Results 1 to 10 of about 733,414 (331)

Network self-organization explains the statistics and dynamics of synaptic connection strengths in cortex [PDF]

, 2013
The information processing abilities of neural circuits arise from their synaptic connection patterns. Understanding the laws governing these connectivity patterns is essential for understanding brain function.
Dimitrakakis, Christos, Triesch, Jochen, Zheng, Pengsheng   +2 more
core   +18 more sources

Sustained postsynaptic kainate receptor activation downregulates AMPA receptor surface expression and induces hippocampal LTD

iScience, 2021
Summary: It is well established that long-term depression (LTD) can be initiated by either NMDA or mGluR activation. Here we report that sustained activation of GluK2 subunit-containing kainate receptors (KARs) leads to α-amino-3-hydroxy-5-methyl-4 ...
Jithin D. Nair, Ellen Braksator, Busra P. Yucel, Alexandra Fletcher-Jones, Richard Seager, Jack R. Mellor, Zafar I. Bashir, Kevin A. Wilkinson, Jeremy M. Henley   +8 more
doaj   +1 more source

GluK2 Q/R editing regulates kainate receptor signaling and long-term potentiation of AMPA receptors

iScience, 2023
Summary: Q/R editing of the kainate receptor (KAR) subunit GluK2 radically alters recombinant KAR properties, but the effects on endogenous KARs in vivo remain largely unexplored.
Jithin D. Nair, Kevin A. Wilkinson, Busra P. Yucel, Christophe Mulle, Bryce Vissel, Jack Mellor, Jeremy M. Henley   +6 more
doaj   +1 more source

Reduction in the activity of VTA/SNc dopaminergic neurons underlies aging-related decline in novelty seeking

Communications Biology, 2023
Curiosity, or novelty seeking, is a fundamental mechanism motivating animals to explore and exploit environments to improve survival, and is also positively associated with cognitive, intrapersonal and interpersonal well-being in humans.
Qiang Shan, Ye Tian, Hang Chen, Xiaoli Lin, Yao Tian   +4 more
doaj   +1 more source

Changes in pallidal neural activity following long-term symptom improvement from botulinum toxin treatment in DYT6 dystonia: a case report

Journal of Medical Case Reports, 2022
Background The globus pallidus internus is the main target for the treatment of dystonia by deep brain stimulation. Unfortunately, for some genetic etiologies, the therapeutic outcome of dystonia is less predictable.
Andrea Giorni, Terry Coyne, Peter A. Silburn, George D. Mellick, Pankaj Sah, François Windels   +5 more
doaj   +1 more source

Neurotrophic effects of Botulinum neurotoxin type A in hippocampal neurons involve activation of Rac1 by the non-catalytic heavy chain (HCC/A)

IBRO Neuroscience Reports, 2021
Botulinum neurotoxins (BoNTs) are extremely potent naturally occurring poisons that act by silencing neurotransmission. Intriguingly, in addition to preventing presynaptic vesicle fusion, BoNT serotype A (BoNT/A) can also promote axonal regeneration in ...
Luis Solabre Valois, Vanilla (Hua) Shi, Paul Bishop, Bangfu Zhu, Yasuko Nakamura, Kevin A. Wilkinson, Jeremy M. Henley   +6 more
doaj   +1 more source

LRP4 is required for the olfactory association task in the piriform cortex

Cell & Bioscience, 2022
Background Low-density lipoprotein receptor-related protein 4 (LRP4) plays a critical role in the central nervous system (CNS), including hippocampal synaptic plasticity, maintenance of excitatory synaptic transmission, fear regulation, as well as long ...
Min Yan, Mingtao Xiong, Yongqiang Wu, Dong Lin, Peng Chen, Jiang Chen, Ziyang Liu, Hang Zhang, Dongyan Ren, Erkang Fei, Xinsheng Lai, Suqi Zou, Shunqi Wang   +12 more
doaj   +1 more source

Impaired synaptic incorporation of AMPA receptors in a mouse model of fragile X syndrome

Frontiers in Molecular Neuroscience, 2023
Fragile X syndrome (FXS) is the most common monogenetic cause of inherited intellectual disability and autism in humans. One of the well-characterized molecular phenotypes of Fmr1 KO mice, a model of FXS, is increased translation of synaptic proteins ...
Magdalena Chojnacka, Anna Beroun, Marta Magnowska, Aleksandra Stawikowska, Dominik Cysewski, Jacek Milek, Magdalena Dziembowska, Bozena Kuzniewska   +7 more
doaj   +1 more source

Subcellular RNA-seq for the Analysis of the Dendritic and Somatic Transcriptomes of Single Neurons

Bio-Protocol, 2022
In neurons, local translation in dendritic and axonal compartments allows for the fast and on-demand modification of the local proteome. As the last few years have witnessed dramatic advancements in our appreciation of the brain’s neuronal diversity, it ...
Julio Perez, Erin Schuman
doaj   +1 more source

Metformin Ameliorates Lipopolysaccharide-Induced Depressive-Like Behaviors and Abnormal Glutamatergic Transmission

Biology, 2020
Metformin, a first-line drug for type 2 diabetes mellitus (T2DM), has been found to reduce depressive symptoms in patients with comorbid depression and other diseases.
Jiang Chen, Tian Zhou, A-Min Guo, Wen-Bing Chen, Dong Lin, Zi-Yang Liu, Er-Kang Fei   +6 more
doaj   +1 more source