Results 11 to 20 of about 530,363 (319)

Treadmill Exercise Prevents Decline in Spatial Learning and Memory in 3×Tg-AD Mice through Enhancement of Structural Synaptic Plasticity of the Hippocampus and Prefrontal Cortex

Cells, 2022
Alzheimer’s disease (AD) is characterized by deficits in learning and memory. A pathological feature of AD is the alterations in the number and size of synapses, axon length, dendritic complexity, and dendritic spine numbers in the hippocampus and ...
Lianwei Mu, Jiajia Cai, Boya Gu, Laikang Yu, Cui Li, Qing-Song Liu, Li Zhao   +6 more
doaj   +1 more source

Genetic Diagnosis Spectrum and Multigenic Burden of Exome-Level Rare Variants in a Childhood Epilepsy Cohort

Frontiers in Genetics, 2021
Childhood epilepsy is a considerably heterogeneous neurological condition with a high worldwide incidence. Genetic diagnosis of childhood epilepsy provides the most accurate pathogenetic evidence; however, a large proportion of highly suspected cases ...
Ruen Yao, Yunqing Zhou, Jie Tang, Niu Li, Tingting Yu, Yingzhong He, Cuijin Wang, Jiwen Wang, Jian Wang   +8 more
doaj   +1 more source

Extrasynaptic δ-subunit containing GABAA receptors [PDF]

Journal of Integrative Neuroscience, 2021
γ-Aminobutyric acid type A receptors (GABAARs) are GABA gated heteropentameric chloride channels responsible for the adult brain’s primary inhibition.
Ayla Arslan
doaj   +1 more source

MAGUKs, Synaptic Development, and Synaptic Plasticity [PDF]

The Neuroscientist, 2011
MAGUKs are proteins that act as key scaffolds in surface complexes containing receptors, adhesion proteins, and various signaling molecules. These complexes evolved prior to the appearance of multicellular animals and play key roles in cell-cell intercommunication.
Chan-Ying, Zheng, Gail K, Seabold, Martin, Horak, Ronald S, Petralia   +3 more
openaire   +2 more sources

Regulation of NMDA Receptor Signaling at Single Synapses by Human Anti-NMDA Receptor Antibodies

Frontiers in Molecular Neuroscience, 2022
The NMDA receptor (NMDAR) subunit GluN1 is critical for receptor function and plays a pivotal role in synaptic plasticity. Mounting evidence has shown that pathogenic autoantibody targeting of the GluN1 subunit of NMDARs, as in anti-NMDAR encephalitis ...
Charles A. Dean, Sarah R. Metzbower, Scott K. Dessain, Thomas A. Blanpied, David R. Benavides   +4 more
doaj   +1 more source

Amitriptyline Decreases GABAergic Transmission in Basal Forebrain Neurons Using an Optogenetic Model of Aging

Frontiers in Aging Neuroscience, 2021
The antidepressant drug amitriptyline is used in the treatment of clinical depression and a variety of neurological conditions such as anxiety, neuropathic pain disorders and migraine.
Eunyoung Bang, Angelika Tobery, Karienn S. Montgomery, Annette S. Fincher, David J. Earnest, David A. Murchison, William H. Griffith   +6 more
doaj   +1 more source

Parvalbumin interneurons provide spillover to newborn and mature dentate granule cells

eLife, 2020
Parvalbumin-expressing interneurons (PVs) in the dentate gyrus provide activity-dependent regulation of adult neurogenesis as well as maintain inhibitory control of mature neurons.
Ryan J Vaden, Jose Carlos Gonzalez, Ming-Chi Tsai, Anastasia J Niver, Allison R Fusilier, Chelsea M Griffith, Richard H Kramer, Jacques I Wadiche, Linda Overstreet-Wadiche   +8 more
doaj   +1 more source

Trans-synaptic assemblies link synaptic vesicles and neuroreceptors [PDF]

Science Advances, 2021
Tripartite trans-synaptic assemblies directly link pre- and postsynaptic complexes crucial for synaptic transmission.
Antonio Martinez-Sanchez, Ulrike Laugks, Zdravko Kochovski, Christos Papantoniou, Luca Zinzula, Wolfgang Baumeister, Vladan Lučić   +6 more
openaire   +6 more sources

Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit

Frontiers in Synaptic Neuroscience, 2016
The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories.
Luke Yuri Prince, Travis J Bacon, Cezar M. Tigaret, Jack R Mellor   +3 more
doaj   +1 more source

MSK1 regulates homeostatic and experience-dependent synaptic plasticity [PDF]

, 2012
The ability of neurons to modulate synaptic strength underpins synaptic plasticity, learning and memory, and adaptation to sensory experience. Despite the importance of synaptic adaptation in directing, reinforcing, and revising the behavioral response ...
Frenguelli, BrunoG., Corrêa, SAL, McKenzie, Colin, Palygin, O, Palygin, Oleg, Martin, KJ, Arthur, J.S., McKelvey, Kim, Hunter, CJ, Morris, R. G. M. (Richard G. M.), Morris, R.G., Morris, RGM, McKenzie, C, Hunter, Christopher J., Wauters, Sandrine C., Pankratov, Yuriy, Hunter, C.J., Wauters, S.C., Wauters, SC, Wauters, Sandrine, Martin, K.J., Arthur, J.Simon C.; id_orcid, Palygin, O., Frenguelli, BG, Corrêa, Sonia A.L., Corrêa, Sônia A. L., Arthur, J. Simon C., Frenguelli, Bruno G., Morris, Richard G. M., Frenguelli, B.G., Pankratov, Y., Martin, Kirsty J., McKelvey, Kim M. (Kim Martin), McKenzie, C., Arthur, JSC, McKelvey, K., Pankratov, Y, McKelvey, K   +37 more
core   +1 more source