Results 21 to 30 of about 15,229 (210)
Hepatology, EarlyView., 2022 Adaptive mitochondrial mechanisms allow mitochondrial resilience and prevent the worsening of fibrosis, while deregulation of these mechanisms promotes the progression from no/minimal‐mild (F0‐F2) fibrosis to advanced fibrosis and cirrhosis (F3‐F4). Abstract Background and Aims Hepatitis B virus (HBV) infection causes oxidative stress (OS) and alters ...
Dimitri Loureiro +17 more
wiley +1 more source
Biology, 2021 We propose a model for cohesin-mediated loop extrusion, where the loop extrusion is driven entropically by the energy difference between supercoiled and torsionally relaxed chromatin fibers.
Renáta Rusková, Dušan Račko
doaj +1 more source
Divergent RNA transcription:A role in promoter unwinding? [PDF]
, 2013 New approaches using biotinylated-psoralen as a probe for investigating DNA structure have revealed new insights into the relationship between DNA supercoiling, transcription and chromatin compaction.
Gilbert, Nick +2 more
core +1 more source
Nucleic Acids Research, 2018 Topologically associating domains (TADs) are megabase-sized building blocks of interphase chromosomes in higher eukaryotes. TADs are chromosomal regions with increased frequency of internal interactions. On average a pair of loci separated by a given genomic distance contact each other 2-3 times more frequently when they are in the same TAD as compared
Dusan Racko +3 more
openaire +4 more sources
mBio, 2016 Campylobacter jejuni is the leading cause of bacterial gastroenteritis in humans, but relatively little is known about the global regulation of virulence factors during infection of chickens or humans.
Claire Shortt +5 more
doaj +1 more source
DNA supercoiling differences in bacteria result from disparate DNA gyrase activation by polyamines.
PLoS Genetics, 2020 DNA supercoiling is essential for all living cells because it controls all processes involving DNA. In bacteria, global DNA supercoiling results from the opposing activities of topoisomerase I, which relaxes DNA, and DNA gyrase, which compacts DNA. These
Alexandre Duprey, Eduardo A Groisman
doaj +1 more source
Role of the Discriminator Sequence in the Supercoiling Sensitivity of Bacterial Promoters
mSystems, 2021 DNA supercoiling acts as a global transcriptional regulator that contributes to the rapid transcriptional response of bacteria to many environmental changes.
Raphaël Forquet +4 more
doaj +1 more source
Stochastic Model of Supercoiling-Dependent Transcription [PDF]
, 2016 We propose a stochastic model for gene transcription coupled to DNA supercoiling, where we incorporate the experimental observation that polymerases create supercoiling as they unwind the DNA helix and that these enzymes bind more favorably to regions ...
Gilbert, N. +8 more
core +1 more source
Frontiers in Molecular Biosciences, 2023 One of the biggest paradoxes in biology is that human genome is roughly 2 m long, while the nucleus containing it is almost one million times smaller.
Laura Martin +7 more
doaj +1 more source
Thermal Shifts Dominate Single-Gene Responses to Transcription-Targeting Antibiotics. [PDF]
Adv Sci (Weinh)Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Jagadeesan R +5 more
europepmc +2 more sources