Results 1 to 10 of about 445,271 (401)
Optimal learning rules for discrete synapses [PDF]
, 2008 There is evidence that biological synapses have a limited number of discrete weight states. Memory storage with such synapses behaves quite differently from synapses with unbounded, continuous weights, as old memories are automatically overwritten by new
Barrett, Adam B, van Rossum, M C W
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Huntingtin and the Synapse [PDF]
Frontiers in Cellular Neuroscience, 2021 Huntington disease (HD) is a monogenic disease that results in a combination of motor, psychiatric and cognitive symptoms. HD is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene, which results in the production of a pathogenic mutant HTT protein (mHTT).
Barron, Jessica C. +2 more
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The History of the Synapse [PDF]
The Anatomical Record, 2020 ABSTRACTWhy did I choose this particular topic for my lecture rather than the history of neuroscience or the history of the neuron? Simply because I believe that every disciple has the obligation to pay homage to their mentors once in their lifetime. My formation as a neuroscientist involved three such mentors spanned across three countries.
Constantino Sotelo, Constantino Sotelo
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Neuron, 2013 The constant dynamic movement of synapses and their components has emerged in the last decades as a key feature of synaptic transmission and its plasticity. Intramolecular protein movements drive conformation changes important to transduce transmitter binding into signaling. Constant cytoskeletal rearrangements power synapse shape movements.
Daniel Choquet, Antoine Triller
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Cell, 2004 The transmission of information across neuronal synapses is an energetically taxing business. Sheng and colleagues monitored the localization of mitochondria following different levels of synaptic activation and discovered that these organelles change their distribution in interesting ways, stalling near synapses when neurons are activated and ...
Schuman, E., Chan, D.
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Synapses immunologiques et synapses neuronales [PDF]
médecine/sciences, 2003 Les systemes nerveux et immunitaire ont en commun de constituer dans l’organisme des reseaux complexes de cellules en interaction. Dans ces reseaux transitent en permanence d’enormes quantites d’informations, codees de facon tres differente dans les deux cas. Ces informations doivent en particulier circuler de cellule en cellule.
Trautmann, Alain +3 more
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The Immunological Synapse [PDF]
Cancer Immunology Research, 2003 AbstractThe molecular interactions underlying regulation of the immune response take place in a nanoscale gap between T cells and antigen-presenting cells, termed the immunological synapse. If these interactions are regulated appropriately, the host is defended against a wide range of pathogens and deranged host cells.
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Evidence against AMPA receptor-lacking glutamatergic synapses in the superficial dorsal horn of the rat spinal cord [PDF]
, 2009 Pure NMDA receptor (NMDAr)-mediated EPSCs, thought to correspond to "silent" glutamatergic synapses that lack AMPA receptors (AMPArs), have been observed in superficial spinal dorsal horn of neonatal but not adult rats.
Hughes, D.I. +6 more
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Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength [PDF]
, 2013 During the first postnatal month glutamatergic synapses between layer 5 pyramidal cells in the rodent neocortex switch from an immature state exhibiting high probability of neurotransmitter release, large unitary amplitude and synaptic depression to a ...
Dunwiddie TV +3 more
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Electrochemistry at the Synapse [PDF]
Annual Review of Analytical Chemistry, 2019 Electrochemical measurements of neurotransmitters provide insight into the dynamics of neurotransmission. In this review, we describe the development of electrochemical measurements of neurotransmitters and how they started with extrasynaptic measurements but now are pushing toward synaptic measurements.
Jason R. Borgus +3 more
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