Results 11 to 20 of about 32,358 (200)
SUMOylation pathway alteration coupled with downregulation of SUMO E2 enzyme at mucosal epithelium modulates inflammation in inflammatory bowel disease [PDF]
Open Biology, 2017 Post-translational modification pathways such as SUMOylation are integral to all cellular processes and tissue homeostasis. We investigated the possible involvement of SUMOylation in the epithelial signalling in Crohn's disease (CD) and ulcerative ...
Salman Ahmad Mustfa +11 more
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Frontiers in Cell and Developmental Biology, 2021 Protein sumoylation is one of the most important post-translational modifications regulating many biological processes (Flotho A & Melchior F. 2013. Ann Rev. Biochem. 82:357–85).
Qian Nie +21 more
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Sumoylation at the Host-Pathogen Interface
Biomolecules, 2012 Many viral proteins have been shown to be sumoylated with corresponding regulatory effects on their protein function, indicating that this host cell modification process is widely exploited by viral pathogens to control viral activity.
Van G. Wilson
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Frontiers in Cell and Developmental Biology, 2023 Background: Recent studies have revealed that SUMOylation modifications are involved in various biological processes, including cancer development and progression.
Zhike Chen +18 more
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The Role of Sumoylation in the Response to Hypoxia: An Overview
Cells, 2020 Sumoylation is the covalent attachment of the small ubiquitin-related modifier (SUMO) to a vast variety of proteins in order to modulate their function. Sumoylation has emerged as an important modification with a regulatory role in the cellular response ...
Chrysa Filippopoulou +2 more
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Natural Products Against Renal Fibrosis via Modulation of SUMOylation
Frontiers in Pharmacology, 2022 Renal fibrosis is the common and final pathological process of kidney diseases. As a dynamic and reversible post-translational modification, SUMOylation and deSUMOylation of transcriptional factors and key mediators significantly affect the development ...
Peng Liu +5 more
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SUMOylation modification-mediated cell death
Open Biology, 2021 SUMOylation dynamically conjugates SUMO molecules to the lysine residue of a substrate protein, which depends on the physiological state of the cell and the attached SUMO isoforms.
Zenghua Sheng +4 more
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SUMOylation represses Nanog expression via modulating transcription factors Oct4 and Sox2. [PDF]
PLoS ONE, 2012 Nanog is a pivotal transcription factor in embryonic stem (ES) cells and is essential for maintaining the pluripotency and self-renewal of ES cells. SUMOylation has been proved to regulate several stem cell markers' function, such as Oct4 and Sox2. Nanog
Yongyan Wu +10 more
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Sumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeast. [PDF]
PLoS ONE, 2009 Tec1 is a transcription factor in the yeast mitogen-activated protein kinase (MAPK) pathway that controls invasive growth. Previously we reported that a fraction of Tec1 protein is sumoylated on residue lysine 54 in normally growing cells.
Yuqi Wang +3 more
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Is Transthyretin a Regulator of Ubc9 SUMOylation? [PDF]
PLoS ONE, 2016 Ageing and mutations of transthyretin (TTR), the thyroid hormones and retinol transporting protein lead to amyloidosis by destabilizing the structure of TTR.
Elżbieta Wieczorek +6 more
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