Results 71 to 80 of about 17,306 (293)

Synthesis of cyclic alpha-diazo-beta-keto sulfoxides in batch and continuous flow [PDF]

, 2017
Diazo transfer to beta–keto sulfoxides to form stable isolable alpha-diazo-beta-keto sulfoxides has been achieved for the first time. Both monocyclic and benzofused ketone derived beta-keto sulfoxides were successfully explored as substrates for diazo ...
Buckley, Naomi M., Collins, Stuart G., Eccles, Kevin S., Lawrence, Simon E., Maguire, Anita R., McCaw, Patrick G.   +5 more
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

A note on the effectiveness of selenium supplementation of Irish-grown Allium crops. [PDF]

, 2014
peer-reviewedThis study is funded by the Department of Agriculture and Food through the Network and Team Building Initiative of the Food Institutional Research Measure (FIRM Reference Number 06/NITARFC6).Onions and other Allium crops contain high levels ...
Brunton, Nigel, Finn, Leo, Gaffney, Michael, Rai, Dilip K., Reilly, Kim, Valverde, Juan   +5 more
core  

Spiral Galaxies as Enantiomers: Chirality, an Underlying Feature in Chemistry and Astrophysics

, 2005
Spiral galaxies are axi-symmetric objects showing 2D-chirality when projected onto a plane. Features in common with tetrahedral molecules are pointed out, in particular the existence of a preferred chiral modality for genetic galaxies as in aminoacids ...
Aryal, Aryal, Avalos, Barron, Binney, Binney, Busarello, Capozziello, Capozziello, Capozziello, Capozziello, Eidelman, Eliel, Elmegreen, Elmegreen, Gerin, Hu, Iye, Kashikawa, King, Kondepudi, Liddle, Lin, Lin, Mislow, Peacock, Rayner, Ruch, Sandage, Sparke, Sugai, Vorontsov-Vel'yaminov   +31 more
core   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Versatile C(sp2)−C(sp3) ligand couplings of sulfoxides for the enantioselective synthesis of diarylalkanes [PDF]

, 2016
The reaction of chiral (hetero)aryl benzyl sulfoxides with Grignard reagents affords enantiomerically pure diarylalkanes in up to 98% yield and greater than 99.5% enantiomeric excess.
Aggarwal, Andries, Bagutski, Burns, Burns, Capozzi, Carreño, Chausset-Boissarie, Costantino, Crudden, Delouvrié, Eberhart, Eberhart, Eberhart, Evans, Farid, Gianino, Glasspoole, Glasspoole, Han, Hartwig, Hoffmann, Kawai, Khim, Kita, Kopp, Lennox, Li, Liu, Lozada, Matthew, McAllister, McAllister, Melzig, Miller, Moragas, Moriarty, Oae, Oae, Oae, Oae, Oae, Oae, Oae, Oae, Oae, Procopiou, Pummerer, Robak, Rochette, Roe, Roe, Roe, Roesner, Schmidt, Shang, Smith, Smith, Snyder, Solá, Sonawane, Stymiest, Ting, Tohma, Tolstoy, Trost, Trost, Wakabayashi, Watson, Wittig, Yoshida, Zhong, Çalimsiz   +72 more
core   +2 more sources

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

The influence of reaction conditions on the Diels-Alder cycloadditions of 2-thio-3-chloroacrylamides; investigation of thermal, catalytic and microwave conditions [PDF]

, 2010
The Diels-Alder cycloadditions of cyclopentadiene and 2,3-dimethyl-1,3-butadiene to a range of 2-thio-3-chloroacrylamides under thermal, catalytic and microwave conditions is described.
Chopra, Jay, Kissane, Marie, Lawrence, Simon E., Lynch, Denis, Maguire, Anita R.   +4 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Nanostructures from self-assembling triazine tertiary amine N-oxide amphiphiles [PDF]

, 2013
A new set of amphiphilic tertiary amine N-oxides has been prepared and their self-assembly properties observed in aqueous solution by tensiometry, dynamic and static light scattering.
Adamczyk, Albertorio, Ariga, Aswal, Barberá, Barlow, Baskakov, Baskakov, Baskakov, Bernier, Bolen, Cafferty, Chae, Chae, Chae, Chae, Chae, Chaudier, Cheng, Dabkowski, De, De Bernardez Clark, Diaz-Ortiz, Dilly, Goracci, Harries, Herrmann, Jorgensen, Kakehashi, Kameta, Kane, Kawasaki, Kawasaki, Kawasaki, Kawasaki, Kimizuka, Koopman, Kuwamura, Lair, Lewinska, Ma, Macdonald, Maeda, Maly, Marsh, Marsh, McQuade, Middelberg, Moore, Muraoka, Murray, Nowick, O’Neil, O’Neil, Rasmussen, Rasmussen, Rathman, Rosenbaum, Sagle, Simanek, Singh, Singh, Stanczak, Tao, Thorsteinsson, Vincentelli, Vuillard, Vuillard, Wang, Wuest, Yancey, Yu, Zhang, Zhang   +73 more
core   +1 more source