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Cells, 2023 The transplantation of neural progenitors into a host brain represents a useful tool to evaluate the involvement of cell-autonomous processes and host local cues in the regulation of neuronal differentiation during the development of the mammalian brain.
Maria Llach Pou +6 more
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Frontiers in Cellular Neuroscience, 2023 Human induced pluripotent stem cells (hiPSCs) have been used extensively in vitro to model early events in neurodevelopment. Because of a number of shortcomings, previous work has established a potential to use these cells in vivo after transplantation ...
Célia Raïs +11 more
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The role of peptidyl-prolyl isomerase Pin1 in neuronal signaling in epilepsy
Frontiers in Molecular Neuroscience, 2022 Epilepsy is a common symptom of many neurological disorders and can lead to neuronal damage that plays a major role in seizure-related disability.
Yuwen Chen +10 more
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Noise-modulated multistable synapses in a Wilson-Cowan-based model of plasticity
Frontiers in Computational Neuroscience, 2023 Frequency-dependent plasticity refers to changes in synaptic strength in response to different stimulation frequencies. Resonance is a factor known to be of importance in such frequency dependence, however, the role of neural noise in the process remains
Caroline A. Lea-Carnall +2 more
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Cells, 2022 Even in the era of effective antiretroviral therapies, people living with Human Immunodeficiency Virus (HIV) are burdened with debilitating neurological dysfunction, such as HIV-associated neurocognitive disorders (HAND) and HIV-associated pain, for ...
Zachary Watson, Shao-Jun Tang
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Shiyan dongwu yu bijiao yixue, 2022 Objective To compare and explore the histopathological and ultrastructural characteristics of the olfactory bulb in 6- and 12-month-old APP/PS1 double-transgenic mice and their spatial learning and memory ability, as well as the effects of memantine ...
LIU Jiani +6 more
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Clusters of synaptic inputs on dendrites of layer 5 pyramidal cells in mouse visual cortex
eLife, 2016 The spatial organization of synaptic inputs on the dendritic tree of cortical neurons plays a major role for dendritic integration and neural computations, yet, remarkably little is known about it.
Onur Gökçe +2 more
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Cells, 2021 The extracellular matrix (ECM) plays a key role in synaptogenesis and the regulation of synaptic functions in the central nervous system. Recent studies revealed that in addition to dopaminergic and serotoninergic neuromodulatory systems, microglia also ...
Luisa Strackeljan +6 more
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Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength [PDF]
, 2013 During the first postnatal month glutamatergic synapses between layer 5 pyramidal cells in the rodent neocortex switch from an immature state exhibiting high probability of neurotransmitter release, large unitary amplitude and synaptic depression to a ...
Dunwiddie TV +3 more
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Frontiers in Neuroscience, 2022 Bacterial infections are a common cause of morbidity and mortality in the elderly, and particularly in individuals with a neurodegenerative disease. Experimental models of neurodegeneration have shown that LPS-induced systemic inflammation increases ...
Joe K. Chouhan +3 more
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