Results 21 to 30 of about 37,758 (275)

FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance Angiogenesis, the formation of new blood vessels, contributes fundamentally to embryonic development, tissue homeostasis, and wound healing.
Xiaolong Zhu, Cong Qiu, Yiran Wang, Yuanqing Jiang, Yefeng Chen, Linge Fan, R. Ren, Yunyun Wang, Yu Chen, Yanzhi Feng, Xiaofei Zhou, Yunhui Zhu, Zhen Ge, Dongwu Lai, Lingfeng Qin, M. Simons, Luyang Yu   +16 more
semanticscholar   +1 more source

Activated SUMOylation restricts MHC class I antigen presentation to confer immune evasion in cancer

Journal of Clinical Investigation, 2022
Activated SUMOylation is a hallmark of cancer. Starting from a targeted screening for SUMO-regulated immune evasion mechanisms, we identified an evolutionarily conserved function of activated SUMOylation, which attenuated the immunogenicity of tumor ...
U. Demel, Marlitt Böger, S. Yousefian, C. Grunert, Le Zhang, P. Hotz, A. Gottschlich, Hazal Köse, Konstandina Isaakidis, Dominik Vonficht, F. Grünschläger, Elena Rohleder, K. Wagner, Judith Dönig, V. Igl, B. Brzezicha, F. Baumgartner, Stefan Habringer, Jens Löber, B. Chapuy, Carl Weidinger, S. Kobold, S. Haas, A. Busse, S. Müller, Matthias Wirth, M. Schick, U. Keller   +27 more
semanticscholar   +1 more source

The E3 Ligase PIAS1 Regulates p53 Sumoylation to Control Stress-Induced Apoptosis of Lens Epithelial Cells Through the Proapoptotic Regulator Bax

Frontiers in Cell and Developmental Biology, 2021
Protein sumoylation is one of the most important post-translational modifications regulating many biological processes (Flotho A & Melchior F. 2013. Ann Rev. Biochem. 82:357–85).
Qian Nie, Huimin Chen, Ming Zou, Ling Wang, Min Hou, Jia-Wen Xiang, Zhongwen Luo, Xiao-Dong Gong, Jia-Ling Fu, Yan Wang, Shu-Yu Zheng, Yuan Xiao, Yu-Wen Gan, Qian Gao, Yue-Yue Bai, Jing-Miao Wang, Lan Zhang, Xiang-Cheng Tang, Xuebin Hu, Lili Gong, Yizhi Liu, David Wan-Cheng Li   +21 more
doaj   +1 more source

Fatty acids produced by the gut microbiota dampen host inflammatory responses by modulating intestinal SUMOylation

bioRxiv, 2022
The gut microbiota produces a wide variety of metabolites, which interact with intestinal cells and contribute to host physiology. These metabolites regulate intestinal cell activities by modulating either gene transcription or post-translational ...
Chaima Ezzine, Léa Loison, C. Bôle-Feysot, P. Déchelotte, M. Coëffier, D. Ribet   +5 more
semanticscholar   +1 more source

HIV-1 and SUMOylation [PDF]

Retrovirology, 2013
Background The HIV virus hijacks cellular machineries to replicate. Post-translational modifications, like acetylation, phosphorylation or ubiquitination, are no exception. We are interested in studying the interplay between HIV and the SUMOylation pathway.
Beauclair, Guillaume, Saïb, Ali, Zamborlini, Alessia   +2 more
openaire   +3 more sources

SUMOylation pathway alteration coupled with downregulation of SUMO E2 enzyme at mucosal epithelium modulates inflammation in inflammatory bowel disease [PDF]

Open Biology, 2017
Post-translational modification pathways such as SUMOylation are integral to all cellular processes and tissue homeostasis. We investigated the possible involvement of SUMOylation in the epithelial signalling in Crohn's disease (CD) and ulcerative ...
Salman Ahmad Mustfa, Mukesh Singh, Aamir Suhail, Gayatree Mohapatra, Smriti Verma, Debangana Chakravorty, Sarika Rana, Ritika Rampal, Atika Dhar, Sudipto Saha, Vineet Ahuja, C. V. Srikanth   +11 more
doaj   +1 more source

SUMOylation controls the binding of hexokinase 2 to mitochondria and protects against prostate cancer tumorigenesis

Nature Communications, 2021
Human hexokinase 2 is an essential regulator of glycolysis that couples metabolic and proliferative activities in cancer cells. The binding of hexokinase 2 to the outer membrane of mitochondria is critical for its oncogenic activity.
Xun Shangguan, Jianli He, Zehua Ma, Weiwei Zhang, Yiyi Ji, Kai Shen, Zhiying Yue, Wenyu Li, Z. Xin, Quan Zheng, Ying Cao, Jiahua Pan, B. Dong, Jinke Cheng, Qi Wang, W. Xue   +15 more
semanticscholar   +1 more source

SUMOylation Connects Cell Stress Responses and Inflammatory Control: Lessons From the Gut as a Model Organ

Frontiers in Immunology, 2021
Conjugation with the small ubiquitin-like modifier (SUMO) constitutes a key post-translational modification regulating the stability, activity, and subcellular localization of its target proteins.
Jörn Karhausen, Jörn Karhausen, Luis Ulloa, Wei Yang   +3 more
doaj   +1 more source

KRAS mutant–driven SUMOylation controls extracellular vesicle transmission to trigger lymphangiogenesis in pancreatic cancer

Journal of Clinical Investigation, 2022
Lymph node (LN) metastasis occurs frequently in pancreatic ductal adenocarcinoma (PDAC) and predicts poor prognosis for patients. The KRASG12D mutation confers an aggressive PDAC phenotype that is susceptible to lymphatic dissemination.
Yuming Luo, Zhihua Li, Yao Kong, Wang He, Hanhao Zheng, M. An, Yan Lin, Dingwen Zhang, Jiabin Yang, Yue Zhao, Changhao Chen, Rufu Chen   +11 more
semanticscholar   +1 more source

SUMOylation and de‐SUMOylation in response to DNA damage [PDF]

FEBS Letters, 2011
To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin‐like modifier) can regulate protein stability, protein cellular location, and protein–protein interactions.
Chao Huang, Edward T.H. Yeh, Edward T.H. Yeh, Hong Dou, Thang Van Nguyen, Long Sheng Lu   +5 more
openaire   +3 more sources