Results 21 to 30 of about 31,613 (261)

SUMOylation pathway alteration coupled with downregulation of SUMO E2 enzyme at mucosal epithelium modulates inflammation in inflammatory bowel disease [PDF]

Open Biology, 2017
Post-translational modification pathways such as SUMOylation are integral to all cellular processes and tissue homeostasis. We investigated the possible involvement of SUMOylation in the epithelial signalling in Crohn's disease (CD) and ulcerative ...
Salman Ahmad Mustfa, Mukesh Singh, Aamir Suhail, Gayatree Mohapatra, Smriti Verma, Debangana Chakravorty, Sarika Rana, Ritika Rampal, Atika Dhar, Sudipto Saha, Vineet Ahuja, C. V. Srikanth   +11 more
doaj   +1 more source

SUMOylation in Drosophila Development [PDF]

Biomolecules, 2012
Small ubiquitin-related modifier (SUMO), an ~90 amino acid ubiquitin-like protein, is highly conserved throughout the eukaryotic domain. Like ubiquitin, SUMO is covalently attached to lysine side chains in a large number of target proteins. In contrast to ubiquitin, SUMO does not have a direct role in targeting proteins for proteasomal degradation ...
Smith, Matthew, Turki-Judeh, Wiam, Courey, Albert J   +2 more
openaire   +6 more sources

Sumoylation at the Host-Pathogen Interface

Biomolecules, 2012
Many viral proteins have been shown to be sumoylated with corresponding regulatory effects on their protein function, indicating that this host cell modification process is widely exploited by viral pathogens to control viral activity.
Van G. Wilson
doaj   +1 more source

Natural Products Against Renal Fibrosis via Modulation of SUMOylation

Frontiers in Pharmacology, 2022
Renal fibrosis is the common and final pathological process of kidney diseases. As a dynamic and reversible post-translational modification, SUMOylation and deSUMOylation of transcriptional factors and key mediators significantly affect the development ...
Peng Liu, Jing Zhang, Yun Wang, Chen Wang, Xinping Qiu, Dan-Qian Chen   +5 more
doaj   +1 more source

SUMOylation patterns and signature characterize the tumor microenvironment and predict prognosis in lung adenocarcinoma

Frontiers in Cell and Developmental Biology, 2023
Background: Recent studies have revealed that SUMOylation modifications are involved in various biological processes, including cancer development and progression.
Zhike Chen, Zhike Chen, Jian Yang, Jian Yang, Lijuan Tang, Lijuan Tang, Xue Sun, Yu Li, Yu Li, Ziqing Sheng, Ziqing Sheng, Hao Ding, Hao Ding, Chun Xu, Chun Xu, Xin Tong, Xin Tong, Jun Zhao, Jun Zhao   +18 more
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SUMOylation modification-mediated cell death

Open Biology, 2021
SUMOylation dynamically conjugates SUMO molecules to the lysine residue of a substrate protein, which depends on the physiological state of the cell and the attached SUMO isoforms.
Zenghua Sheng, Jing Zhu, Ya-nan Deng, Shan Gao, Shufang Liang   +4 more
doaj   +1 more source

SUMOylation of nuclear actin [PDF]

Journal of Cell Biology, 2009
Actin, a major component of the cytoplasm, is also abundant in the nucleus. Nuclear actin is involved in a variety of nuclear processes including transcription, chromatin remodeling, and intranuclear transport. Nevertheless, the regulation of nuclear actin by posttranslational modifications has not been investigated.
Wilma A. Hofmann, Wilma A. Hofmann, James L. Lessard, Samantha M. Nicol, Primal de Lanerolle, Alessandro Arduini, Frances V. Fuller-Pace, Carlos J. Camacho   +7 more
openaire   +4 more sources

Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation [PDF]

Nucleic Acids Research, 2007
Constitutive and induced protein SUMOylation is involved in the regulation of a variety of cellular processes, such as regulation of gene expression and protein transport, and proceeds mainly in the nucleus of the cell. So far, several hundred SUMOylation targets have been identified, but presumably they represent only a part of the total of proteins ...
Rainer Niedenthal, Bernhard Korn, Matthias Gaestel, Astrid Jakobs, Martin Funk, Fabian Himstedt   +5 more
openaire   +3 more sources

SUMOylation represses Nanog expression via modulating transcription factors Oct4 and Sox2. [PDF]

PLoS ONE, 2012
Nanog is a pivotal transcription factor in embryonic stem (ES) cells and is essential for maintaining the pluripotency and self-renewal of ES cells. SUMOylation has been proved to regulate several stem cell markers' function, such as Oct4 and Sox2. Nanog
Yongyan Wu, Zekun Guo, Haibo Wu, Xiaohai Wang, Lixia Yang, Xiaoyan Shi, Juan Du, Bo Tang, Wenzhong Li, Liping Yang, Yong Zhang   +10 more
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Correlationship between total proteins SUMOylation and papillary thyroid carcinoma in males [PDF]

Waike lilun yu shijian
Objective To investigate the relationship between protein SUMOylation level and the prognosis of papillary thyroid carcinoma(PTC) in males. Methods Protein SUMOylation levels in PTC was analyzed by bioinformatics based on GTEx and TCGA databases and ...
WU Qiao, LIU Wei, ZHENG Jiaojiao, WANG Cong, AI Zhilong
doaj   +1 more source