Lack of evidence for superantigen activity of Toxoplasma gondii towards human T cells [PDF]
Brazilian Journal of Medical and Biological Research, 2001 Toxoplasma gondii is an obligatory intracellular parasite whose life cycle may include man as an intermediate host. More than 500 million people are infected with this parasite worldwide. It has been previously reported that T.
A.L. Vallochi +8 more
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Distribution of emm types and superantigens among group A Streptococcus isolates recovered from northern Tshwane, South Africa [PDF]
Southern African Journal of Infectious DiseasesBackground: Group A Streptococcus (GAS) is a human pathogen that causes various diseases ranging from localised infections to toxin- and immune-mediated conditions.
Matete O. Kgasha +5 more
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Abrin Toxin Paradoxically Increases Protein Synthesis in Stimulated CD4+ T-Cells While Decreasing Protein Synthesis in Kidney Cells [PDF]
Current Issues in Molecular BiologyAbrin, a toxin of the rosary pea plant (Abras precatorius), has been implicated as causing an autoimmune demyelinating disease in humans, but the exact mechanisms responsible for the induction of these demyelinating conditions are still unknown.
Bradley Hernlem, Reuven Rasooly
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Proinflammatory synergy between protease and superantigen streptococcal pyogenic exotoxins [PDF]
Infection and ImmunityStreptococcal pyogenic exotoxins (Spe proteins) secreted by Streptococcus pyogenes (group A Streptococcus, GAS) are responsible for scarlet fever and streptococcal toxic shock syndrome.
Anders F. Johnson +5 more
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Evidence that staphylococcal superantigens promote within-patient bacterial persistence following post-operative surgical site infection [PDF]
Infection and ImmunityStaphylococcus aureus is a predominant cause of post-operative surgical site infections and persistent bacteremia. Here, we describe a patient who experienced three episodes of S.
Karine Dufresne +10 more
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Role of Infectious Agents in the Etiology of Kawasaki Disease [PDF]
Pediatric Infectious Disease, 2022 Kawasaki disease (KD) is a multisystemic childhood vasculitis that predominantly affects the coronary arteries. The constellation of clinical features in KD, such as, acute onset of fever, redness of lips and oral mucosa, rash, swelling over palms and ...
Aaqib Banday +2 more
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eLife, 2021 Influenza pandemics pose public health threats annually for lacking vaccine that provides cross-protection against novel and emerging influenza viruses.
Yansheng Li +11 more
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Pathogens, 2022 It has been posited SARS-CoV-2 contains at least one unique superantigen-like motif not found in any other SARS or endemic coronaviruses. Superantigens are potent antigens that can send the immune system into overdrive.
Adam Hamdy, Anthony Leonardi
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Binding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shock. [PDF]
PLoS Biology, 2011 Bacterial superantigens, a diverse family of toxins, induce an inflammatory cytokine storm that can lead to lethal shock. CD28 is a homodimer expressed on T cells that functions as the principal costimulatory ligand in the immune response through an ...
Gila Arad +9 more
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Epidemiology and distribution of 10 superantigens among invasive Streptococcus pyogenes disease in Germany from 2009 to 2014. [PDF]
PLoS ONE, 2017 A nationwide laboratory-based surveillance study of invasive S. pyogenes infections was conducted in Germany. Invasive isolates (n = 719) were obtained between 2009 and 2014. Most isolates were obtained from blood (92.1%).
Matthias Imöhl +3 more
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