Results 11 to 20 of about 37,758 (275)
Solo or in Concert: SUMOylation in Pathogenic Fungi [PDF]
The Plant Pathology JournalSUMOylation plays a pivotal role in DNA replication and repair, transcriptional stability, and stress response. Although SUMOylation is a conserved post-translational modification (PTM) in eukaryotes, the number, type, and function of SUMOylation ...
You-Jin Lim, Yong-Hwan Lee
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Recent advances in proteomic workflows to interrogate the SUMOylome in plants [PDF]
New Phytologist, Volume 247, Issue 1, Page 90-96, July 2025.Summary Protein posttranslational modifications (PTMs) are vital for regulating protein functions. SUMOylation, a PTM essential for plant survival, involves attaching a Small Ubiquitin‐like MOdifier (SUMO) to lysine residues of target proteins. SUMOylation influences stress tolerance, cell proliferation, protein stability, and gene expression.
Kishor D. Ingole +3 more
wiley +2 more sources
New insights into SUMOylation and NEDDylation in fibrosis [PDF]
Frontiers in PharmacologyFibrosis is the outcome of any abnormal tissue repair process that results in normal tissue replacement with scar tissue, leading to persistent tissue damage and cellular injury. During the process of fibrosis, many cytokines and chemokines are involved,
Jin Han +13 more
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Regulation of Smoothened Trafficking and Abundance in Hedgehog Signaling
Frontiers in Cell and Developmental Biology, 2022 The GPCR-family protein Smoothened (Smo) is essential for Hedgehog (Hh) signal transduction in both insects and vertebrates. The regulation of subcellular localization and abundance of Smo is a critical step in Hh signaling.
Jianhang Jia, Jin Jiang
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Theranostics, 2023 Rationale: SUMOylation regulates a plethora of biological processes, and its inhibitors are currently under investigation in clinical trials as anticancer agents.
Fang-Lin Zhang +11 more
semanticscholar +1 more source
The emerging roles of SUMOylation in the tumor microenvironment and therapeutic implications
Experimental Hematology & Oncology, 2023 Tumor initiation, progression, and response to therapies depend to a great extent on interactions between malignant cells and the tumor microenvironment (TME), which denotes the cancerous/non-cancerous cells, cytokines, chemokines, and various other ...
Yunru Gu +8 more
semanticscholar +1 more source
SUMOylation in Viral Replication and Antiviral Defense
Advancement of science, 2022 SUMOylation is a ubiquitination‐like post‐translational modification that plays an essential role in the regulation of protein function. Recent studies have shown that proteins from both RNA and DNA virus families can be modified by SUMO conjugation ...
Yao-min Fan +10 more
semanticscholar +1 more source
eLife, 2021 The post-translational modification of histones by the small ubiquitin-like modifier (SUMO) protein has been associated with gene regulation, centromeric localization, and double-strand break repair in eukaryotes.
Calvin Jon A Leonen +12 more
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Nucleic Acids Research, 2021 N 6-Methyladenosine (m6A) is the most abundant modification within diverse RNAs including mRNAs and lncRNAs and is regulated by a reversible process with important biological functions.
Guofang Hou +10 more
semanticscholar +1 more source
Nature Communications, 2022 In addition to investigating the virology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), discovering the host–virus dependencies are essential to identify and design effective antiviral therapy strategy.
Shouheng Jin +18 more
semanticscholar +1 more source