Results 61 to 70 of about 15,229 (210)
A fundamental regulatory mechanism operating through OmpR and DNA topology controls expression of Salmonella pathogenicity islands SPI-1 and SPI-2. [PDF]
PLoS Genetics, 2012 DNA topology has fundamental control over the ability of transcription factors to access their target DNA sites at gene promoters. However, the influence of DNA topology on protein-DNA and protein-protein interactions is poorly understood.
Andrew D S Cameron, Charles J Dorman
doaj +1 more source
Advanced Science, EarlyView.This study characterizes MfAgo, an enzyme exhibiting highly efficient DNA‐guided DNA and RNA cleavage capability. Precise RNA cleavage strictly requires dimerization to stabilize the PIWI‐loop region, while its robust DNA cleavage functions in a dimerization‐independent manner.
Fuyong Huang +9 more
wiley +1 more source
Advanced Intelligent Systems, EarlyView.We developed methods to characterize soft contractile actuators using force–displacement measurements in the passive state and the total force in the active state and define the operational range of thermal, electrothermal, and pneumatic muscles. A graphical method enables the selection of an actuator based on the required mechanical force–displacement
Qiong Wang +5 more
wiley +1 more source
Studies of DNA supercoiling in vivo and in vitro [PDF]
, 1990 This thesis describes a number of diverse experiments whose common theme is to elaborate some aspect of DNA supercoiling. The torsion elastic constant of DNA is measure as a function of superhelix density using the technique of picosecond Time Resolved ...
Cook, D. N.
core +2 more sources
DNA Supercoiling: an Ancestral Regulator of Gene Expression in Pathogenic Bacteria?
Computational and Structural Biotechnology Journal, 2019 DNA supercoiling acts as a global and ancestral regulator of bacterial gene expression. In this review, we advocate that it plays a pivotal role in host-pathogen interactions by transducing environmental signals to the bacterial chromosome and ...
Shiny Martis B. +4 more
doaj +1 more source
The plusses and minuses of DNA torsion
eLifeA new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.
Steven Henikoff, David L Levens
doaj +1 more source
DNA knots and DNA supercoiling [PDF]
Cell Cycle, 2011 Keywords: DNA topoisomerases; DNA topology; DNA structure Reference EPFL-ARTICLE-167094doi:10.4161/cc.10.9.15293View record in Web of Science Record created on 2011-06-24, modified on 2017-05 ...
Witz, Guillaume +2 more
openaire +3 more sources
Cellular Strategies for Regulating DNA Supercoiling: A Single-Molecule Perspective [PDF]
, 2010 Entangling and twisting of cellular DNA (i.e., supercoiling) are problems inherent to the helical structure of double-stranded DNA. Supercoiling affects transcription, DNA replication, and chromosomal segregation.
Koster, Daniel A. +9 more
core +1 more source
Modulation of Epigenetic Control by Advanced Molecular Tweezers
Chemistry – A European Journal, EarlyView.Tailored dimeric molecular tweezers recognize the DNA‐binding part of Histone H4 and interrupt the essential histone‐DNA interaction. ABSTRACT This work addresses the question if supramolecular systems can be tailored to interfere with posttranslational modifications (PTM) and epigenetics.
My‐Hue‐Le +9 more
wiley +1 more source
Role of Supercoiling and Topoisomerases in DNA Knotting
DNADNA knots are deleterious for living cells if not removed. Several theoretical and simulation approaches address the question of how topoisomerases select the intermolecular passages that preferentially lead to unknotting rather than to the knotting of ...
Jorge Cebrián +6 more
doaj +1 more source