Results 21 to 30 of about 32,358 (200)

Host SUMOylation in bacterial infections and immune defense mechanisms

Frontiers in Microbiology
SUMOylation, the covalent attachment of small ubiquitin-like modifier proteins (SUMO) to lysine residues of target substrates, has emerged as a crucial post-translational modification regulating various cellular processes.
Yuhua Xu, Xi Ma, Zhifeng Wu, Ruitong Huang, Chenhua Liao, Di Huang, Yujun Tang, Chengbin Zhu, Yaqi Wang, Siyuan Zhang, Peng Liu, Jiaofeng Peng   +11 more
doaj   +1 more source

Perturbation of maternal PIASy abundance disrupts zygotic genome activation and embryonic development via SUMOylation pathway

Biology Open, 2019
During the maternal-to-zygotic transition (MZT), mRNAs and proteins stored in oocytes are degraded and zygotic genes are activated. We have previously shown that the ubiquitin-proteasome system (UPS)-mediated degradation of maternal proteins plays a role
Chika Higuchi, Mari Yamamoto, Seung-Wook Shin, Kei Miyamoto, Kazuya Matsumoto   +4 more
doaj   +1 more source

Protein SUMOylation modification and its associations with disease [PDF]

Open Biology, 2017
SUMOylation, as a post-translational modification, plays essential roles in various biological functions including cell growth, migration, cellular responses to stress and tumorigenesis.
Yanfang Yang, Yu He, Xixi Wang, Ziwei liang, Gu He, Peng Zhang, Hongxia Zhu, Ningzhi Xu, Shufang Liang   +8 more
doaj   +1 more source

A gene-expression screen identifies a non-toxic sumoylation inhibitor that mimics SUMO-less human LRH-1 in liver

eLife, 2015
SUMO-modification of nuclear proteins has profound effects on gene expression. However, non-toxic chemical tools that modulate sumoylation in cells are lacking. Here, to identify small molecule sumoylation inhibitors we developed a cell-based screen that
Miyuki Suzawa, Diego A Miranda, Karmela A Ramos, Kenny K-H Ang, Emily J Faivre, Christopher G Wilson, Laura Caboni, Michelle R Arkin, Yeong-Sang Kim, Robert J Fletterick, Aaron Diaz, John S Schneekloth Jr, Holly A Ingraham   +12 more
doaj   +1 more source

Dynamic sumoylation of promoter-bound general transcription factors facilitates transcription by RNA polymerase II.

PLoS Genetics, 2021
Transcription-related proteins are frequently identified as targets of sumoylation, including multiple subunits of the RNA polymerase II (RNAPII) general transcription factors (GTFs).
Mohammad S Baig, Yimo Dou, Benjamin G Bergey, Russell Bahar, Justin M Burgener, Marjan Moallem, James B McNeil, Akhi Akhter, Giovanni L Burke, Veroni S Sri Theivakadadcham, Patricia Richard, Damien D'Amours, Emanuel Rosonina   +12 more
doaj   +1 more source

SUMOylation and NEDDylation in kidney diseases

Experimental and Molecular Pathology
Kidney disease poses a serious threat to human health and life, while the lack of specific therapeutic targets hinders the treatment of kidney disease.
Zi-Han Chen, Dan Li, Jian-Yu Zhang, Bo-Yu Wei, Hai-Ling Zhao, Ping Li, Dan-Qian Chen   +6 more
doaj   +1 more source

Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target

Frontiers in Molecular Neuroscience, 2019
Glutamate transporter-1 (GLT-1) is a Na+-dependent transporter that plays a key role in glutamate homeostasis by removing excess glutamate in the central nervous system (CNS).
Allison R. Peterson, Devin K. Binder
doaj   +1 more source

mRNA expression analysis of the SUMO pathway genes in the adult mouse retina

Biology Open, 2015
Sumoylation is a reversible post-translational modification that regulates different cellular processes by conjugation/deconjugation of SUMO moieties to target proteins.
Víctor Abad-Morales, Elena B. Domènech, Alejandro Garanto, Gemma Marfany   +3 more
doaj   +1 more source

NF-κB repression by PIAS3 mediated RelA SUMOylation. [PDF]

PLoS ONE, 2012
Negative regulation of the NF-κB transcription factor is essential for tissue homeostasis in response to stress and inflammation. NF-κB activity is regulated by a variety of biochemical mechanisms including phosphorylation, acetylation, and ...
Yuangang Liu, Rebecca Bridges, Aaron Wortham, Molly Kulesz-Martin   +3 more
doaj   +1 more source

Forkhead box protein A2 (FOXA2) protein stability and activity are regulated by sumoylation. [PDF]

PLoS ONE, 2012
The forkhead box protein A2 (FOXA2) is an important regulator of glucose and lipid metabolism and organismal energy balance. Little is known about how FOXA2 protein expression and activity are regulated by post-translational modifications.
Narasimhaswamy S Belaguli, Mao Zhang, F Charles Brunicardi, David H Berger   +3 more
doaj   +1 more source