Results 21 to 30 of about 21,065 (189)
Endogenous Superantigens Shape Response to Exogenous Superantigens [PDF]
Clinical and Vaccine Immunology, 2005 ABSTRACT Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vβ8 in the periphery. Consequently, the magnitude of immune response to exogenous superantigen staphylococcal enterotoxin B, which activates TCR Vβ8 + T cells, was ...
Govindarajan, Rajagopalan +5 more
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Bacterial Superantigen Toxins, CD28, and Drug Development
Toxins, 2018 During severe bacterial infections, death and disease are often caused by an overly strong immune response of the human host. Acute toxic shock is induced by superantigen toxins, a diverse set of proteins secreted by Gram-positive staphylococcal and ...
Raymond Kaempfer
doaj +1 more source
CD28: Direct and Critical Receptor for Superantigen Toxins
Toxins, 2013 Every adaptive immune response requires costimulation through the B7/CD28 axis, with CD28 on T-cells functioning as principal costimulatory receptor. Staphylococcal and streptococcal superantigen toxins hyperstimulate the T-cell-mediated immune response ...
Ziv Rotfogel +5 more
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Mouse Mammary Tumor Virus (MMTV) and MMTV-like Viruses: An In-depth Look at a Controversial Issue
Viruses, 2022 Since its discovery as a milk factor, mouse mammary tumor virus (MMTV) has been shown to cause mammary carcinoma and lymphoma in mice. MMTV infection depends upon a viral superantigen (sag)-induced immune response and exploits the immune system to ...
Francesca Parisi +4 more
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Assessment of the Functional Regions of the Superantigen Staphylococcal Enterotoxin B
Toxins, 2013 The functional activity of superantigens is based on capacity of these microbial proteins to bind to both the β-chain of the T cell receptor (TcR) and the major histocompatibility complex (MHC) class II dimer.
Thomas J. Rogers, Lily Zhang
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Infectious diseases and autoimmunity [PDF]
, 2011 Introduction: Autoimmunity occurs when the immune system recognizes and attacks host tissue. In addition to genetic factors, environmental triggers (in particular viruses, bacteria and other infectious pathogens) are thought to play a major role in the ...
Deidda, Silvia +3 more
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SARS-CoV-2 Spike Does Not Possess Intrinsic Superantigen-like Inflammatory Activity
Cells, 2022 Multisystem inflammatory syndrome in children (MIS-C) is a rare hyperinflammatory disease occurring several weeks after SARS-CoV-2 infection. The clinical similarities between MIS-C and the toxic shock syndrome, together with the preferential expansion ...
Carola Amormino +7 more
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Mikrobiyoloji Bulteni, 2016 Superantigens (SAgs) are microbial proteins produced by various microorganisms that elicit excessive and strong stimulation of T cells via an unconventional mechanism. They cause polyclonal activation of T cells in a non-specific manner, by binding to a particular variable-beta (Vβ) chain of T-cell receptor (TCR) and MHC class II molecule, in ...
openaire +2 more sources
Positive selection of V beta 8+ CD4-8- thymocytes by class I molecules expressed by hematopoietic cells. [PDF]
, 1993 A small subset of T cells of mature phenotype express the alpha/beta T cell receptor, but not CD4 and CD8 coreceptors (alpha/beta double-negative [DN] cells).
Bix, M, Coles, M, RAULET, David H.
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Marginal zone B-cells, a gatekeeper of innate immunity
Frontiers in Immunology, 2011 To maintain the integrity of an organism constantly challenged by pathogens, the immune system is endowed with a variety of cell types. B-lymphocytes were initially thought to only play a role in the adaptative branch of immunity.
Moncef eZOUALI, Yolande eRICHARD
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