Results 261 to 270 of about 1,012,835 (322)
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Surface Solid Dispersion – A Review
International Journal of Pharmaceutical Sciences and Nanotechnology, 2013Preparation of an effective formulation of poorly water-soluble drugs is a key challenge in pharmaceutical technology. Dissolution rate and solubility are the rate- limiting steps for increasing the bioavailability of poorly water‐soluble drugs.
Sadhna Khatry, Neha Sood, Sandeep Arora
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Surface-attached Solid Dispersion
Journal of Pharmaceutical Investigation, 2010ABSTRACT − A novel surface-attached solid dispersion is designed to improve the solubility and oral bioavailability ofpoorly water-soluble drugs without crystalline change. Accordingly, it draws increasing interest because of excellent stabilityand no pollution for accomplishing enhanced solubility and bioavailability, which have recently been ...
Young-Joon Park +6 more
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Pharmaceutical Development and Technology, 2019
The purpose of this research was to develop a novel revaprazan-loaded surface-modified solid dispersion (SMSD) with improved drug solubility and oral bioavailability. The impact of carriers on aqueous solubility of revaprazan was investigated. HPMC and Cremophor A25 were selected as an appropriate polymer and surfactant, respectively, due to their high
Jong Hyuck Park +10 more
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The purpose of this research was to develop a novel revaprazan-loaded surface-modified solid dispersion (SMSD) with improved drug solubility and oral bioavailability. The impact of carriers on aqueous solubility of revaprazan was investigated. HPMC and Cremophor A25 were selected as an appropriate polymer and surfactant, respectively, due to their high
Jong Hyuck Park +10 more
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A novel surface-attached carvedilol solid dispersion with enhanced solubility and dissolution
Archives of Pharmacal Research, 2013A novel surface-attached, spray-dried solid dispersion containing poorly water-soluble carvedilol (CV) without any change in the crystallinity was prepared using water, polyvinylpyrrolidone (PVP K30) and Tween 80. The solid dispersion was optimized by investigating the effects of the weight ratios of Tween 80/PVP K30 and carrier/drug on the aqueous ...
Lee, Sung Neung +10 more
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Comparison of surface modification and solid dispersion techniques for drug dissolution
International Journal of Pharmaceutics, 2000Surface modification and solid dispersion formulations using hydrophilic excipients can significantly alter the dissolution behaviour of hydrophobic drug materials. The effect of these techniques used individually and in combination on the dissolution properties of the hydrophobic drug, phenylbutazone (PB), are compared. PB was treated with a poloxamer,
C, Rouchotas, O E, Cassidy, G, Rowley
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International Journal of Pharmaceutical Sciences and Nanotechnology, 1970
The objective of this investigation was to enhance the dissolution of glipizide using solid dispersions containing different superdisintegrants and to prepare rapidly disintegrating glipizide tablets with rapid absorption through the oral cavity by direct compression of the prepared solid dispersion.
A. Aly
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The objective of this investigation was to enhance the dissolution of glipizide using solid dispersions containing different superdisintegrants and to prepare rapidly disintegrating glipizide tablets with rapid absorption through the oral cavity by direct compression of the prepared solid dispersion.
A. Aly
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Surface Tracking of Curcumin Amorphous Solid Dispersions Formulated by Binary Polymers
Journal of Pharmaceutical Sciences, 2020Herein, curcumin amorphous solid dispersions (Cur ASDs) were prepared using binary polymers (Eudragit EPO with polyvinylpyrrolidone K30 [EuD-PVP], Eudragit EPO with hydroxypropyl methylcellulose E50 [EuD-HPMC]) as excipient, and surface tracking of Cur ASDs was mainly addressed.
Na, Fan, Tong, Lu, Jing, Li
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Alternative Solvent-Free Preparation Methods for Felodipine Surface Solid Dispersions
Drug Development and Industrial Pharmacy, 1998Surface solid dispersions were prepared via physical mixture and were either heated in a vacuum dryer or in a microwave oven for different periods of time. The physical state of felodipine in solid dispersions was studied using differential scanning calorimetry and x-ray powder diffractometry.
J, Kerc, S, Srcic, B, Kofler
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Drug Development and Industrial Pharmacy, 1988
AbstractBy grinding, chloramphenicol stearate Form III turns into Form I: then this form tends to become amorphous. So the grinding of both forms produces a “physically activated” form (FI*) with low crystallinity degree and high CAP availability.
FORNI, Flavio +4 more
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AbstractBy grinding, chloramphenicol stearate Form III turns into Form I: then this form tends to become amorphous. So the grinding of both forms produces a “physically activated” form (FI*) with low crystallinity degree and high CAP availability.
FORNI, Flavio +4 more
openaire +1 more source