Results 11 to 20 of about 724,295 (381)

Caspases in synaptic plasticity [PDF]

open access: yesMolecular Brain, 2012
Caspases are a family of cysteine proteases that play key roles in programmed cell death (apoptosis). Mounting evidence in recent years shows that caspases also have important non-apoptotic functions in multiple cellular processes, such as synaptic plasticity, dendritic development, learning and memory. In this article, we review the studies on the non-
Morgan Sheng, Zheng Li
openaire   +4 more sources

Neurotrophic effects of Botulinum neurotoxin type A in hippocampal neurons involve activation of Rac1 by the non-catalytic heavy chain (HCC/A)

open access: yesIBRO Neuroscience Reports, 2021
Botulinum neurotoxins (BoNTs) are extremely potent naturally occurring poisons that act by silencing neurotransmission. Intriguingly, in addition to preventing presynaptic vesicle fusion, BoNT serotype A (BoNT/A) can also promote axonal regeneration in ...
Luis Solabre Valois   +6 more
doaj   +1 more source

Synaptic plasticity as Bayesian inference [PDF]

open access: yesNature Neuroscience, 2021
Published in Nature Neuroscience: https://www.nature.com/articles/s41593-021-00809 ...
Laurence Aitchison   +8 more
openaire   +5 more sources

LRP4 is required for the olfactory association task in the piriform cortex

open access: yesCell & Bioscience, 2022
Background Low-density lipoprotein receptor-related protein 4 (LRP4) plays a critical role in the central nervous system (CNS), including hippocampal synaptic plasticity, maintenance of excitatory synaptic transmission, fear regulation, as well as long ...
Min Yan   +12 more
doaj   +1 more source

Metabotropic Regulation of Synaptic Plasticity [PDF]

open access: yesNeuroscience, 2021
descripción no proporcionada por ...
Fernández de Sevilla García, David   +3 more
openaire   +5 more sources

Impaired synaptic incorporation of AMPA receptors in a mouse model of fragile X syndrome

open access: yesFrontiers in Molecular Neuroscience, 2023
Fragile X syndrome (FXS) is the most common monogenetic cause of inherited intellectual disability and autism in humans. One of the well-characterized molecular phenotypes of Fmr1 KO mice, a model of FXS, is increased translation of synaptic proteins ...
Magdalena Chojnacka   +7 more
doaj   +1 more source

Burst-dependent synaptic plasticity can coordinate learning in hierarchical circuits

open access: yesNature Neuroscience, 2020
Synaptic plasticity is believed to be a key physiological mechanism for learning. It is well established that it depends on pre- and postsynaptic activity.
A. Payeur   +4 more
semanticscholar   +1 more source

Microglia regulate synaptic development and plasticity

open access: yesDevelopmental Neurobiology, 2021
Synapses are fundamental structures of neural circuits that transmit information between neurons. Thus, the process of neural circuit formation via proper synaptic connections shapes the basis of brain functions and animal behavior. Synapses continuously
Megumi Andoh, R. Koyama
semanticscholar   +1 more source

Subcellular RNA-seq for the Analysis of the Dendritic and Somatic Transcriptomes of Single Neurons

open access: yesBio-Protocol, 2022
In neurons, local translation in dendritic and axonal compartments allows for the fast and on-demand modification of the local proteome. As the last few years have witnessed dramatic advancements in our appreciation of the brain’s neuronal diversity, it ...
Julio Perez, Erin Schuman
doaj   +1 more source

Metformin Ameliorates Lipopolysaccharide-Induced Depressive-Like Behaviors and Abnormal Glutamatergic Transmission

open access: yesBiology, 2020
Metformin, a first-line drug for type 2 diabetes mellitus (T2DM), has been found to reduce depressive symptoms in patients with comorbid depression and other diseases.
Jiang Chen   +6 more
doaj   +1 more source

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