Rodent models for the analysis of tissue clock function in metabolic rhythms research [PDF]
, 2017 The circadian timing system consists on a distributed network of cellular clocks that together coordinate 24-h rhythms of physiology and behavior. Clock function and metabolism are tightly coupled, from the cellular to the organismal level.
Astiz, Mariana +3 more
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FORMATION OF BIOLOGICAL RHYTHMS IN PRENATAL HUMAN ONTOGENESIS
Неонатологія, хірургія та перинатальна медицина, 2019 The formation of biological rhythms in prenatal period is associated with ontogenesis of suprachiasmatic nucleus of the hypothalamus and pineal gland, activity of micro-RNA and clock genes.
V.P. Pishak
doaj +1 more source
Intrinsic regulation of spatiotemporal organization within the suprachiasmatic nucleus. [PDF]
PLoS ONE, 2011 The mammalian pacemaker in the suprachiasmatic nucleus (SCN) contains a population of neural oscillators capable of sustaining cell-autonomous rhythms in gene expression and electrical firing.
Jennifer A Evans +3 more
doaj +1 more source
Suprachiasmatic nucleus lesion increases corticosterone secretion [PDF]
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1993 The diurnal rhythm of corticosteroid secretion is controlled by the suprachiasmatic nucleus (SCN). In rats, plasma corticosteroid levels rise just before the onset of the activity period during the dark phase. Our previous results indicated that vasopressin as a neurotransmitter from the SCN inhibited corticosteroid secretion in the area of the ...
Buijs, R. M. +4 more
openaire +4 more sources
Circadian clocks and breast cancer [PDF]
, 2016 Circadian clocks respond to environmental time cues to coordinate 24-hour oscillations in almost every tissue of the body. In the breast, circadian clocks regulate the rhythmic expression of numerous genes.
Blakeman, V +3 more
core +2 more sources
TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses
Nature Communications, 2020 The suprachiasmatic nucleus (SCN) ensures rhythmic electrical activity that varies between day and night to determine circadian behaviours. The authors show that TRESK channels provide a feedback mechanism to maintain the SCN in the appropriate state for
Tatjana Lalic +7 more
doaj +1 more source
Neurocardiovascular deficits in the Q175 mouse model of Huntington's disease. [PDF]
, 2017 Cardiovascular dysautonomia as well as the deterioration of circadian rhythms are among the earliest detectable pathophysiological changes in individuals with Huntington's disease (HD). Preclinical research requires mouse models that recapitulate disease
Colwell, Christopher S +7 more
core +1 more source
The role and implications of mammalian cellular circadian entrainment
FEBS Letters, EarlyView.At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour
Nature Communications, 2016 The suprachiasmatic nucleus (SCN) is the central regulator of circadian rhythms. Here the authors identify mouse Gpr176 as a pace modulator of this circadian clock and characterize its mode of action as coupling to Gz rather than Gi subunits.
Masao Doi +17 more
doaj +1 more source
Roles of estrogen receptor-alpha in mediating life span: the hypothalamic deregulation hypothesis. [PDF]
, 2017 In several species caloric restriction (CR) extends life span. In this paper we integrate data from studies on CR and other sources to articulate the hypothalamic deregulation hypothesis by which estrogen receptor-alpha (ER-α) signaling in the ...
Barakat, Rita +6 more
core +1 more source