai, Khim, Kita, Kopp, Lennox, Li, Liu, Lozada, Matthew, McAllister, McAllister, Melzig, Miller, Moragas, Moriarty, Oae, Oae, Oae, Oae, Oae, Oae, Oae, Oae, Oae, Procopiou, Pummerer, Robak, Rochette, Roe, Roe, Roe, Roesner, Schmidt, Shang, Smith, Smith, Snyder, Solá, Sonawane, Stymiest, Ting, Tohma, Tolstoy, Trost, Trost, Wakabayashi, Watson, Wittig, Yoshida, Zhong, Çalimsiz   +72 more
core   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Molybdatophosphoric acid as an efficient catalyst for the catalytic and chemoselective oxidation of sulfides to sulfoxides using urea hydrogen peroxide as a commercially available oxidant [PDF]

Journal of the Serbian Chemical Society, 2010
An efficient procedure for the chemoselective oxidation of alkyl (aryl) sulfides to the corresponding sulfoxides using urea hydrogen peroxide (UHP) in the presence of a catalytic amount of molybdatophosphoric acid at room temperature is described.
ALIREZA HASANINEJAD, MOHAMMAD ALI ZOLFIGOL, GHOLAMABBAS CHEHARDOLI, MOHAMMAD MOKHLESI   +3 more
doaj  

Chalcogen bond-guided conformational isomerization enables catalytic dynamic kinetic resolution of sulfoxides

Nature Communications, 2022
Conformational isomerization of organic molecules can be guided by noncovalent interactions. Here, the authors report the synthesis of chiral sulfoxides catalyzed by N-heterocyclic carbenes; intramolecular chalcogen bonding interactions are key for ...
Jianjian Liu, Mali Zhou, Rui Deng, Pengcheng Zheng, Yonggui Robin Chi   +4 more
doaj   +1 more source

Inhibition of methionine sulfoxide reduction by dimethyl sulfoxide

BMB Reports, 2009
Dimethyl sulfoxide (DMSO) is widely used in chemistry and biology as a solvent and as a cryoprotectant. It is also used as a pharmaceutical agent for the treatment of interstitial cystitis and rheumatoid arthritis. Previous reports described DMSO as being reduced by methionine-S-sulfoxide reductase (MsrA).
Geun-Hee, Kwak, Seung Hee, Choi, Jae-Ryong, Kim, Hwa-Young, Kim   +3 more
openaire   +3 more sources

Metal-organic frameworks as selective or chiral oxidation catalysts [PDF]

, 2014
Since the discovery of Metal Organic Frameworks (MOFs) in the early 1990s, the amount of new structures has grown exponentially. A MOF typically consists of inorganic nodes that are connected by organic linkers to form crystalline, highly porous ...
Leus, Karen, Liu, Ying-Ya, Van Der Voort, Pascal   +2 more
core   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Benzyl 2,4-dichlorophenyl sulfoxide

Molbank
Benzyl 2,4-dichlorophenyl sulfoxide was synthesized both in racemic and in an enantiopure form. This enantiopure sulfoxide is a further successful confirmation of our straightforward protocol to yield easily chiral aryl benzyl sulfoxides.
Maria Annunziata M. Capozzi, Joan F. Piniella Febrer, Cosimo Cardellicchio   +2 more
doaj   +1 more source

Advancements in Asymmetric Synthesis of Esomeprazole and Chiral Sulfoxide Drugs: A Comprehensive Review and Future Perspectives [PDF]

E3S Web of Conferences
Chiral sulfoxides are widely present in biologically active molecules and pharmaceuticals, and their efficient and green synthesis has been a hot research topic.
Yu Jingwen
doaj   +1 more source