Results 11 to 20 of about 53,155 (238)

A Chemical and Enzymatic Approach to Study Site-Specific Sumoylation. [PDF]

PLoS ONE, 2015
A variety of cellular pathways are regulated by protein modifications with ubiquitin-family proteins. SUMO, the Small Ubiquitin-like MOdifier, is covalently attached to lysine on target proteins via a cascade reaction catalyzed by E1, E2, and E3 enzymes.
Claudio P Albuquerque, Eyan Yeung, Shawn Ma, Ting Fu, Kevin D Corbett, Huilin Zhou   +5 more
doaj   +13 more sources

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science
A balanced SUMOylation equilibrium safeguards the functional anti‐tumor immune response. Oncogene activation drives SUMOylation, rendering aberrant SUMOylation a hallmark of cancer.
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
doaj   +2 more sources

SUMOylation inhibits FOXM1 activity and delays mitotic transition [PDF]

, 2014
The forkhead box transcription factor FOXM1 is an essential effector of G2/M-phase transition, mitosis and the DNA damage response. As such, it is frequently deregulated during tumorigenesis. Here we report that FOXM1 is dynamically modified by SUMO1 but
Brosens, Jan J., Coombes, R. C., Dunsby, C. W., French, P. M., Gomes, Ana R., Karunarathna, U., Kelly, D. J., Khongkow, P., Kongsema, M., Lam, Eric W.-F., Langer, J. K., Man, Cornelia W-Y., Myatt, Stephen S., Zona, Stefania   +13 more
core   +1 more source

RanBP2-Mediated SUMOylation Promotes Human DNA Polymerase Lambda Nuclear Localization and DNA Repair [PDF]

, 2020
Cellular DNA is under constant attack by a wide variety of agents, both endogenous and exogenous. To counteract DNA damage, human cells have a large collection of DNA repair factors. Among them, DNA polymerase lambda (Polλ) stands out for its versatility,
Cortés Ledesma, Felipe, García Domínguez, Mario, Herrero Ruiz, Andrés M., Moreno Oñate, Marta, Ruiz Pérez, José Francisco   +4 more
core   +1 more source

Sumoylation at the Host-Pathogen Interface

Biomolecules, 2012
Many viral proteins have been shown to be sumoylated with corresponding regulatory effects on their protein function, indicating that this host cell modification process is widely exploited by viral pathogens to control viral activity.
Van G. Wilson
doaj   +1 more source

The Role of Sumoylation in the Response to Hypoxia: An Overview

Cells, 2020
Sumoylation is the covalent attachment of the small ubiquitin-related modifier (SUMO) to a vast variety of proteins in order to modulate their function. Sumoylation has emerged as an important modification with a regulatory role in the cellular response ...
Chrysa Filippopoulou, George Simos, Georgia Chachami   +2 more
doaj   +1 more source

The role of Schizosaccharomyces pombe SUMO ligases in genome stability [PDF]

, 2007
SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that understanding the mechanisms that regulate the process is ...
A. Skilton, al-Khodairy, Allshire, Allshire, Andrews, Apionishev, Branzei, Chakrabarti, Cheng, E.A. Outwin, Ekwall, F.-X. Ogi, F.Z. Watts, Grishchuk, Ho, Ho, Hoege, Hooker, J.C.-Y. Ho, Johnson, Kagey, Kahyo, L. Gardner, L.K. Boyd, M.A.M. Trickey, McDonald, Okubo, Pichler, Potts, Reindle, Sachdev, Schmidt, Sergeant, Shayeghi, Shin, Stelter, Strahl-Bolsinger, Tanaka, Taylor, Thon, Watts, Xhemalce, Xhemalce, Zhao, Zhao   +44 more
core   +2 more sources

Natural Products Against Renal Fibrosis via Modulation of SUMOylation

Frontiers in Pharmacology, 2022
Renal fibrosis is the common and final pathological process of kidney diseases. As a dynamic and reversible post-translational modification, SUMOylation and deSUMOylation of transcriptional factors and key mediators significantly affect the development ...
Peng Liu, Jing Zhang, Yun Wang, Chen Wang, Xinping Qiu, Dan-Qian Chen   +5 more
doaj   +1 more source

SUMOylation patterns and signature characterize the tumor microenvironment and predict prognosis in lung adenocarcinoma

Frontiers in Cell and Developmental Biology, 2023
Background: Recent studies have revealed that SUMOylation modifications are involved in various biological processes, including cancer development and progression.
Zhike Chen, Zhike Chen, Jian Yang, Jian Yang, Lijuan Tang, Lijuan Tang, Xue Sun, Yu Li, Yu Li, Ziqing Sheng, Ziqing Sheng, Hao Ding, Hao Ding, Chun Xu, Chun Xu, Xin Tong, Xin Tong, Jun Zhao, Jun Zhao   +18 more
doaj   +1 more source

SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication. [PDF]

, 2016
Accumulating evidence suggests that viruses hijack cellular proteins to circumvent the host immune system. Ubiquitination and SUMOylation are extensively studied posttranslational modifications (PTMs) that play critical roles in diverse biological ...
Gong, P, Hu, Q, Ke, X, Liu, Y, Meng, J, Shu, B, Wang, H, Zhang, Y, Zheng, C, Zheng, Z   +9 more
core   +1 more source