Results 81 to 90 of about 22,006 (218)

A Novel Antioxidant Peptide Cath‐Np Derived from Nanorana parkeri Attenuates UVB‐Induced Skin Photodamage in Mice

Integrative Zoology, EarlyView.
Schematic representation of Cath‐Np as an antioxidant suppressing acute skin damage caused by ultraviolet B (UVB) radiation in mice. Cath‐Np inhibits the activation of p53 and mitogen‐activated protein kinase pathways while it activates the Nrf2 pathway by its strong antioxidant effects, and accordingly suppresses the expression of inflammatory factors
Hang Liao, Xiaoxiao Shen, Jinwei Chai, Kai wang, Jiena Wu, Jianxi Yang, Ming Chen, Guoxiang Mo, Xueqing Xu   +8 more
wiley   +1 more source

Topological and geometrical entanglement in a model of circular DNA undergoing denaturation

, 2002
The linking number (topological entanglement) and the writhe (geometrical entanglement) of a model of circular double stranded DNA undergoing a thermal denaturation transition are investigated by Monte Carlo simulations. By allowing the linking number to
Baiesi, M., Orlandini, E., Stella, A. L.
core   +1 more source

Controlled rotation mechanism of DNA strand exchange by the Hin serine recombinase. [PDF]

, 2016
DNA strand exchange by serine recombinases has been proposed to occur by a large-scale rotation of halves of the recombinase tetramer. Here we provide the first direct physical evidence for the subunit rotation mechanism for the Hin serine invertase ...
Johnson, Reid C, Lei, Xianbin, Marko, John F, McLean, Meghan M, Xiao, Botao   +4 more
core   +1 more source

Advancing collagen‐related pathology assessment through second‐harmonic generation imaging

Journal of Microscopy, EarlyView.
Abstract Collagen remodelling and dysregulation are the hallmarks of diverse pathological conditions. In this context, second‐harmonic generation (SHG) imaging has emerged as a powerful label‐free modality for assessing collagen. This offers submicron resolution, intrinsic optical sectioning, and deeper imaging capabilities without the need for ...
Jackson Rodrigues, Manikanth Karnati, Gagan Raju, Edwin Pious, Ankur Gogoi, Guan‐Yu Zhuo, Nirmal Mazumder, Fu‐Jen Kao   +7 more
wiley   +1 more source

DNA supercoiling during transcription

Biophysical Reviews, 2016
The twin-supercoiled-domain model describes how transcription can drive DNA supercoiling, and how DNA supercoiling, in turn plays an important role in regulating gene transcription. In vivo and in vitro experiments have disclosed many details of the complex interactions in this relationship, and recently new insights have been gained with the help of ...
Jie Ma, Michelle D. Wang
openaire   +3 more sources

Nucleation at the DNA supercoiling transition

, 2011
Twisting DNA under a constant applied force reveals a thermally activated transition into a state with a supercoiled structure known as a plectoneme. Using transition state theory, we predict the rate of this plectoneme nucleation to be of order 10^4 Hz.
Bryan C. Daniels, C. Mülhardt, E. N. Trifonov, James P. Sethna, P. S. Doyle, S. Coleman   +5 more
core   +1 more source

Methionine Synthase Positively Regulates Plant Defence to Both RNA and DNA Viruses and Is Useful for Developing Broad‐Spectrum Antiviral Resistance in Crops

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant viruses frequently cause severe economic losses in worldwide crop production. Developing broad‐spectrum resistance is the most efficient approach for controlling plant viral diseases. In this work, we found that the 17K protein of barley yellow dwarf viruses (BYDVs), which has multiple functions in viral pathogenesis including acting as ...
Zhaohui Wang, Kunpu Zhang, Chi Zhang, Jin Yang, Bei Li, Lina Wang, Zhenghao Shi, Rui Guo, Shuai Zhang, Kaiqi Gao, Jianing Li, Xiaohuan Jin, Xiang Ji, Huihui Bi, Liyuan You, Huaibing Jin, Daowen Wang   +16 more
wiley   +1 more source

An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete

eLife, 2020
Spirochete bacteria, including important pathogens, exhibit a distinctive means of swimming via undulations of the entire cell. Motility is powered by the rotation of supercoiled 'endoflagella' that wrap around the cell body, confined within the ...
Kimberley H Gibson, Felipe Trajtenberg, Elsio A Wunder, Megan R Brady, Fabiana San Martin, Ariel Mechaly, Zhiguo Shang, Jun Liu, Mathieu Picardeau, Albert Ko, Alejandro Buschiazzo, Charles Vaughn Sindelar   +11 more
doaj   +1 more source

Transcription-induced supercoiling as the driving force of chromatin loop extrusion during formation of TADs in interphase chromosomes. [PDF]

, 2017
Using molecular dynamics simulations, we show here that growing plectonemes resulting from transcription-induced supercoiling have the ability to actively push cohesin rings along chromatin fibres.
Benedetti, F., Dorier, J., Racko, D., Stasiak, A.   +3 more
core   +1 more source

Synergistic Effects of IMP‐1700, Ciprofloxacin, and X‐Ray Radiation in Bacteria and Mammalian Cell Lines: Implications for Use in Antimicrobial‐Resistant Bacteria

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
IMP‐1700 enhances the cytotoxic effect on bacteria in combination with either ciprofloxacin (CPX) or X‐ray. In noncancerous and tumor cells, combination treatments markedly reduce viability with radiosensitizing effects. Further studies are needed to clarify the mechanism underlying IMP‐1700s effects on mammalian cells. Created in BioRender. Kjaer, A. (
Ida Vang Andersen, Ane Beth Sloth, Emilie Caroline Skuladottir Bøgestad, Christian Bernard Matthijs Poulie, Anne Skovsbo Clausen, Umberto Maria Battisti, Matthias M. Herth, Andreas Kjaer   +7 more
wiley   +1 more source