Results 21 to 30 of about 530,363 (319)
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1991 ABSTRACT:Synapse formation is a complex, incompletely understood process that has received only limited investigation in man despite the importance of synaptic dysfunction in common disorders such as epilepsy and mental retardation. This review explores synaptic differentiation, focussing on the morphologic maturation of synapses. Since differentiation
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Pre-synaptic terminal dynamics in the hippocampus [PDF]
, 2003 This thesis work dealt with the study of synaptic plasticity in the adult brain. This is an area of intensive investigation because instability of synapses is believed to underlie cognitive processes like learning and memory in the CNS, and adaptation ...
De Paola, Vincenzo
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Frontiers in Cellular Neuroscience, 2021 Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are characterized by degeneration of upper and lower motor neurons and neurons of the prefrontal cortex.
Iris-Stefania Pasniceanu +4 more
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Network self-organization explains the statistics and dynamics of synaptic connection strengths in cortex [PDF]
, 2013 The information processing abilities of neural circuits arise from their synaptic connection patterns. Understanding the laws governing these connectivity patterns is essential for understanding brain function.
Jochen Triesch (106561) +13 more
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WormBook, 2006 C. elegans has emerged as a powerful genetic model organism in which to study synaptic function. Most synaptic proteins in the C. elegans genome are highly conserved and mutants can be readily generated by forward and reverse genetics. Most C. elegans synaptic protein mutants are viable affording an opportunity to study the functional consequences in ...
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eLife, 2022 Anatomical and physiological compartmentalization of neurons is a mechanism to increase the computational capacity of a circuit, and a major question is what role axonal compartmentalization plays.
Aaron Stahl +10 more
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Learning to Discriminate Through Long-Term Changes of Dynamical Synaptic Transmission [PDF]
, 2008 Short-term synaptic plasticity is modulated by long-term synaptic changes. There is, however, no general agreement on the computational role of this interaction.
Gundlfinger, Anja +10 more
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Locally-Induced CaMKII Translocation Requires Nucleotide Binding
Frontiers in Synaptic Neuroscience, 2020 Calcium-calmodulin-dependent protein kinase (CaMKII) is a molecule involved in several cell processes including plasticity related to learning and memory. Activation of NMDA-type glutamate receptors results in translocation of CaMKII to synapses. However,
Zachary T. Fitzgerald +1 more
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The role of synaptic ion channels in synaptic plasticity [PDF]
EMBO reports, 2006 The nervous system receives a large amount of information about the environment through elaborate sensory routes. Processing and integration of these wide‐ranging inputs often results in long‐term behavioural alterations as a result of past experiences.
Giannis, Voglis, Nektarios, Tavernarakis
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Neuromuscular synaptic function in mice lacking major subsets of gangliosides [PDF]
, 2008 Gangliosides are a family of sialylated glycosphingolipids enriched in the outer leaflet of neuronal membranes, in particular at synapses. Therefore, they have been hypothesized to play a functional role in synaptic transmission.
Furukawa, K. +12 more
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