Results 51 to 60 of about 22,006 (218)

Quinolones: Mechanism, Lethality and Their Contributions to Antibiotic Resistance

Molecules, 2020
Fluoroquinolones (FQs) are arguably among the most successful antibiotics of recent times. They have enjoyed over 30 years of clinical usage and become essential tools in the armoury of clinical treatments. FQs target the bacterial enzymes DNA gyrase and
Natassja G. Bush, Isabel Diez-Santos, Lauren R. Abbott, Anthony Maxwell   +3 more
doaj   +1 more source

Structural interplay between DNA-shape protein recognition and supercoiling: The case of IHF

Computational and Structural Biotechnology Journal, 2022
The integration host factor (IHF) is a prominent example of indirect readout as it imposes one of the strongest bends on relaxed linear DNA. However, the relation between IHF and torsionally constrained DNA, as occurs physiologically, remains unclear. By
George D. Watson, Elliot W. Chan, Mark C. Leake, Agnes Noy   +3 more
doaj   +1 more source

Resonant Domain Wall Dynamics in a Three‐Dimensional Magnetic Nano Double Helix

Advanced Materials, EarlyView.
3D magnetic nanostructures promise exciting possibilities for magnetization dynamics. However, experimental realizations remain scarce. In nanoprinted cobalt double helices, time‐resolved X‐ray microscopy reveals harmonic domain wall dynamics. Simulations identify the mode and additional higher‐frequency resonances, revealing a rich dynamic landscape ...
Pamela Morales‐Fernández, Iason Konstantinos‐Douveas, Claas Abert, Elina Zhakina, Sandra Ruiz‐Gómez, Claudia Fernández‐González, Luke Alexander Turnbull, Sebastian Wintz, Markus König, Simone Finizio, Markus Weigand, Naëmi Leo, Dieter Suess, Aurelio Hierro‐Rodríguez, Amalio Fernández‐Pacheco, Claire Donnelly   +15 more
wiley   +1 more source

Effects of DNA Topology on Transcription from rRNA Promoters in Bacillus subtilis

Microorganisms, 2021
The expression of rRNA is one of the most energetically demanding cellular processes and, as such, it must be stringently controlled. Here, we report that DNA topology, i.e., the level of DNA supercoiling, plays a role in the regulation of Bacillus ...
Petra Sudzinová, Milada Kambová, Olga Ramaniuk, Martin Benda, Hana Šanderová, Libor Krásný   +5 more
doaj   +1 more source

Macroscopic loop formation in circular DNA denaturation

, 2012
The statistical mechanics of DNA denaturation under fixed linking number is qualitatively different from that of the unconstrained DNA. Quantitatively different melting scenarios are reached from two alternative assumptions, namely, that the denatured ...
Alkan Kabakçıoğlu, Amir Bar, B. Alberts, David Mukamel   +3 more
core   +3 more sources

Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures [PDF]

, 2013
DNA supercoiling is an inherent consequence of twisting DNA and is critical for regulating gene expression and DNA replication. However, DNA supercoiling at a genomic scale in human cells is uncharacterized.
A Saunders, AC Seila, AF Stewart, AS Belmont, B Schuster-Böckler, B Villeponteau, B Villeponteau, Bauke Ylstra, C Hou, C Naughton, C Naughton, Catherine Naughton, D Sproul, DS Gilmour, DS Gilmour, EP Nora, F Pedone, G Bernardi, GD Cimino, GN Giaever, H Caron, H Tabuchi, H Weintraub, I Bermúdez, Ioulia K Mati, J Filipski, James G Prendergast, JK Stock, JR Dixon, LF Liu, LJ Core, M Costantini, M Dunaway, M Ljungman, M Ljungman, M Merkenschlager, M Mizutani, M Mizutani, Mark Bradley, MC Schultz, MJ Lercher, MP Marsden, MT Tomic, MV Blagosklonny, N Gilbert, N Hay, Nick Gilbert, Nicolaos Avlonitis, P Preker, Paul P Eijk, R Métivier, R Versteeg, RD Kornberg, RK Sachs, RR Sinden, RS Joshi, S Chambeyron, Samuel Corless, Scott L Cockroft, WA Saffran, Y Hu, Y Zhou   +61 more
core   +2 more sources

Functional Fibers in Soft Robotics: Advances in Material, Structural, and Systemic Tactics

Advanced Robotics Research, EarlyView.
Fiber‐form robotic systems offer a scalable pathway toward embodied intelligence in soft robotics. This review surveys functional fibers as material, structural, and systemic elements, highlighting advances in responsive materials, architectural programing, and fabrication strategies.
Joonhee Won, Jaehyun Jang, Hyeonseo Kim, Inyoung Choi, Steve Park, Seongjun Park   +5 more
wiley   +1 more source

Evidence for a Solenoid Phase of Supercoiled DNA

, 2018
In mechanical manipulation experiments, a single DNA molecule overwound at constant force undergoes a discontinuous drop in extension as it buckles and forms a superhelical loop (a plectoneme).
Dittmore, Andrew, Neuman, Keir C.
core   +1 more source

Hierarchical Artificial Muscle with Nonlinear Elasticity for Antagonistic and Cyclic Robotics

Advanced Science, EarlyView.
We construct hierarchical muscles by plying nylon fibers around a heating wire. The hierarchical muscle shows a J‐shaped passive curve, which shows benefit in antagonistic muscle pair and work accumulation mechanism. We also develop a computational, first‐principle model to understand the physics of both active actuation stroke and passive J‐curve ...
Samuel Tsai, Liuyang Cheng, Ali Albazroun, Qiong Wang, Jeongmin Kim, Arman Tekinalp, Soonwook Kim, Charlie Simcox, Ryne Downing, Vagish Sivaramakrishnan, Grace Carsello, Miles Bimrose, Wonsik Eom, William P. King, Mattia Gazzola, Sameh Tawfick   +15 more
wiley   +1 more source

Behavior of Supercoiled DNA [PDF]

Biophysical Journal, 1998
We study DNA supercoiling in a quantitative fashion by micromanipulating single linear DNA molecules with a magnetic field gradient. By anchoring one end of the DNA to multiple sites on a magnetic bead and the other end to multiple sites on a glass surface, we were able to exert torsional control on the DNA. A rotating magnetic field was used to induce
Strick, T.R., Allemand, J.-F., Bensimon, D., Croquette, V.   +3 more
openaire   +2 more sources