Results 1 to 10 of about 466,973 (293)

Developmental Changes of Human Neural Progenitor Cells Grafted into the Ventricular System and Prefrontal Cortex of Mouse Brain in Utero

Cells, 2023
The transplantation of neural progenitors into a host brain represents a useful tool to evaluate the involvement of cell-autonomous processes and host local cues in the regulation of neuronal differentiation during the development of the mammalian brain.
Maria Llach Pou, Camille Thiberge, Michiel Van der Zwan, Annousha Devi Govindan, Stéphanie Pons, Uwe Maskos, Isabelle Cloëz-Tayarani   +6 more
doaj   +1 more source

Functional maturation of human iPSC-derived pyramidal neurons in vivo is dependent on proximity with the host tissue

Frontiers in Cellular Neuroscience, 2023
Human induced pluripotent stem cells (hiPSCs) have been used extensively in vitro to model early events in neurodevelopment. Because of a number of shortcomings, previous work has established a potential to use these cells in vivo after transplantation ...
Célia Raïs, Célia Raïs, Daniela Gaspar Santos, Daniela Gaspar Santos, Giulia Sansone, Stéphane Blanchard, Jean-Pierre Bourgeois, Bernd Jagla, Baptiste Saudemont, Laurène Schlick, Stéphanie Pons, Uwe Maskos   +11 more
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Pathological and Synaptic Morphological Changes of the Olfactory Bulb in APP/PS1 Model Mice at Different Ages and the Intervention Effect of Memantine

Shiyan dongwu yu bijiao yixue, 2022
Objective To compare and explore the histopathological and ultrastructural characteristics of the olfactory bulb in 6- and 12-month-old APP/PS1 double-transgenic mice and their spatial learning and memory ability, as well as the effects of memantine ...
LIU Jiani, LIU Jiangang, WEI Yun, LI Hao, LUO Zenggang, WANG Yi, LI Kun   +6 more
doaj   +1 more source

Systemic Inflammation Accelerates Changes in Microglial and Synaptic Markers in an Experimental Model of Chronic Neurodegeneration

Frontiers in Neuroscience, 2022
Bacterial infections are a common cause of morbidity and mortality in the elderly, and particularly in individuals with a neurodegenerative disease. Experimental models of neurodegeneration have shown that LPS-induced systemic inflammation increases ...
Joe K. Chouhan, Ursula Püntener, Steven G. Booth, Jessica L. Teeling   +3 more
doaj   +1 more source

Microglia Depletion-Induced Remodeling of Extracellular Matrix and Excitatory Synapses in the Hippocampus of Adult Mice

Cells, 2021
The extracellular matrix (ECM) plays a key role in synaptogenesis and the regulation of synaptic functions in the central nervous system. Recent studies revealed that in addition to dopaminergic and serotoninergic neuromodulatory systems, microglia also ...
Luisa Strackeljan, Ewa Baczynska, Carla Cangalaya, David Baidoe-Ansah, Jakub Wlodarczyk, Rahul Kaushik, Alexander Dityatev   +6 more
doaj   +1 more source

Rostral and caudal basolateral amygdala engage distinct circuits in the prelimbic and infralimbic prefrontal cortex

eLife, 2022
Connections from the basolateral amygdala (BLA) to medial prefrontal cortex (PFC) regulate memory and emotion and become disrupted in neuropsychiatric disorders.
Kasra Manoocheri, Adam G Carter
doaj   +1 more source

Interaction and Subcellular Association of PRRT1/SynDIG4 With AMPA Receptors

Frontiers in Synaptic Neuroscience, 2021
AMPA receptors (AMPAR) are organized into supramolecular complexes in association with other membrane proteins that provide exquisite regulation of their biophysical properties and subcellular trafficking.
Emily Eischen Martin, Erica Wleklinski, Hanh T. M. Hoang, Mohiuddin Ahmad   +3 more
doaj   +1 more source

The implication of a diversity of non-neuronal cells in disorders affecting brain networks

Frontiers in Cellular Neuroscience, 2022
In the central nervous system (CNS) neurons are classically considered the functional unit of the brain. Analysis of the physical connections and co-activation of neurons, referred to as structural and functional connectivity, respectively, is a metric ...
Micaël Carrier, Micaël Carrier, Kira Dolhan, Kira Dolhan, Bianca Caroline Bobotis, Michèle Desjardins, Michèle Desjardins, Marie-Ève Tremblay, Marie-Ève Tremblay, Marie-Ève Tremblay, Marie-Ève Tremblay, Marie-Ève Tremblay   +11 more
doaj   +1 more source

Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulated in Exercise in a Mouse Model of Parkinson’s Disease

Frontiers in Aging Neuroscience, 2022
BackgroundExercise plays an essential role in improving motor symptoms in Parkinson’s disease (PD), but the underlying mechanism in the central nervous system remains unclear.MethodsMotor ability was observed after 12-week treadmill exercise on a 1 ...
Weifang Tong, Weifang Tong, Kunshan Zhang, Hongkai Yao, Lixi Li, Yong Hu, Jingxing Zhang, Yunping Song, Qiang Guan, Siguang Li, Yi E. Sun, Lingjing Jin, Lingjing Jin   +12 more
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Neurofilament Levels in Dendritic Spines Associate with Synaptic Status

Cells, 2023
Neurofilaments are one of the main cytoskeletal components in neurons; they can be found in the form of oligomers at pre- and postsynapses. How their presence is regulated at the postsynapse remains largely unclear.
Clara-Marie Gürth, Maria Augusta do Rego Barros Fernandes Lima, Victor Macarrón Palacios, Angel Rafael Cereceda Delgado, Jasmine Hubrich, Elisa D’Este   +5 more
doaj   +1 more source