Results 91 to 100 of about 15,229 (210)

Characterization of the Thermal Stability of Type I Collagen Extracted From Atlantic Cod (Gadus morhua) Skin

Chemistry–Methods, Volume 6, Issue 10, October 2026.
Type I collagen extracted from salted Atlantic cod skin is evaluated for thermal stability using complementary structural techniques. The triple‐helical structure remains preserved up to 20°C, while higher temperatures induce progressive denaturation.
Abolfazl Keshmirshekan, Paulo Ribeiro‐Claro, João A. P. Coutinho, Sónia P. M. Ventura   +3 more
wiley   +1 more source

Building coiled coils with polar cores

Protein Science, Volume 35, Issue 10, October 2026.
Abstract Coiled coils are formed by α‐helices winding around each other into superhelical bundles. They are characterized by a specific geometry of interaction, called knobs‐into‐holes, in which residues in the core of the structure mesh regularly along a seam that runs the length of the helices.
Marcus D. Hartmann, Birte Hernandez Alvarez, Mikel Martinez‐Goikoetxea, Andrei N. Lupas   +3 more
wiley   +1 more source

Targeting homologous recombination repair to potentiate fluoroquinolone efficacy in Mycobacterium abscessus

mLife, EarlyView.
Shuai Wang, Md Shah Alam, Buhari Yusuf, Jingran Zhang, Ziwen Lu, Xiaofan Zhang, H. M. Adnan Hameed, Mst. Sumaia Khatun, Chunyu Li, Lijie Li, Aleksey A. Vatlin, Aweke M. Belachew, Xirong Tian, Yamin Gao, Cuiting Fang, Rogers P. Zhang, Jun Li, Xinyue Wang, Liqiang Feng, Li Wan, Tianyu Zhang   +20 more
wiley   +1 more source

Metagenomic Characterisation of Antibiotic Resistance in Anaerobic Digesters and Their Implications for Environmental Health

Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.
Anaerobic digester metagenomes revealed diverse resistance‐associated annotations and antibiotic target loci, highlighting their potential role in environmental AMR surveillance. The findings emphasise the need for cautious interpretation of resistome profiles and further host‐resolved analyses to determine the mobility and clinical relevance of ...
Olasunbo Aina Olasupo, Oluwaseyi Paul Olaniyan, Sunday Babatunde Akinde, Ademola Ayodele Adesoye, Fatimah Adenike Ajadi, Omokaro Obire, Elijah Kolawole Oladipo, Waidi Folorunso Sule, Olamilekan Emmanuel Oyinloye, Adedolapo Aishat Salami, Emmanuel Sunday Fajoyegbe, Adejoke Janet Ajani, Olabisi Ojo   +12 more
wiley   +1 more source

Variation of Structure and Cellular Functions of Type IA Topoisomerases across the Tree of Life

Cells
Topoisomerases regulate the topological state of cellular genomes to prevent impediments to vital cellular processes, including replication and transcription from suboptimal supercoiling of double-stranded DNA, and to untangle topological barriers ...
Kemin Tan, Yuk-Ching Tse-Dinh
doaj   +1 more source

Doxorubicin and 4‐Hydroperoxycyclophosphamide Alter Mitochondrial Dynamics and miR‐34 Expression in Spermatogonia and Spermatocytes In Vitro

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Doxorubicin (DOX) and cyclophosphamide (CP) are widely used chemotherapeutic agents with known gonadotoxic effects. Since miRNAs play a key role in the transcriptional regulation of spermatogenesis, they are suggested as biomarkers for male infertility.
Hülya Öztatlıcı, Mahmut Kemal Özbilgin, Rukiye Betül Çolaksel, Suna Karadeniz Saygılı, Mustafa Öztatlıcı   +4 more
wiley   +1 more source

DNA as a Double-Coding Device for Information Conversion and Organization of a Self-Referential Unity

DNA
Living systems are capable on the one hand of eliciting a coordinated response to changing environments (also known as adaptation), and on the other hand, they are capable of reproducing themselves.
Georgi Muskhelishvili, William Nasser, Sylvie Reverchon, Andrew Travers   +3 more
doaj   +1 more source

Application of Plasmid Engineering to Enhance Yield and Quality of Plasmid for Vaccine and Gene Therapy

Bioengineering, 2019
There is an increased interest in plasmid DNA as therapeutics. This is evident in the number of ongoing clinical trials involving the use of plasmid DNA.
Olusegun Folarin, Darren Nesbeth, John M. Ward, Eli Keshavarz-Moore   +3 more
doaj   +1 more source

The Role of torS and torT Transcription in Driving a Bet‐Hedging Strategy for Trimethylamine N‐Oxide Reductase Expression in Escherichia coli

Molecular Microbiology, Volume 126, Issue 4, Page 379-395, October 2026.
Low basal activity of divergent promoters driving transcription of the trimethylamine N‐oxide (TMAO) sensor TorT and kinase TorS is integral to an O2‐regulated bet‐hedging strategy for continued E. coli growth upon the onset of anaerobiosis. This, along with repression by IscR, promotes noise in the TorS to TorT ratio, which is critical for adaptation ...
Erin L. Mettert, Jeffrey N. Carey, Wilma Ross, Mark Goulian, Patricia J. Kiley   +4 more
wiley   +1 more source

A Genome-Wide Evolutionary Simulation of the Transcription-Supercoiling Coupling: extended version

, 2022
Extended version of the ALIFE21 paper (https://hal.archives-ouvertes.fr/hal-03242696), to appear in the Artificial Life journal.DNA supercoiling, the level of under-or overwinding of the DNA polymer around itself, is widely recognized as an ancestral ...
Beslon, Guillaume, Meyer, Sam, Grohens, Théotime   +2 more
core   +2 more sources