Results 1 to 10 of about 186,860 (175)

Developmental Changes of Human Neural Progenitor Cells Grafted into the Ventricular System and Prefrontal Cortex of Mouse Brain in Utero

open access: yesCells, 2023
The transplantation of neural progenitors into a host brain represents a useful tool to evaluate the involvement of cell-autonomous processes and host local cues in the regulation of neuronal differentiation during the development of the mammalian brain.
Maria Llach Pou   +6 more
doaj   +1 more source

Functional maturation of human iPSC-derived pyramidal neurons in vivo is dependent on proximity with the host tissue

open access: yesFrontiers in Cellular Neuroscience, 2023
Human induced pluripotent stem cells (hiPSCs) have been used extensively in vitro to model early events in neurodevelopment. Because of a number of shortcomings, previous work has established a potential to use these cells in vivo after transplantation ...
Célia Raïs   +11 more
doaj   +1 more source

Drosophila gustatory projections are segregated by taste modality and connectivity

open access: yeseLife, 2022
Gustatory sensory neurons detect caloric and harmful compounds in potential food and convey this information to the brain to inform feeding decisions. To examine the signals that gustatory neurons transmit and receive, we reconstructed gustatory axons ...
Stefanie Engert   +3 more
doaj   +1 more source

The role of peptidyl-prolyl isomerase Pin1 in neuronal signaling in epilepsy

open access: yesFrontiers in Molecular Neuroscience, 2022
Epilepsy is a common symptom of many neurological disorders and can lead to neuronal damage that plays a major role in seizure-related disability.
Yuwen Chen   +10 more
doaj   +1 more source

Pathological and Synaptic Morphological Changes of the Olfactory Bulb in APP/PS1 Model Mice at Different Ages and the Intervention Effect of Memantine

open access: yesShiyan dongwu yu bijiao yixue, 2022
Objective To compare and explore the histopathological and ultrastructural characteristics of the olfactory bulb in 6- and 12-month-old APP/PS1 double-transgenic mice and their spatial learning and memory ability, as well as the effects of memantine ...
LIU Jiani   +6 more
doaj   +1 more source

Noise-modulated multistable synapses in a Wilson-Cowan-based model of plasticity

open access: yesFrontiers in Computational Neuroscience, 2023
Frequency-dependent plasticity refers to changes in synaptic strength in response to different stimulation frequencies. Resonance is a factor known to be of importance in such frequency dependence, however, the role of neural noise in the process remains
Caroline A. Lea-Carnall   +2 more
doaj   +1 more source

The implication of a diversity of non-neuronal cells in disorders affecting brain networks

open access: yesFrontiers in Cellular Neuroscience, 2022
In the central nervous system (CNS) neurons are classically considered the functional unit of the brain. Analysis of the physical connections and co-activation of neurons, referred to as structural and functional connectivity, respectively, is a metric ...
Micaël Carrier   +11 more
doaj   +1 more source

Rostral and caudal basolateral amygdala engage distinct circuits in the prelimbic and infralimbic prefrontal cortex

open access: yeseLife, 2022
Connections from the basolateral amygdala (BLA) to medial prefrontal cortex (PFC) regulate memory and emotion and become disrupted in neuropsychiatric disorders.
Kasra Manoocheri, Adam G Carter
doaj   +1 more source

Heterosynaptic Plasticity and the Experience-Dependent Refinement of Developing Neuronal Circuits

open access: yesFrontiers in Neural Circuits, 2021
Neurons remodel the structure and strength of their synapses during critical periods of development in order to optimize both perception and cognition.
Kyle R. Jenks   +4 more
doaj   +1 more source

Exact mean-field theory explains the dual role of electrical synapses in collective synchronization [PDF]

open access: yesPhys. Rev. Lett. 125, 248101 (2020), 2020
Electrical synapses play a major role in setting up neuronal synchronization, but the precise mechanisms whereby these synapses contribute to synchrony are subtle and remain elusive. To investigate these mechanisms mean-field theories for quadratic integrate-and-fire neurons with electrical synapses have been recently put forward.
arxiv   +1 more source

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