Results 11 to 20 of about 22,006 (218)
An Experimental Framework to Examine the Influence of Promoter Architecture and Genomic Context on Gene Expression [PDF]
, 2020 Transcription is a fundamental process of gene expression. Information stored in DNA is transcribed into different types of mobile RNA, which play a role in various essential processes of the cell, e.g. translation.
Klein, Carlo Anton
core +1 more source
Supercoiling DNA Locates Mismatches [PDF]
Physical Review Letters, 2017 We present a method of detecting sequence defects by supercoiling DNA with magnetic tweezers. The method is sensitive to a single mismatched base pair in a DNA sequence of several thousand base pairs. We systematically compare DNA molecules with 0 to 16 adjacent mismatches at 1Mmonovalent salt and 3.5 pN force and show that, under these conditions, a ...
Dittmore, Andrew +4 more
openaire +4 more sources
High-resolution, genome-wide mapping of positive supercoiling in chromosomes
eLife, 2021 Supercoiling impacts DNA replication, transcription, protein binding to DNA, and the three-dimensional organization of chromosomes. However, there are currently no methods to directly interrogate or map positive supercoils, so their distribution in ...
Monica S Guo +4 more
doaj +1 more source
Hepatology, EarlyView., 2022 Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro +17 more
wiley +1 more source
Data in Brief, 2020 In enteric bacteria, DNA supercoiling is highly responsive to environmental conditions. Host specific features of environment serve as cues for the expression of genes required for colonization of host niches via changing supercoiling [1].
Natalia E. Gogoleva +4 more
doaj +1 more source
Biology, 2021 We propose a model for cohesin-mediated loop extrusion, where the loop extrusion is driven entropically by the energy difference between supercoiled and torsionally relaxed chromatin fibers.
Renáta Rusková, Dušan Račko
doaj +1 more source
DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines.
PLoS Genetics, 2020 DNA supercoiling is essential for all living cells because it controls all processes involving DNA. In bacteria, global DNA supercoiling results from the opposing activities of topoisomerase I, which relaxes DNA, and DNA gyrase, which compacts DNA. These
Alexandre Duprey, Eduardo A Groisman
doaj +1 more source
Role of the Discriminator Sequence in the Supercoiling Sensitivity of Bacterial Promoters
mSystems, 2021 DNA supercoiling acts as a global transcriptional regulator that contributes to the rapid transcriptional response of bacteria to many environmental changes.
Raphaël Forquet +4 more
doaj +1 more source
Divergent RNA transcription:A role in promoter unwinding? [PDF]
, 2013 New approaches using biotinylated-psoralen as a probe for investigating DNA structure have revealed new insights into the relationship between DNA supercoiling, transcription and chromatin compaction.
Corless, Samuel +2 more
core +1 more source
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling. [PDF]
, 2020 The CRISPR-Cas9 nuclease has been widely repurposed as a molecular and cell biology tool for its ability to programmably target and cleave DNA. Cas9 recognizes its target site by unwinding the DNA double helix and hybridizing a 20-nucleotide section of ...
Aris, Kevin D Palacio +5 more
core +3 more sources