Results 51 to 60 of about 37,758 (275)
Frontiers in Cell and Developmental Biology, 2023 Background: Recent studies have revealed that SUMOylation modifications are involved in various biological processes, including cancer development and progression.
Zhike Chen +18 more
doaj +1 more source
Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation [PDF]
Nucleic Acids Research, 2007 Constitutive and induced protein SUMOylation is involved in the regulation of a variety of cellular processes, such as regulation of gene expression and protein transport, and proceeds mainly in the nucleus of the cell. So far, several hundred SUMOylation targets have been identified, but presumably they represent only a part of the total of proteins ...
Rainer Niedenthal +5 more
openaire +3 more sources
Biology Open, 2019 During the maternal-to-zygotic transition (MZT), mRNAs and proteins stored in oocytes are degraded and zygotic genes are activated. We have previously shown that the ubiquitin-proteasome system (UPS)-mediated degradation of maternal proteins plays a role
Chika Higuchi +4 more
doaj +1 more source
Sumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeast. [PDF]
PLoS ONE, 2009 Tec1 is a transcription factor in the yeast mitogen-activated protein kinase (MAPK) pathway that controls invasive growth. Previously we reported that a fraction of Tec1 protein is sumoylated on residue lysine 54 in normally growing cells.
Yuqi Wang +3 more
doaj +1 more source
SUMOylation of nuclear actin [PDF]
Journal of Cell Biology, 2009 Actin, a major component of the cytoplasm, is also abundant in the nucleus. Nuclear actin is involved in a variety of nuclear processes including transcription, chromatin remodeling, and intranuclear transport. Nevertheless, the regulation of nuclear actin by posttranslational modifications has not been investigated.
Wilma A. Hofmann +7 more
openaire +4 more sources
Frontiers in Molecular Neuroscience, 2019 Glutamate transporter-1 (GLT-1) is a Na+-dependent transporter that plays a key role in glutamate homeostasis by removing excess glutamate in the central nervous system (CNS).
Allison R. Peterson, Devin K. Binder
doaj +1 more source
mRNA expression analysis of the SUMO pathway genes in the adult mouse retina
Biology Open, 2015 Sumoylation is a reversible post-translational modification that regulates different cellular processes by conjugation/deconjugation of SUMO moieties to target proteins.
Víctor Abad-Morales +3 more
doaj +1 more source
Is Transthyretin a Regulator of Ubc9 SUMOylation? [PDF]
PLoS ONE, 2016 Ageing and mutations of transthyretin (TTR), the thyroid hormones and retinol transporting protein lead to amyloidosis by destabilizing the structure of TTR.
Elżbieta Wieczorek +6 more
doaj +1 more source
International Journal on Biological Sciences, 2021 Rationale: Glioma is the most common primary malignant tumor of human central nervous system, and its rich vascular characteristics make anti-angiogenic therapy become a therapeutic hotspot.
Hao Li +7 more
semanticscholar +1 more source
SUMOylation of claudin-2: SUMOylation of claudin-2 [PDF]
Annals of the New York Academy of Sciences, 2012 The C‐terminal cytoplasmic tails of claudins are likely sites for interaction with proteins that regulate their function. We performed a yeast two‐hybrid screen with the tail of human claudin‐2 against a human kidney cDNA library and identified interactions with the PDZ3 domain of ZO‐2 as well as ubiquitin‐conjugating enzyme E2I (SUMO ligase‐1) and E3 ...
Van Itallie, Christina M. +2 more
openaire +4 more sources