Results 31 to 40 of about 22,006 (218)

Counterintuitive DNA Sequence Dependence in Supercoiling-Induced DNA Melting.

PLoS ONE, 2015
The metabolism of DNA in cells relies on the balance between hybridized double-stranded DNA (dsDNA) and local de-hybridized regions of ssDNA that provide access to binding proteins.
Rifka Vlijm, Jaco V D Torre, Cees Dekker
doaj   +1 more source

A fluoroquinolone resistance associated mutation in gyrA affects DNA supercoiling in Campylobacter jejuni

Frontiers in Cellular and Infection Microbiology, 2012
The prevalence of fluoroquinolone (FQ)-resistant Campylobacter has become a concern for public health. To facilitate the control of FQ-resistant Campylobacter, it is necessary to understand the impact of FQ resistance on the fitness of Campylobacter in ...
Jing eHan, Yang eWang, Yang eWang, Orhan eSahin, Zhangqi eShen, Baoqing eGuo, Jianzhong eShen, Qijing eZhang   +7 more
doaj   +1 more source

Transcription as a Threat to Genome Integrity [PDF]

, 2016
Genomes undergo different types of sporadic alterations, including DNA damage, point mutations, and genome rearrangements, that constitute the basis for evolution.
Aguilera López, Andrés, Gaillard, Hélène   +1 more
core   +1 more source

The Viscous Nonlinear Dynamics of Twist and Writhe [PDF]

, 1998
Exploiting the "natural" frame of space curves, we formulate an intrinsic dynamics of twisted elastic filaments in viscous fluids. A pair of coupled nonlinear equations describing the temporal evolution of the filament's complex curvature and twist ...
A. E. H. Love, A. Goriely, B. Alberts, C. H. Wiggins, C. Levinthal, Chris H. Wiggins, D'Arcy W. Thompson, D. Riveline, F. B. Fuller, F. B. Fuller, G. Căluguăreanu, G. Darboux, G. Kirchhoff, H. Hasimoto, I. Klapper, I. Klapper, J. F. Marko, J. H. White, J. J. Thwaites, J. M. Schurr, K. Nakayama, L. D. Landau, L. F. Liu, M. D. Barkley, M. Doi, M. J. Tilby, N. H. Mendelson, N. H. Mendelson, N. H. Mendelson, R. D. Kamien, R. E. Goldstein, R. L. Bishop, Raymond E. Goldstein, T. Y. Hou, Thomas R. Powers, Y. Shi   +35 more
core   +3 more sources

Genome scale patterns of supercoiling in a bacterial chromosome

Nature Communications, 2016
Bacterial DNA primarily exists in a negatively supercoiled or under-wound state. Here, by mapping the supercoiling state, the authors show that there is a gradient of supercoiling across the bacterial chromosome with the terminus being more negatively ...
Avantika Lal, Amlanjyoti Dhar, Andrei Trostel, Fedor Kouzine, Aswin S. N. Seshasayee, Sankar Adhya   +5 more
doaj   +1 more source

Transposition Behavior Revealed by High-Resolution Description of Pseudomonas Aeruginosa Saltovirus Integration Sites

Viruses, 2018
Transposable phages, also called saltoviruses, of which the Escherichia coli phage Mu is the reference, are temperate phages that multiply their genome through replicative transposition at multiple sites in their host chromosome.
Gilles Vergnaud, Cédric Midoux, Yann Blouin, Maria Bourkaltseva, Victor Krylov, Christine Pourcel   +5 more
doaj   +1 more source

Gene clusters reflecting macrodomain structure respond to nucleoid perturbations

, 2010
Focusing on the DNA-bridging nucleoid proteins Fis and H-NS, and integrating several independent experimental and bioinformatic data sources, we investigate the links between chromosomal spatial organization and global transcriptional regulation.
Alberts, Ashburner, Babu, Ball, Beloin, Berger, Bertin, Bianca Sclavi, Blot, Boccard, Bradley, Bruno Bassetti, Cabrera, Cabrera, Cases, Chilcott, Cho, Cho, Cook, Cunha, Cunha, Dame, Darling, Dillon, Dorman, Duan, Eisen, Esnault, Espéli, Espéli, Fang, Gama-Castro, Grainger, Hengen, Hengge, Janga, Jeong, Jin, Junier, Kahramanoglou, Kalir, Kalir, Kelly, Keseler, Ko, Korea, Krin, Képès, Képès, Lang, Liu, Luijsterburg, Marco Cosentino Lagomarsino, Marr, Mathelier, Mercier, Moulin, Muskhelishvili, Nielsen, Oberto, Ogasawara, Oshima, Pesavento, Peter, Postow, Prigent-Combaret, Prüss, Reyes-Lamothe, Rocha, Saldana, Serres, Smith, Sonnenschein, Soutourina, Soutourina, Soutourina, Travers, Valens, Vittore F. Scolari, Vora, Wade, Wang, Wang, Wang, Warren, Weber, Wiggins, Wright, Zechiedrich, Zimmerman   +89 more
core   +2 more sources

The Transcriptome of Streptococcus pneumoniae Induced by Local and Global Changes in Supercoiling

Frontiers in Microbiology, 2017
The bacterial chromosome is compacted in a manner optimal for DNA transactions to occur. The degree of compaction results from the level of DNA-supercoiling and the presence of nucleoid-binding proteins.
Adela G. de la Campa, Adela G. de la Campa, María J. Ferrándiz, Antonio J. Martín-Galiano, María T. García, Jose M. Tirado-Vélez   +5 more
doaj   +1 more source

The bacterial promoter spacer modulates promoter strength and timing by length, TG-motifs and DNA supercoiling sensitivity

Scientific Reports, 2021
Transcription, the first step to gene expression, is a central coordination process in all living matter. Besides a plethora of regulatory mechanisms, the promoter architecture sets the foundation of expression strength, timing and the potential for ...
Carlo A. Klein, Marc Teufel, Carl J. Weile, Patrick Sobetzko   +3 more
doaj   +1 more source

Towards Conformation-Sensitive Inhibition of Gyrase: Implications of Mechanistic Insight for the Identification and Improvement of Inhibitors

Molecules, 2021
Gyrase is a bacterial type IIA topoisomerase that catalyzes negative supercoiling of DNA. The enzyme is essential in bacteria and is a validated drug target in the treatment of bacterial infections.
Dagmar Klostermeier
doaj   +1 more source