Results 1 to 10 of about 352,422 (329)

Developmental Changes of Human Neural Progenitor Cells Grafted into the Ventricular System and Prefrontal Cortex of Mouse Brain in Utero

Cells, 2023
The transplantation of neural progenitors into a host brain represents a useful tool to evaluate the involvement of cell-autonomous processes and host local cues in the regulation of neuronal differentiation during the development of the mammalian brain.
Maria Llach Pou, Camille Thiberge, Michiel Van der Zwan, Annousha Devi Govindan, Stéphanie Pons, Uwe Maskos, Isabelle Cloëz-Tayarani   +6 more
doaj   +1 more source

Functional maturation of human iPSC-derived pyramidal neurons in vivo is dependent on proximity with the host tissue

Frontiers in Cellular Neuroscience, 2023
Human induced pluripotent stem cells (hiPSCs) have been used extensively in vitro to model early events in neurodevelopment. Because of a number of shortcomings, previous work has established a potential to use these cells in vivo after transplantation ...
Célia Raïs, Célia Raïs, Daniela Gaspar Santos, Daniela Gaspar Santos, Giulia Sansone, Stéphane Blanchard, Jean-Pierre Bourgeois, Bernd Jagla, Baptiste Saudemont, Laurène Schlick, Stéphanie Pons, Uwe Maskos   +11 more
doaj   +1 more source

Neuron Class and Target Variability in the Three-Dimensional Localization of SK2 Channels in Hippocampal Neurons as Detected by Immunogold FIB-SEM

Frontiers in Neuroanatomy, 2021
Small-conductance calcium-activated potassium (SK) channels are crucial for learning and memory. However, many aspects of their spatial organization in neurons are still unknown.
Rafael Luján, Angel Merchán-Pérez, Joaquim Soriano, Alejandro Martín-Belmonte, Carolina Aguado, Rocío Alfaro-Ruiz, Ana Esther Moreno-Martínez, Javier DeFelipe, Javier DeFelipe   +8 more
doaj   +1 more source

Erosion of Gene Co-expression Networks Reveal Deregulation of Immune System Processes in Late-Onset Alzheimer’s Disease

Frontiers in Neuroscience, 2020
We have applied a novel and integrative analysis framework for next-generation sequencing (NGS) data to 503 human subjects provided by the Religious Orders Study and Memory and Aging Project (ROSMAP) to examine changes in transcriptomic organization and ...
John Stephen Malamon, Andres Kriete
doaj   +1 more source

Exercise Intervention Promotes the Growth of Synapses and Regulates Neuroplasticity in Rats With Ischemic Stroke Through Exosomes

Frontiers in Neurology, 2021
Background: Stroke is the leading cause of death and disability. Exercise produces neuroprotection by improving neuroplasticity. Exercise can induce exosome production.
Chen Li, Changkai Ke, Yue Su, Chunxiao Wan   +3 more
doaj   +1 more source

Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling

Frontiers in Pharmacology, 2020
Purmorphamine (PUR), an agonist of the Smoothened (Smo) receptor, has been shown to function as a neuroprotectant in acute experimental ischemic stroke. Its role in hypoxic-ischemic (HI) brain injury in neonatal mice remains unknown.
Dexiang Liu, Xuemei Bai, Weiwei Ma, Weiwei Ma, Danqing Xin, Xili Chu, Hongtao Yuan, Jie Qiu, Jie Qiu, HongFei Ke, Sen Yin, Wenqiang Chen, Zhen Wang   +12 more
doaj   +1 more source

Clusters of synaptic inputs on dendrites of layer 5 pyramidal cells in mouse visual cortex

eLife, 2016
The spatial organization of synaptic inputs on the dendritic tree of cortical neurons plays a major role for dendritic integration and neural computations, yet, remarkably little is known about it.
Onur Gökçe, Tobias Bonhoeffer, Volker Scheuss   +2 more
doaj   +1 more source

Optimal Self-Induced Stochastic Resonance in Multiplex Neural Networks: Electrical vs. Chemical Synapses

Frontiers in Computational Neuroscience, 2020
Electrical and chemical synapses shape the dynamics of neural networks, and their functional roles in information processing have been a longstanding question in neurobiology.
Marius E. Yamakou, Marius E. Yamakou, Poul G. Hjorth, Erik A. Martens, Erik A. Martens, Erik A. Martens   +5 more
doaj   +1 more source

Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength [PDF]

, 2013
During the first postnatal month glutamatergic synapses between layer 5 pyramidal cells in the rodent neocortex switch from an immature state exhibiting high probability of neurotransmitter release, large unitary amplitude and synaptic depression to a ...
Dunwiddie TV, Magnus J. E. Richardson, Mark J. Wall, Michael I. Kerr   +3 more
core   +1 more source

Subcellular sorting of neuregulins controls the assembly of excitatory-inhibitory cortical circuits

eLife, 2020
The assembly of specific neuronal circuits relies on the expression of complementary molecular programs in presynaptic and postsynaptic neurons. In the cerebral cortex, the tyrosine kinase receptor ErbB4 is critical for the wiring of specific populations
David Exposito-Alonso, Catarina Osório, Clémence Bernard, Sandra Pascual-García, Isabel del Pino, Oscar Marín, Beatriz Rico   +6 more
doaj   +1 more source