Results 51 to 60 of about 564,334 (388)
Linking spontaneous and stimulated spine dynamics
Communications Biology, 2023 Our brains continuously acquire and store memories through synaptic plasticity. However, spontaneous synaptic changes can also occur and pose a challenge for maintaining stable memories.
Maximilian F. Eggl +4 more
doaj +1 more source
Nature Neuroscience, 2019 Microglia are the brain’s resident innate immune cells and also have a role in synaptic plasticity. Microglial processes continuously survey the brain parenchyma, interact with synaptic elements and maintain tissue homeostasis.
Rianne D. Stowell +10 more
semanticscholar +1 more source
Synaptic Plasticity and the Warburg Effect [PDF]
Cell Metabolism, 2014 Functional brain imaging studies show that in certain brain regions glucose utilization exceeds oxygen consumption, indicating the predominance of aerobic glycolysis. In this issue, Goyal et al. (2014) report that this metabolic profile is associated with an enrichment in the expression of genes involved in synaptic plasticity and remodeling processes.
Pierre J. Magistretti +2 more
openaire +5 more sources
Strong Allee effect synaptic plasticity rule in an unsupervised learning environment [PDF]
arXiv, 2022 Synaptic plasticity or the ability of a brain to changes one or more of its functions or structures has generated and is sill generating a lot of interest from the scientific community especially neuroscientists. These interests especially went into high gear after empirical evidences were collected that challenged the established paradigm that human ...
arxiv
Endoplasmic reticulum visits highly active spines and prevents runaway potentiation of synapses
Nature Communications, 2020 In hippocampal pyramidal cells, a subset of dendritic spines contain endoplasmic reticulum (ER). Here, the authors show that ER enters dendritic spines in a non-random manner, during high synaptic activity with the function of limiting synaptic strength.
Alberto Perez-Alvarez +5 more
doaj +1 more source
SUMOylation of FOXP1 regulates transcriptional repression via CtBP1 to drive dendritic morphogenesis
Scientific Reports, 2017 Forkhead Box P (FOXP) transcriptional repressors play a major role in brain development and their dysfunction leads to human cognitive disorders. However, little is known about how the activity of these proteins is regulated.
Daniel L. Rocca +2 more
doaj +1 more source
Synaptic plasticity and phosphorylation [PDF]
Pharmacology & Therapeutics, 2006 A number of neuronal functions, including synaptic plasticity, depend on proper regulation of synaptic proteins, many of which can be rapidly regulated by phosphorylation. Neuronal activity controls the function of these synaptic proteins by exquisitely regulating the balance of various protein kinase and protein phosphatase activity.
openaire +3 more sources
Glial Cells and Synaptic Plasticity [PDF]
Neural Plasticity, 2016 Neuroglia are composed of highly heterogeneous cellular populations of neural (astrocytes, oligodendrocytes, and NG2 glial cells) and nonneural (microglia) origin that are essential for maintaining efficient neurotransmission, homeostatic cascades, supply of energy metabolites, turnover of neurotransmitters, and establishment of the blood-brain barrier
Fushun Wang +4 more
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Mean-field theory of a plastic network of integrate-and-fire neurons [PDF]
Phys. Rev. E 81, 011907 (2010), 2009 We consider a noise driven network of integrate-and-fire neurons. The network evolves as result of the activities of the neurons following spike-timing-dependent plasticity rules. We apply a self-consistent mean-field theory to the system to obtain the mean activity level for the system as a function of the mean synaptic weight, which predicts a first ...
arxiv +1 more source
A Mathematical Model of Tripartite Synapse: Astrocyte Induced Synaptic Plasticity [PDF]
, 2011 In this paper we present a biologically detailed mathematical model of tripartite synapses, where astrocytes modulate short-term synaptic plasticity. The model consists of a pre-synaptic bouton, a post-synaptic dendritic spine-head, a synaptic cleft and a peri-synaptic astrocyte controlling Ca2+ dynamics inside the synaptic bouton.
arxiv +1 more source