Results 71 to 80 of about 22,006 (218)
Chemistry – A European Journal, EarlyView.5‐Substituted 2‐(naphthalen‐2‐yl)‐4H‐chromen‐4‐ones are reported as a novel class of highly potent and selective triplex DNA ligands. These ligands induce triplex formation at submicromolar concentrations and inhibit enzymatic activity via ligand‐mediated triplex formation.
Nghia Tran +4 more
wiley +1 more source
Journal of Cell Science, 1975 ABSTRACT The three-dimensional structure of a double-stranded DNA molecule may be described by distinguishing the helical turns of the DNA duplex from any superhelical turns that might be superimposed upon the duplex turns. There are characteristic changes in the hydrodynamic properties of superhelical DNA molecules when they interact ...
Cook, P, Brazell, I
openaire +3 more sources
Dimensions of plectonemically supercoiled DNA [PDF]
Acta Crystallographica Section A Foundations of Crystallography, 2002 With a view to determine the configuration and regularity of plectonemically supercoiled DNA, we have measured the small angle neutron scattering from pUC18 plasmid in saline solutions. Furthermore, we have derived the mathematical expression for the single chain scattering function (form factor) of a superhelical structure, including the longitudinal ...
Zakharova, Svetlana S. +5 more
openaire +3 more sources
DNA Supercoiling: an Ancestral Regulator of Gene Expression in Pathogenic Bacteria?
Computational and Structural Biotechnology Journal, 2019 DNA supercoiling acts as a global and ancestral regulator of bacterial gene expression. In this review, we advocate that it plays a pivotal role in host-pathogen interactions by transducing environmental signals to the bacterial chromosome and ...
Shiny Martis B. +4 more
doaj +1 more source
Polymer induced condensation of dna supercoils [PDF]
, 2008 Macromolecular crowding is thought to be a significant factor driving DNA condensation in prokaryotic cells. Whereas DNA in prokaryotes is supercoiled, studies on crowding-induced DNA condensation have so far focused on linear DNA.
Bessa Ramos Jr., J.E. +2 more
core +2 more sources
FlexMat, EarlyView.Abstract Soft robots, engineered from highly compliant materials, offer superior adaptability and safety in unstructured environments compared to their rigid counterparts. Recent advancements, fueled by bio‐inspiration and material programmability, have led to the rapid co‐evolution of their core modules: actuation, sensing, protection, energy, and ...
Qiulei Liu +3 more
wiley +1 more source
Nucleic Acids Research, 2018 Topologically associating domains (TADs) are megabase-sized building blocks of interphase chromosomes in higher eukaryotes. TADs are chromosomal regions with increased frequency of internal interactions. On average a pair of loci separated by a given genomic distance contact each other 2-3 times more frequently when they are in the same TAD as compared
Dusan Racko +3 more
openaire +3 more sources
The plusses and minuses of DNA torsion
eLifeA new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.
Steven Henikoff, David L Levens
doaj +1 more source
Helix untwisting and bubble formation in circular DNA [PDF]
, 2013 The base pair fluctuations and helix untwisting are examined for a circular molecule. A realistic mesoscopic model including twisting degrees of freedom and bending of the molecular axis is proposed.
Bates A. D. +3 more
core +2 more sources
Role of Supercoiling and Topoisomerases in DNA Knotting
DNADNA knots are deleterious for living cells if not removed. Several theoretical and simulation approaches address the question of how topoisomerases select the intermolecular passages that preferentially lead to unknotting rather than to the knotting of ...
Jorge Cebrián +6 more
doaj +1 more source