Host SUMOylation in bacterial infections and immune defense mechanisms [PDF]
Frontiers in MicrobiologySUMOylation, the covalent attachment of small ubiquitin-like modifier proteins (SUMO) to lysine residues of target substrates, has emerged as a crucial post-translational modification regulating various cellular processes.
Yuhua Xu +11 more
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SUMOylation of the lysine-less tumor suppressor p14ARF counters ubiquitylation-dependent degradation [PDF]
Cell Death and Diseasep14ARF is a lysine-less tumor suppressor that enhances SUMOylation of its interactors. Although p14ARF is known to interact with the E2 SUMO conjugating enzyme UBC9, the link between ARF and SUMOylation is poorly understood and the potential impact of ...
Ahmed El Motiam +17 more
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APP SUMOylation prevents BACE1 cleavage of APP and increases BACE1 degradation to promote the nonamyloidogenic pathway [PDF]
Molecular MedicineAmyloid precursor protein (APP) plays a key role in the pathogenesis of Alzheimer’s disease (AD). APP undergoes different posttranslational modifications, but the role of SUMOylation modification of APP in the pathogenesis of AD is not known.
Yen-Chen Liu +5 more
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Human polycomb 2 protein is a SUMO E3 ligase and alleviates substrate-induced inhibition of cystathionine beta-synthase sumoylation. [PDF]
PLoS ONE, 2008 Human cystathionine beta-synthase (CBS) catalyzes the first irreversible step in the transsulfuration pathway and commits homocysteine to the synthesis of cysteine. Mutations in CBS are the most common cause of severe hereditary hyperhomocysteinemia.
Nitish Agrawal, Ruma Banerjee
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RECENT ADVANCES IN POST-TRANSLATIONAL REGULATION OF PLANT DEFENSE RESPONSES BEYOND PHOSPHORYLATION [PDF]
Journal of Plant Development, 2021 During plant-microbe interactions, plant immune signaling relies significantly on post-translational modifications (PTMs) to induce rapid downstream changes.
Tim XING, Ziwei GUO
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Frontiers in Immunology, 2021 Conjugation with the small ubiquitin-like modifier (SUMO) constitutes a key post-translational modification regulating the stability, activity, and subcellular localization of its target proteins.
Jörn Karhausen +3 more
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Frontiers in Cellular and Infection Microbiology, 2022 SUMOylation is one of the post-translational modifications that have recently been described as a key regulator of various cellular, nuclear, metabolic, and immunological processes.
Jhalak Singhal +11 more
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Sumoylation of Hes6 Regulates Protein Degradation and Hes1-Mediated Transcription [PDF]
Endocrinology and Metabolism, 2015 BackgroundHes6 is a transcriptional regulator that induces transcriptional activation by binding to transcription repressor Hes1 and suppressing its activity. Hes6 is controlled by the ubiquitin-proteosome-mediated degradation system.
Jiwon Lee +3 more
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Phosphorylation of Ubc9 by Cdk1 enhances SUMOylation activity. [PDF]
PLoS ONE, 2012 Increasing evidence has pointed to an important role of SUMOylation in cell cycle regulation, especially for M phase. In the current studies, we have obtained evidence through in vitro studies that the master M phase regulator CDK1/cyclin B kinase ...
Yee-Fun Su +4 more
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Analysis of human cytomegalovirus-encoded SUMO targets and temporal regulation of SUMOylation of the immediate-early proteins IE1 and IE2 during infection. [PDF]
PLoS ONE, 2014 Post-translational modification of proteins by members of the small ubiquitin-like modifier (SUMO) is involved in diverse cellular functions. Many viral proteins are SUMO targets and also interact with the cellular SUMOylation system.
Eui Tae Kim +5 more
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