Results 51 to 60 of about 530,363 (319)

Regulation of synaptic connectivity: levels of fasciclin II influence synaptic growth in the Drosophila CNS [PDF]

, 2002
Much of our understanding of synaptogenesis comes from studies that deal with the development of the neuromuscular junction (NMJ). Although well studied, it is not clear how far the NMJ represents an adequate model for the formation of synapses within ...
Baines, Richard A.; id_orcid, Baines, Richard A., Salvaterra, Paul M., Thompson, Annemarie, Bate, Michael, Seugnet, Laurent   +5 more
core  

Entorhinal denervation induces homeostatic synaptic scaling of excitatory postsynapses of dentate granule cells in mouse organotypic slice cultures

, 2012
Denervation-induced changes in excitatory synaptic strength were studied following entorhinal deafferentation of hippocampal granule cells in mature (≥3 weeks old) mouse organotypic entorhino-hippocampal slice cultures.
Roeper, Jochen, Roeper Jochen, Winkels, Raphael, Denise Becker (179935), Thomas Deller, Thomas Deller (179947), Denise Becker, Jedlička, Peter, Becker Denise, Jochen Roeper, Jedlicka Peter, Winkels Raphael, Andreas Vlachos (47497), Vlachos Andreas, Vlachos, Andreas, Andreas Vlachos, Peter Jedlicka, Jochen Roeper (179944), Becker, Denise, Peter Jedlicka (179938), Raphael Winkels (179941), Deller Thomas, Deller, Thomas, Raphael Winkels   +23 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Spike train auto-structure impacts post-synaptic firing and timing-based plasticity

, 2011
Cortical neurons are typically driven by several thousand synapses. The precise spatiotemporal pattern formed by these inputs can modulate the response of a post-synaptic cell.
Pipa, Gordon, Castellano, Marta, Vicente, Raul, Gordon Pipa, Bertram Scheller, Scheller, Bertram, Marta Castellano, Raul Vicente   +7 more
core   +1 more source

Following the genes: a framework for animal modeling of psychiatric disorders

BMC Biology, 2011
The number of individual cases of psychiatric disorders that can be ascribed to identified, rare, single mutations is increasing with great rapidity. Such mutations can be recapitulated in mice to generate animal models with direct etiological validity ...
Sawa Akira, Moghaddam Bita, Huang Z Josh, Mitchell Kevin J   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Synaptic shot noise and conductance fluctuations affect the membrane voltage with equal significance [PDF]

, 2005
The subthresholdmembranevoltage of a neuron in active cortical tissue is a fluctuating quantity with a distribution that reflects the firing statistics of the presynaptic population.
Wulfram Gerstner, Richardson, Magnus J. E., Richardson, M. J. E., Gerstner, W., Magnus J. E. Richardson, Gerstner, Wulfram   +5 more
core   +1 more source

Optimizing electrochemical and ferroelectric synaptic devices: from material selection to performance tuning

Neuromorphic Computing and Engineering
Neuromorphic hardware systems emulate the parallel neural networks of the human brain, and synaptic weight storage elements are crucial for enabling energy-efficient information processing.
Eunjin Kim, Seonuk Jeon, Hyoungjin Park, Jiae Jeong, Hyeonsik Choi, Yunsur Kim, Jihyun Kim, Seokjae Lim, Kibong Moon, Jiyong Woo   +9 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity [PDF]

, 2013
miR-132 and miR-212 are two closely related miRNAs encoded in the same intron of a small non-coding gene, which have been suggested to play roles in both immune and neuronal function.
Mistry, Rajen B., McKenzie, Colin, Palygin, O, Palygin, Oleg, Hutvagner Gyorgy, Remenyi Judit, Mistry Rajen B., Remenyi, J, Yuriy Pankratov, Pankratov Yuriy, Mirjam W M van den Bosch, McKenzie, C, Andrew Macdonald, Frenguelli Bruno G., Hutvagner, G, van den Bosch, Mirjam W. M., Pankratov, Yuriy, van den Bosch, MWM, Mistry, RB, Gyorgy Hutvagner, Judit Remenyi, Arthur J. Simon C., Macdonald, Andrew, Macdonald, A, Colin McKenzie, Frenguelli, BG, Remenyi, Judit, Hutvagner, Gyorgy, Arthur, J. Simon C., Frenguelli, Bruno G., Macdonald Andrew, van den Bosch Mirjam W. M., Rajen B Mistry, Oleg Palygin, Bruno G Frenguelli, Palygin Oleg, Arthur, J. Simon C.; id_orcid, J Simon C Arthur, Arthur, JSC, Pankratov, Y, McKenzie Colin   +40 more
core   +1 more source