Results 1 to 10 of about 460,902 (390)

Face classification using electronic synapses

open access: yesNature Communications, 2017
Conventional hardware platforms consume huge amount of energy for cognitive learning due to the data movement between the processor and the off-chip memory.
Hua-Qiang Wu   +2 more
exaly   +2 more sources

Electrical synapses and their functional interactions with chemical synapses [PDF]

open access: yesNature Reviews Neuroscience, 2014
Brain function relies on the ability of neurons to communicate with each other. Interneuronal communication primarily takes place at synapses, where information from one neuron is rapidly conveyed to a second neuron. There are two main modalities of synaptic transmission: chemical and electrical. Far from functioning independently and serving unrelated
Alberto E Pereda
exaly   +4 more sources

Huntingtin and the Synapse [PDF]

open access: yesFrontiers in Cellular Neuroscience, 2021
Huntington disease (HD) is a monogenic disease that results in a combination of motor, psychiatric and cognitive symptoms. HD is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene, which results in the production of a pathogenic mutant HTT protein (mHTT).
Barron, Jessica C.   +2 more
openaire   +5 more sources

The History of the Synapse [PDF]

open access: yesThe Anatomical Record, 2020
ABSTRACTWhy did I choose this particular topic for my lecture rather than the history of neuroscience or the history of the neuron? Simply because I believe that every disciple has the obligation to pay homage to their mentors once in their lifetime. My formation as a neuroscientist involved three such mentors spanned across three countries.
Constantino Sotelo, Constantino Sotelo
openaire   +3 more sources

Developmental Changes of Human Neural Progenitor Cells Grafted into the Ventricular System and Prefrontal Cortex of Mouse Brain in Utero

open access: yesCells, 2023
The transplantation of neural progenitors into a host brain represents a useful tool to evaluate the involvement of cell-autonomous processes and host local cues in the regulation of neuronal differentiation during the development of the mammalian brain.
Maria Llach Pou   +6 more
doaj   +1 more source

Functional maturation of human iPSC-derived pyramidal neurons in vivo is dependent on proximity with the host tissue

open access: yesFrontiers in Cellular Neuroscience, 2023
Human induced pluripotent stem cells (hiPSCs) have been used extensively in vitro to model early events in neurodevelopment. Because of a number of shortcomings, previous work has established a potential to use these cells in vivo after transplantation ...
Célia Raïs   +11 more
doaj   +1 more source

Pathological and Synaptic Morphological Changes of the Olfactory Bulb in APP/PS1 Model Mice at Different Ages and the Intervention Effect of Memantine

open access: yesShiyan dongwu yu bijiao yixue, 2022
Objective To compare and explore the histopathological and ultrastructural characteristics of the olfactory bulb in 6- and 12-month-old APP/PS1 double-transgenic mice and their spatial learning and memory ability, as well as the effects of memantine ...
LIU Jiani   +6 more
doaj   +1 more source

Systemic Inflammation Accelerates Changes in Microglial and Synaptic Markers in an Experimental Model of Chronic Neurodegeneration

open access: yesFrontiers in Neuroscience, 2022
Bacterial infections are a common cause of morbidity and mortality in the elderly, and particularly in individuals with a neurodegenerative disease. Experimental models of neurodegeneration have shown that LPS-induced systemic inflammation increases ...
Joe K. Chouhan   +3 more
doaj   +1 more source

The Dynamic Synapse [PDF]

open access: yesNeuron, 2013
The constant dynamic movement of synapses and their components has emerged in the last decades as a key feature of synaptic transmission and its plasticity. Intramolecular protein movements drive conformation changes important to transduce transmitter binding into signaling. Constant cytoskeletal rearrangements power synapse shape movements.
Daniel Choquet, Antoine Triller
openaire   +3 more sources

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