Results 51 to 60 of about 571,868 (347)
Glial Cells and Synaptic Plasticity [PDF]
Neural Plasticity, 2016 Neuroglia are composed of highly heterogeneous cellular populations of neural (astrocytes, oligodendrocytes, and NG2 glial cells) and nonneural (microglia) origin that are essential for maintaining efficient neurotransmission, homeostatic cascades, supply of energy metabolites, turnover of neurotransmitters, and establishment of the blood-brain barrier
Fushun Wang +4 more
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SUMOylation of FOXP1 regulates transcriptional repression via CtBP1 to drive dendritic morphogenesis
Scientific Reports, 2017 Forkhead Box P (FOXP) transcriptional repressors play a major role in brain development and their dysfunction leads to human cognitive disorders. However, little is known about how the activity of these proteins is regulated.
Daniel L. Rocca +2 more
doaj +1 more source
Cell Reports, 2017 Summary: Ionotropic glutamate receptor (iGluR) trafficking and function underpin excitatory synaptic transmission and plasticity and shape neuronal networks.
Ashley J. Evans +4 more
doaj +1 more source
Nature Neuroscience, 2019 Microglia are the brain’s resident innate immune cells and also have a role in synaptic plasticity. Microglial processes continuously survey the brain parenchyma, interact with synaptic elements and maintain tissue homeostasis.
Rianne D. Stowell +10 more
semanticscholar +1 more source
Learning with delayed synaptic plasticity [PDF]
Proceedings of the Genetic and Evolutionary Computation Conference, 2019 The plasticity property of biological neural networks allows them to perform learning and optimize their behavior by changing their configuration. Inspired by biology, plasticity can be modeled in artificial neural networks by using Hebbian learning rules, i.e.
Yaman A. +4 more
openaire +5 more sources
Synaptic Plasticity and the Warburg Effect [PDF]
Cell Metabolism, 2014 Functional brain imaging studies show that in certain brain regions glucose utilization exceeds oxygen consumption, indicating the predominance of aerobic glycolysis. In this issue, Goyal et al. (2014) report that this metabolic profile is associated with an enrichment in the expression of genes involved in synaptic plasticity and remodeling processes.
Pierre J. Magistretti +2 more
openaire +4 more sources
Purification tags markedly affect self‐aggregation of CPEB3
FEBS Letters, EarlyView.Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito +6 more
wiley +1 more source
Nature Communications, 2021 In this study, acetylcholine release is shown to reorganise hippocampal CA1 inhibitory networks resulting in prioritisation of entorhinal input over CA3 input. This is achieved by activation of a combination of M3 and M4 muscarinic receptors.
Jon Palacios-Filardo +7 more
doaj +1 more source
BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity
Cellular and molecular neurobiology, 2017 Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed and extensively studied neurotrophins in the mammalian brain. Among its prominent functions, one can mention control of neuronal and glial development, neuroprotection, and ...
P. Kowiański +5 more
semanticscholar +1 more source
ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling
FEBS Letters, EarlyView.In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li +3 more
wiley +1 more source