Results 51 to 60 of about 460,902 (390)
Biology, 2015 A key event in Alzheimer’s disease (AD) is the production of amyloid-β (Aβ) peptides and the loss of synapses. In cultured neurons Aβ triggered synapse damage as measured by the loss of synaptic proteins. α-synuclein (αSN), aggregates of which accumulate
Clive Bate, Alun Williams
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eLife, 2023 The joint storage and reciprocal retrieval of learnt associated signals are presumably encoded by associative memory cells. In the accumulation and enrichment of memory contents in lifespan, a signal often becomes a core signal associatively shared for ...
Yang Xu +4 more
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A brainwide atlas of synapses across the mouse life span
Science, 2020 Brain synapses through the life span Excitatory synapses connect neurons in the brain to build the circuits that enable behavior. Cizeron et al. surveyed synapses in the mouse brain from birth to old age and present the data as a community resource, the ...
Mélissa Cizeron +6 more
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Analytical and Bioanalytical Chemistry, 2006 Large-scale phosphoproteome analysis on synaptosome and preparation of post-synaptic density (PSD) were investigated. It was found that protein phosphor is a common event in the synapse, which is consistent with the presence of diverse classes of kinases and phosphatases in the synapse.
openaire +4 more sources
Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4. [PDF]
, 2014 Lrp4, the muscle receptor for neuronal Agrin, is expressed in the hippocampus and areas involved in cognition. The function of Lrp4 in the brain, however, is unknown, as Lrp4-/- mice fail to form neuromuscular synapses and die at birth.
Burden, Steven J +2 more
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Ectopic localization of neural crest cells: etiological factor of scoliosis
Хирургия позвоночника, 2015 Objective. To identify cell phenotypes in vertebral body growth plates from patients with idiopathic scoliosis. Material and Methods. Cells were isolated from vertebral body growth plates both on convex and concave sides of the de- formity in 50 ...
Alla M. Zaidman +6 more
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Storage Capacity of Extremely Diluted Hopfield Model
, 2004 The storage capacity of the extremely diluted Hopfield Model is studied by using Monte Carlo techniques. In this work, instead of diluting the synapses according to a given distribution, the dilution of the synapses is obtained systematically by ...
BURCU AKCAN +2 more
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State based model of long-term potentiation and synaptic tagging and capture [PDF]
, 2009 Recent data indicate that plasticity protocols have not only synapse-specific but also more widespread effects. In particular, in synaptic tagging and capture (STC), tagged synapses can capture plasticity-related proteins, synthesized in response to ...
A Govindarajan +50 more
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iScienceSummary: Retinal ganglion cells (RGCs) summate inputs and forward a spike train code to the brain in the form of either maintained spiking (sustained) or a quickly decaying brief spike burst (transient).
Gergely Szarka +8 more
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Heterosynaptic Plasticity and the Experience-Dependent Refinement of Developing Neuronal Circuits
Frontiers in Neural Circuits, 2021 Neurons remodel the structure and strength of their synapses during critical periods of development in order to optimize both perception and cognition.
Kyle R. Jenks +4 more
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